Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(6)
Published: Nov. 9, 2023
Bisphenol
A
(BPA)
is
a
prevalent
endocrine
disruptor
found
in
natural
environments.
Exposure
to
BPA
has
been
associated
with
male
infertility.
The
phytochemical
icariin
(ICA)
demonstrated
significant
promise
for
the
treatment
of
However,
its
effectiveness
limited
due
low
bioavailability,
poor
water
solubility,
and
insufficient
targeting
abilities.
Herein,
novel
nanoparticles
are
generated
from
silk
fibroin,
which
used
load
ICA.
efficient
drug
delivery
system
(ICA-SNPs)
result
significantly
focused
distribution
spermatogonium,
enhancing
anti-infertility
properties
ICA,
can
effectively
mitigate
spermatogenesis
dysfunction
induced
by
BPA,
control
serum
sex
hormone
levels,
enhance
testicular
ultrastructure.
Additionally,
ICA-SNPs
restore
primarily
via
biosynthesis,
spermatogonium
meiosis
process,
glycerophospholipid
metabolism.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(26)
Published: June 28, 2024
Oral
medication
for
ulcerative
colitis
(UC)
is
often
hindered
by
challenges
such
as
inadequate
accumulation,
limited
penetration
of
mucus
barriers,
and
the
intricate
task
mitigating
excessive
ROS
inflammatory
cytokines.
Here,
we
present
a
strategy
involving
sodium
alginate
microspheres
(SAMs)
incorporating
M2
macrophage
membrane
(M2M)-coated
Janus
nanomotors
(denominated
Motor@M2M)
targeted
treatment
UC.
SAM
provides
protective
barrier,
ensuring
that
Motor@M2M
withstands
harsh
gastric
milieu
exhibits
controlled
release.
M2M
enhances
targeting
precision
to
tissues
acts
decoy
neutralization
Catalytic
decomposition
H
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 18, 2024
Abstract
Background
The
complex
etiology
and
pathogenesis
underlying
Chronic
Non-Bacterial
Prostatitis
(CNP),
coupled
with
the
existence
of
a
Blood
Prostate
Barrier
(BPB),
contribute
to
lack
specificity
poor
penetration
most
drugs.
Emodin
(EMO),
potential
natural
compound
for
CNP
treatment,
exhibits
commendable
anti-inflammatory,
anti-oxidant,
anti-fibrosis
properties
but
suffers
from
same
problems
as
other
Methods
By
exploiting
recognition
lactoferrin
(LF)
receptors
that
target
intestinal
epithelial
cells
(NCM-460)
prostate
(RWPE-1),
pathway
is
established
transrectal
absorption
EMO
effectively
reach
prostate.
Additionally,
hyaluronic
acid
(HA)
employed,
recognizing
CD44
which
macrophages
within
inflamed
This
interaction
facilitates
intraprostatic
delivery
EMO,
leading
its
pronounced
anti-inflammatory
effects.
A
thermosensitive
hydrogel
(CS-Gel)
prepared
chitosan
(CS)
β-glycerophosphate
disodium
salt
(β-GP)
was
used
rectal
drug
strong
adhesion
achieve
effective
retention
sustained
slow
release.
Thus,
we
developed
triple-targeted
nanoparticle
(NPs)/thermosensitive
(Gel)
system.
In
this
process,
LF,
positive
charge,
utilized
load
through
dialysis,
producing
LF@EMO-NPs.
Subsequently,
HA
employed
encapsulate
EMO-loaded
LF
nanoparticles
via
electrostatic
adsorption,
yielding
HA/LF@EMO-NPs.
Finally,
HA/LF@EMO-NPs
lyophilized
powder
added
CS-Gel
(HA/LF@EMO-NPs
Gel).
Results
Cellular
assays
indicated
NCM-460
RWPE-1
showed
high
uptake
both
LF@EMO-NPs
HA/LF@EMO-NPs,
while
Raw
264.7
exhibited
substantial
For
LPS-induced
cells,
can
reduce
inflammatory
responses
by
modulating
TLR4/NF-κB
signaling
pathways.
Tissue
imaging
corroborated
capacity
HA/LF-modified
formulations
breach
BPB,
accumulating
gland's
lumen.
Animal
experiments
administration
Gel
significantly
reduced
cytokine
expression,
oxidative
stress
levels
fibrosis
in
rats,
addition
exerting
effects
inhibiting
NF-κB
without
obvious
toxicity.
Conclusion
NPs/Gel
system
slow-release
shows
great
treatment
CNP.
Graphical
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
164, P. 114967 - 114967
Published: June 6, 2023
Lactoferrin
(LF)
is
a
protein
found
in
several
bodily
fluids,
such
as
milk.
This
has
diverse
range
of
functions
and
evolutionarily
conserved.
multifunction
with
distinct
biological
abilities
affecting
mammals'
immune
structures.
Reports
indicated
that
the
daily
uptake
LF
from
dairy
products
unsatisfactory
detecting
further
health-promoting
abilities.
Research
shown
it
protects
against
infection,
mitigates
cellular
senescence,
improves
nutritional
quality.
Additionally,
being
studied
potential
treatment
for
various
diseases
conditions,
including
gastrointestinal
issues
infections.
Studies
have
also
demonstrated
its
effectiveness
viruses
bacteria.
In
this
article,
we'll
look
closer
at
structure
activities,
antimicrobial,
anti-viral,
anti-cancer,
anti-osteoporotic,
detoxifying,
immunomodulatory
properties.
More
specifically,
protective
effect
oxidative
DNA
damage
was
clarified
through
ability
to
abolish
damaging
without
interfacing
host
genetic
material.
Fortification
mitochondria
dysfunction
syndromes
via
sustaining
redox
status
biogenesis
suppressing
apoptosis
autophagy
singling.
examine
benefits
lactoferrin
provide
an
overview
recent
clinical
trials
conducted
use
laboratory
living
models.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 26, 2024
The
oral
administration
of
drugs
for
treating
ulcerative
colitis
(UC)
is
hindered
by
several
factors,
including
inadequate
gastrointestinal
stability,
insufficient
accumulation
in
colonic
lesions,
and
uncontrolled
drug
release.
