Drug Resistance Updates,
Journal Year:
2024,
Volume and Issue:
77, P. 101140 - 101140
Published: Aug. 16, 2024
Membrane
protein-mediated
resistance
is
a
multidisciplinary
challenge
that
spans
fields
such
as
medicine,
agriculture,
and
environmental
science.
Understanding
its
complexity
devising
innovative
strategies
are
crucial
for
treating
diseases
like
cancer
managing
resistant
pests
in
agriculture.
This
paper
explores
the
dual
nature
of
mechanisms
across
different
organisms:
On
one
hand,
animals,
bacteria,
fungi,
plants,
insects
exhibit
convergent
evolution,
leading
to
development
similar
mechanisms.
other
influenced
by
diverse
pressures
structural
differences
among
organisms,
they
also
demonstrate
divergent
characteristics.
prevalent
insects,
reflecting
their
shared
survival
evolved
through
evolution
address
challenges.
However,
variations
ecological
environments
biological
characteristics
result
differing
responses
resistance.
Therefore,
examining
these
not
only
enhances
our
understanding
adaptive
but
provides
theoretical
support
insights
addressing
drug
advancing
pharmaceutical
development.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Feb. 21, 2024
The
fall
armyworm
(FAW)
Spodoptera
frugiperda
is
a
severe
economic
pest
of
multiple
crops
globally.
Control
this
often
achieved
using
insecticides;
however,
over
time,
S.
has
developed
resistance
to
new
mode
action
compounds,
including
diamides.
Previous
studies
have
indicated
diamide
complex
developmental
process
involving
detoxification
genes.
Still,
the
mechanism
underlying
possible
involvement
microRNAs
in
post-transcriptional
regulation
not
yet
been
elucidated.
In
study,
global
screen
(miRNAs)
revealed
109
known
and
63
novel
miRNAs.
Nine
miRNAs
(four
five
novel)
were
differentially
expressed
between
insecticide-resistant
-susceptible
strains.
Gene
Ontology
analysis
predicted
putative
target
transcripts
encoding
significant
genes
belonging
pathways.
Additionally,
are
involved
response
exposure,
indicating
they
probably
associated
with
pathway.
Thus,
study
provides
comprehensive
evidence
for
link
repressed
miRNA
expression
induced
that
possibly
mediate
through
regulation.
These
findings
highlight
important
clues
further
research
unravel
roles
mechanisms
conferring
resistance.
Frontiers in Genetics,
Journal Year:
2024,
Volume and Issue:
15
Published: July 5, 2024
Pest
control
heavily
relies
on
chemical
pesticides
has
been
going
for
decades.
However,
the
indiscriminate
use
of
often
results
in
development
resistance
pests.
Almost
all
pests
have
developed
some
degree
to
pesticides.
Research
showed
that
mechanisms
insecticide
insects
encompass
metabolic
resistance,
behavioral
penetration
and
target-site
resistance.
these
mainly
focused
