Manifestações psicopatológicas e cognitivas associadas à infecção pelo vírus SARS-CoV-2 DOI Creative Commons
Rodolfo Furlan Damiano

Published: May 10, 2023

Introduction: Preliminary studies with patients infected the SARS-CoV-2 virus indicate involvement of different organs and systems, including central nervous system (CNS).Changes in CNS include acute chronic manifestations involving clinical expressions psychiatric, neurological or neuropsychiatric nature.In this present thesis, our objective is to characterize psychopathological cognitive alterations after 6-11 months infection.Objectives: a.To describe infection; b.Identify baseline variables that may predict manifestations" c.To investigate association smell taste changes at d.Correlate biological infection, as measured by general blood tests cytokine panel, correlate them 6 11 after.Methods: About 700 adult individuals laboratory-confirmed diagnosis COVID-19 were evaluated.Such had several data markers collected during hospitalization, being subsequently evaluated multidisciplinary, from discharge.At time, materials again collected.This thesis deals primarily a structured psychiatric interview combined symptom assessment scales battery neuropsychological order assess cognition.Results: The results are presented 3 articles.In Article 1, which involves objectives 1 2, we found: diagnoses 'depression', 'generalized anxiety disorder' 'post-traumatic stress observed, respectively, 8%, 15.5% 13 .6% sample.Memory decline was subjectively reported 51.1% patients.Psychiatric outcomes not associated any related severity illness phase, nor psychosocial stressors illness.The article 2 refer 3, is: concomitant moderate/severe olfactory gustatory loss phase significantly worse performance word list memory task.Finally, below 4. multivariate analysis found gender, age, ethnicity, education, comorbidity, frailty physical activity cognition.Bivariate (eg, G-CSF, IFN-alpha2, IL13, IL15, IL1-RA, EL1-alpha, IL45, IL5, IL6, IL7, TNF-Beta, VEGF, C-Reactive Protein D -Dimer) follow-up cognition.However, regression (LASSO), such inflammatory cytokines did remain cognition.Conclusion: Our suggest mental disorders frequent notably depression, generalized post-traumatic disorders.In addition these, about half sample report decline.However, these findings variable disease disease.On other hand, observed chemosensory tasks.Finally, support hypothesis (both

Language: Английский

Fatigue and cognitive impairment after COVID-19: A prospective multicentre study DOI Creative Commons
Tim J. Hartung, Christian Neumann, Thomas Bahmer

et al.

EClinicalMedicine, Journal Year: 2022, Volume and Issue: 53, P. 101651 - 101651

Published: Sept. 17, 2022

Language: Английский

Citations

137
Damage to endothelial barriers and its contribution to long COVID DOI Open Access
Xiaoming Wu, Mengqi Xiang, Haijiao Jing

et al.

Angiogenesis, Journal Year: 2023, Volume and Issue: 27(1), P. 5 - 22

Published: April 27, 2023

Language: Английский

Citations

45
The role of immune activation and antigen persistence in acute and long COVID DOI
Skye Opsteen, Jacob K. Files,

Tim Fram

et al.

Journal of Investigative Medicine, Journal Year: 2023, Volume and Issue: 71(5), P. 545 - 562

Published: March 6, 2023

In late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered the global disease 2019 (COVID-19) pandemic. Although most infections cause a self-limited comparable to other upper viral pathogens, portion of individuals develop illness leading substantial morbidity and mortality. Furthermore, an estimated 10%–20% SARS-CoV-2 are followed by post-acute sequelae COVID-19 (PASC), or long COVID. Long COVID is associated with wide variety clinical manifestations including cardiopulmonary complications, persistent fatigue, neurocognitive dysfunction. Severe hyperactivation increased inflammation, which may be underlying in subset individuals. However, immunologic mechanisms driving development still under investigation. Early pandemic, our group others observed immune dysregulation persisted into convalescence after COVID-19. We subsequently cohort experiencing demonstrated SARS-CoV-2-specific CD4 + CD8 T-cell responses antibody affinity patients symptoms. These data suggest symptoms due chronic activation presence antigen. This review summarizes literature date detailing how these observations relate addition, we discuss recent findings support antigen evidence that this phenomenon contributes local systemic inflammation heterogeneous nature seen

Language: Английский

Citations

41
Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers DOI Creative Commons
Rodolfo Furlan Damiano, Cristiana Castanho de Almeida Rocca, Antônio de Pádua Serafim

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 23, 2023

To analyze the potential impact of sociodemographic, clinical and biological factors on long-term cognitive outcome patients who survived moderate severe forms COVID-19.We assessed 710 adult participants (Mean age = 55 ± 14; 48.3% were female) 6 to 11 months after hospital discharge with a complete battery, as well psychiatric, laboratory evaluation. A large set inferential statistical methods was used predict variables associated any impairment, focus panel 28 cytokines other blood inflammatory disease severity markers.Concerning subjective assessment performance, 36.1% reported slightly poorer overall 14.6% being severely impacted, compared their pre-COVID-19 status. Multivariate analysis found sex, age, ethnicity, education, comorbidity, frailty physical activity general cognition. bivariate that G-CSF, IFN-alfa2, IL13, IL15, IL1.RA, EL1.alfa, IL45, IL5, IL6, IL7, TNF-Beta, VEGF, Follow-up C-Reactive Protein, D-Dimer significantly (p<.05) However, LASSO regression included all follow-up variables, markers did not support these findings.Though we identified several sociodemographic characteristics might protect against impairment following SARS-CoV-2 infection, our data do prominent role for status (both during acute long-stage COVID-19) or background (also explain deficits can follow COVID-19 infection.

Language: Английский

Citations

25
Psychological factors associated with Long COVID: a systematic review and meta-analysis DOI Creative Commons
Petra Engelmann, Max Reinke, Clara Stein

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 74, P. 102756 - 102756

Published: July 27, 2024

Language: Английский

Citations

12
A systematic analysis of the literature on the post-COVID-19 condition in Latin America focusing on epidemiology, clinical characteristics, and risk of bias DOI Creative Commons
Vivienne C. Bachelet, Belén Carroza, Bruno Morgado

et al.

Medwave, Journal Year: 2025, Volume and Issue: 25(01), P. e3014 - e3014

Published: Jan. 16, 2025

This analysis article aimed to identify and analyze all articles published on the post-COVID-19 condition in Latin America Caribbean, focusing epidemiology, clinical characteristics, risk of bias. We did a systematic survey literature with broad inclusion criteria. The only exclusion criteria were referring post-acute COVID-19 sequelae after an intensive care unit stay, which we distinguish from condition. searched MEDLINE/PubMed, LILACS, SciELO, Scopus, Web Science, Epistemonikos. included 55 records, 48 original (44 observational research, 29 had comparison group; four reviews). Various definitions for long COVID reported, or none, few used World Health Organization None studies reported prevalence rates region. extracted signs symptoms our Using Johanna Briggs Institute critical appraisal tools analytic found that most prone limitations biases. conclude more research should be done using rigorous study designs inform public health strategies.

Language: Английский

Citations

1
Cognitive impairment, depressive and anxiety disorders among post-COVID-19 survivors: a follow-up study DOI Creative Commons
Ayesha Aziz,

A.A.M.A.L. Latif,

Sandra W. Elseesy

et al.

Middle East Current Psychiatry, Journal Year: 2025, Volume and Issue: 32(1)

Published: Jan. 22, 2025

Abstract Background Psychiatric signs may be induced by the cytokine storm that is implicated in immune response to coronavirus through neuro-inflammation. Survivors disclosed symptoms of obsessive–compulsive disorder, melancholy, anxiety, panic and post-traumatic stress disorder. For first year following SARS disease, they generally suffer from suicide psychosis. Aim To evaluate presence cognitive impairment, anxiety disorders, depression adult survivors COVID-19, 1 month 3 months post-recovery. Method It an observational longitudinal study. Forty-four COVID-19 survivor patients, with no past psychiatric history were evaluated at after recovery. The Montreal Cognitive Impairment Basic (MoCA-B) was employed impairment. However, depressive disorders identified via structured clinical interview for DSM IV, axis I (SCID-I) their severity examined Beck Depression Inventory (BDI) Anxiety (BAI) consecutively. Results Regarding MoCA-B results showed a mean score 25.95 ± 1.98 1st 27.7 1.05 2nd interview, marked change, P- value = 0.001. SCID-I 43.2% our sample diagnosed both post-recovery, improvement some cases affect only 18.2%, showing statistically significant difference, 0.036. percentage patients who suffered sleep difficulties 59.1% 27.3% interview. While 61.4% fatigue low concentration went down 31.8% P -value < those also declined 2nd, BDI 12.30 10.46, 7.09 9.24 variation 0.001, while BAI means 18.18 16.85 11.32 16.12 difference Conclusion functions; especially delayed recall; one important sequelae, In addition form depressed/anxious mood, fatigue, decreased concentration, disturbances. over period

Language: Английский

Citations

1
Neuropsychiatric post-acute sequelae of COVID-19: prevalence, severity, and impact of vaccination DOI Open Access
Alaa Elmazny, Rehab Magdy, Mona Hussein

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2023, Volume and Issue: 273(6), P. 1349 - 1358

Published: Jan. 27, 2023

Language: Английский

Citations

15
Long COVID: neurological manifestations - an updated narrative review DOI Creative Commons
José Wagner Leonel Tavares-Júnior, Gabriella Cunha Vieira Ciurleo, Alissa Moura Formiga

et al.

Dementia & Neuropsychologia, Journal Year: 2024, Volume and Issue: 18

Published: Jan. 1, 2024

ABSTRACT. Infection with the SARS-CoV-2 virus can lead to neurological symptoms in acute phase and Long COVID phase. These usually involve cognition, sleep, smell disorders, psychiatric manifestations, headache others. This condition is more commonly described young adults women. symptomatology follow severe or mild cases of disease. The importance this issue resides high prevalence phase, which entails significant morbidity population. In addition, such a associated health care costs, some estimates hovering around 3.7 trillion US dollars. review, we will sequentially describe current knowledge about most prevalent COVID, as well their pathophysiology possible biomarkers.

Language: Английский

Citations

5
Real world research on transcranial magnetic stimulation treatment strategies for neuropsychiatric symptoms with long-COVID in Japan DOI Creative Commons
Yoshihiro Noda,

Akiko Sato,

Misaki Shichi

et al.

Asian Journal of Psychiatry, Journal Year: 2022, Volume and Issue: 81, P. 103438 - 103438

Published: Dec. 28, 2022

Language: Английский

Citations

19