Immune-Related LncRNAs as Prognostic Factors for Pediatric Rhabdoid Tumor of the Kidney DOI Creative Commons
Ye Hong, Yi Que, Yang Hu

et al.

Disease Markers, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 11

Published: June 15, 2022

Background. Immune-related long noncoding RNAs (IrlncRNAs) are recognized as important prognostic factors in a variety of cancers, but thus far, their value pediatric rhabdoid tumor the kidney (pRTK) has not been reported. Here, we clarified associations between IrlncRNAs and overall survival (OS) pRTK patients constructed model to predict prognosis. Methods. We accessed RNA sequencing data corresponding clinical from Therapeutically Applicable Research Generate Effective Treatments (TARGET) database. An expression profile immune-related genes (Irgenes) lncRNAs was extracted data. were defined by co-expression analysis Irgenes. The limma R package used identify differential IrlncRNAs. Univariate multivariate Cox regression analyses conducted build model. performance this validated multimethods, like ROC curve analysis. Results. A total 1097 defined. identified 7 (AC004791.2, AP003068.23, RP11-54O7.14, RP11-680F8.1, TBC1D3P1-DHX40P1, TUNAR, XXbac-BPG308K3.5) significantly associated with OS. Multivariate best based on AC004791.2, TUNAR. According model, risk score each patient calculated, divided into high-risk low-risk groups accordingly. time better than ( p < 0.001 ). (hazard ratio 1.098, 95% confidence interval 1.048–1.149, p <0.001) 1.095, 1.043–1.150, p confirmed that reliable independent prediction Time-dependent showed 1-year AUC stage, age, sex 0.824, 0.673, 0.531, 0.495, respectively, which suggested predictor patients. Conclusions. 5 robust could other factors. Additionally, mechanism regulation action prognosis-associated provide new avenues for basic research explore initiation development order prevent treat pRTK.

Language: Английский

Nanomaterial-based Electrochemical Biosensors DOI
Kübra Gençdağ Şensoy, Fatma Akpınar, Mihrican Muti

et al.

Current Nanoscience, Journal Year: 2022, Volume and Issue: 20(1), P. 18 - 30

Published: Aug. 20, 2022

Abstract: Nanomaterials often show very different sizes, shapes, and stability properties. They also facilitate electron transfer can be easily modified with chemical ligands biomolecules. These properties, combined the ease of miniaturizing nanoscales their application to sensing devices, make nanomaterials well suited for essential chemical/biochemical applications. : are superior materials not only due structural properties but functional Using various methods makes it possible change available stack Nano-sized preferred in modern technological systems because they have a large surface area optical electronic In this study, electrochemical biosensor applications based on sensors were evaluated terms analytical parameters, such as detection limit, linear range, features, easy fabrication, storage stability, reproducibility. Besides, advantages using examined under 6 headings enzyme biosensors, immunosensors, nucleic acid sensors, cell, phage, aptasensors.

Language: Английский

Citations

697
Nanozyme‐Enhanced Electrochemical Biosensors: Mechanisms and Applications DOI
Zhongwei Yang, Jiawei Guo, Longwei Wang

et al.

Small, Journal Year: 2023, Volume and Issue: 20(14)

Published: Nov. 20, 2023

Abstract Nanozymes, as innovative materials, have demonstrated remarkable potential in the field of electrochemical biosensors. This article provides an overview mechanisms and extensive practical applications nanozymes First, definition characteristics are introduced, emphasizing their significant role constructing efficient sensors. Subsequently, several common categories nanozyme materials delved into, including metal‐based, carbon‐based, metal‐organic framework, layered double hydroxide nanostructures, discussing Regarding mechanisms, two key roles particularly focused biosensors: selective enhancement signal amplification, which crucially support sensor performance. In terms applications, widespread use nanozyme‐based biosensors showcased various domains. From detecting biomolecules, pollutants, nucleic acids, proteins, to cells, providing robust means for high‐sensitivity detection. Furthermore, insights into future development is provided, encompassing improvements optimizations design integration, expansion application fields through interdisciplinary collaboration. conclusion, this systematically presents biosensors, offering valuable references prospects research field.

Language: Английский

Citations

63
Optical diagnostic imaging and therapy for thyroid cancer DOI Creative Commons

Chengying Shao,

Zhenfang Li,

Chengchi Zhang

et al.

Materials Today Bio, Journal Year: 2022, Volume and Issue: 17, P. 100441 - 100441

Published: Sept. 26, 2022

Thyroid cancer, as one of the most common endocrine cancers, has seen a surge in incidence recent years. This is likely due to lack specificity and accuracy its traditional diagnostic modalities, leading overdiagnosis thyroid nodules. Although there are several treatment options available, they limited surgery

Language: Английский

Citations

41
Biomedical applications of aptamer-modified chitosan nanomaterials: An updated review DOI Creative Commons
Sonia Fathi‐karkan, Shekoufeh Mirinejad, Fulden Ulucan‐Karnak

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 238, P. 124103 - 124103

Published: March 21, 2023

Among polysaccharides of environmental and economic interest, chitosan (CS) is receiving much attention, particularly in the food biotechnology industries to encapsulate active ingredients immobilize enzymes. CS nanoparticles (CS NPs) combine intrinsic beneficial properties both natural polymers nanoscale particles such as quantum size effect, biocompatibility, biodegradability, ease modification, possessing enhanced capacity for bioimaging, drug delivery, biosensing applications. Aptamers are single-stranded oligonucleotides that can fold into predetermined structures bind corresponding biomolecules. They mainly used targeting ligands biosensors, disease diagnostic kits, treatment strategies. deliver contrast agents drugs cancer cells tissues, control microorganism growth, also precisely target pathogens. Aptamer-conjugated NPs significantly improve efficacy conventional therapies, minimize their side effects on normal overcome permeability retention (EPR) effect. Further, aptamer-conjugated carbohydrate-based nanobiopolymers have shown excellent antibacterial antiviral be develop novel biosensors efficient detection antibiotics, toxins, other This updated review aims provide a comprehensive overview bioapplications innovative therapeutic platforms, limitations, potential future directions.

Language: Английский

Citations

32
Nanotherapeutic approaches for delivery of long non-coding RNAs: an updated review with emphasis on cancer DOI
Fatemeh Davodabadi, Shekoufeh Mirinejad, Sumira Malik

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(8), P. 3881 - 3914

Published: Jan. 1, 2024

The long noncoding RNAs (lncRNAs) comprise a wide range of RNA species whose length exceeds 200 nucleotides, which regulate the expression genes and cellular functions in organisms.

Language: Английский

Citations

11
Nanobiosensors for detection of opioids: A review of latest advancements DOI Creative Commons
Mahtab Razlansari, Fulden Ulucan‐Karnak,

Masoud Kahrizi

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2022, Volume and Issue: 179, P. 79 - 94

Published: Sept. 5, 2022

Opioids are generally used as analgesics in pain treatment. Like many drugs, they have side effects when overdosed and can cause addiction problems. Illegal drug use misuse becoming a major concern for authorities worldwide; thus, it is critical to precise procedures detecting them confiscated samples, biological fluids, wastewaters. Routine blood urine tests insufficient highly selective determinations cross-reactivities. For this purpose, nanomaterial-based biosensors great tools determine opioid intakes, continuously monitoring the drugs with high sensitivity selectivity even at very low sample volumes. Nanobiosensors comprise signal transducer nanostructure which recognition molecule immobilized onto its surface. Lately, nanobiosensors been extensively utilized molecular detection of opioids. The usage novel nanomaterials biosensing has impressed researchers who work on developing biosensors. Nanomaterials large surface area develop shorter reaction times higher than conventional Colorimetric fluorescence sensing methods two kinds optical sensor systems based nanomaterials. Noble metal nanoparticles (NPs), such silver gold, most frequently applied colorimetric techniques, owing their unique feature plasmon resonance. Despite progress an extensive spectrum over last decades, future purpose low-cost, high-throughput, multiplexed clinical diagnostic Lab-on-a-Chip instruments yet be fulfilled. In review, concise overview opioids (such tramadol buprenorphine, oxycodone fentanyl, methadone morphine) provided well information classification, mechanism action, routine tests, new technologies various NPs. order highlight trend development biosensor applications opioids, recent literature examples nanomaterial type, target molecules, limits discussed.

Language: Английский

Citations

35
Towards Development of Molecularly Imprinted Electrochemical Sensors for Food and Drug Safety: Progress and Trends DOI Creative Commons

Shuhong Zhou,

Chen Liu,

Lin Jianguo

et al.

Biosensors, Journal Year: 2022, Volume and Issue: 12(6), P. 369 - 369

Published: May 27, 2022

Due to their advantages of good flexibility, low cost, simple operations, and small equipment size, electrochemical sensors have been commonly employed in food safety. However, when they are applied detect various or drug samples, stability specificity can be greatly influenced by the complex matrix. By combining with molecular imprinting techniques (MIT), will endowed new functions specific recognition separation, which make them powerful tools analytical fields. MIT-based (MIECs) require preparing modifying molecularly imprinted polymers (MIPs) on electrode surface. In this review, we explored different MIECs regarding design, working principle functions. Additionally, applications safety were discussed, as well challenges prospects for developing methods. The strengths weaknesses including fouling discussed indicate research direction future sensors.

Language: Английский

Citations

30
Recent advances on high-efficiency of microRNAs in different types of lung cancer: a comprehensive review DOI Creative Commons

Mohammad Saleh Sadeghi,

Mohadeseh lotfi,

Narges Soltani

et al.

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 20, 2023

Abstract Carcinoma of the lung is among most common types cancer globally. Concerning its histology, it categorized as a non-small cell carcinoma (NSCLC) and small (SCLC) subtype. MicroRNAs (miRNAs) are member non-coding RNA whose nucleotides range from 19 to 25. They known be critical regulators via epigenetic control oncogenes expression by regulating tumor suppressor genes. miRNAs have an essential function in tumorous microenvironment modulating growth, metastasis, angiogenesis, metabolism, apoptosis. Moreover, wide information produced several investigations indicates their tumor-suppressing, oncogenic, diagnostic assessment, predictive marker functions different malignancy. miRNA mimics or anti-miRNAs can transferred into cell, with possible curative implications. As result, hold promise targets for treatment detection. In this study, we investigate various malignancy, which been achieved recent years that show cancer-associated regulation expression, concerning beginning, development, resistance chemotherapy, also probability utilize biomarkers therapy reaction. Graphical abstract

Language: Английский

Citations

22
One-step self-assembly of quantum dot-based spherical nucleic acid nanostructure for accurate monitoring of long noncoding RNA MALAT1 in living cells and tissues DOI
Qian Zhang, Ran Zhao, Yan Zhang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 469, P. 144021 - 144021

Published: June 9, 2023

Language: Английский

Citations

14
Recent Advances in Nanotechnology for the Management of Klebsiella pneumoniae–Related Infections DOI Creative Commons
Mahmood Barani, Hadis Fathizadeh, Hassan Arkaban

et al.

Biosensors, Journal Year: 2022, Volume and Issue: 12(12), P. 1155 - 1155

Published: Dec. 10, 2022

Klebsiella pneumoniae is an important human pathogen that causes diseases such as urinary tract infections, pneumonia, bloodstream bacteremia, and sepsis. The rise of multidrug-resistant strains has severely limited the available treatments for K. infections. On other hand, activity (and related infections) urgently requires improved management strategies. A growing number medical applications are using nanotechnology, which uses materials with atomic or molecular dimensions, to diagnose, eliminate, reduce different In this review, we start traditional treatment detection method then concentrate on selected studies (2015–2022) investigated application nanoparticles separately in combination techniques against pneumoniae.

Language: Английский

Citations

18