Micro and nano-carriers-based pulmonary drug delivery system: Their current updates, challenges, and limitations – A review

JCIS Open, Journal Year: 2023, Volume and Issue: 12, P. 100095 - 100095

Published: Sept. 29, 2023

The lung is an attractive target for drug delivery because of the ease non-invasive administration via inhalation, bypassing metabolism in liver, direct to respiratory system treatment diseases, and a large surface area absorption. Nanocarrier systems offer several benefits pulmonary delivery, including uniform distribution among alveoli, improved solubility, sustained release, which reduces dosing frequency enhances patient compliance, potential cell internalization. Nanomedicine also being utilized combat emerging infectious illnesses like SARS-CoV, SARS-CoV-2, MERS-CoV, influenza A/H1N1. This review gives quick rundown diseases caused by agents such as bacterial, viral, biological roadblocks that prevent effective recalcitrant tract infections. We emphasized summarized recent efforts these infections using novel inhaled formulation-mediated strategies nanocarriers liposomes, polymeric nanoparticles, SLNs. In addition, we reviewed latest findings advancements regarding development inhalable formulations circumvent barriers boost bioavailability.

Language: Английский

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Current Understanding of Polyphenols to Enhance Bioavailability for Better Therapies

Biomedicines, Journal Year: 2023, Volume and Issue: 11(7), P. 2078 - 2078

Published: July 24, 2023

In recent years, plant polyphenols have become a popular focus for the development of novel functional foods. Polyphenols, class bioactive compounds, including flavonoids, phenolic acids, and lignans, are commonly found in plant-based diets with variety biological actions, antioxidant, anti-inflammatory, anticancer effects. Unfortunately, not widely used nutraceuticals since many chemicals possess poor oral bioavailability. Thankfully, can be encapsulated transported using bio-based nanocarriers, thereby increasing their Polyphenols' limited water solubility low bioavailability limiting factors practical usage, but this issue resolved if suitable delivery vehicles developed encapsulating delivering polyphenolic compounds. This paper provides an overview study nanocarriers enhancement polyphenol bioavailability, as well summary health advantages prevention treatment several diseases.

Language: Английский

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High internal phase emulsions stabilized by pea protein isolate modified by ultrasound and pH-shifting: Effect of chitosan self-assembled particles

Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 141, P. 108715 - 108715

Published: March 23, 2023

Language: Английский

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Advances in chitosan and chitosan derivatives for biomedical applications in tissue engineering: An updated review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129999 - 129999

Published: Feb. 7, 2024

Language: Английский

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Degradable chitosan-based bioplastic packaging: Design, preparation and applications

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131253 - 131253

Published: March 30, 2024

Language: Английский

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Enhanced barrier and antioxidant properties of gelatin films by structural-colored bioactive materials for food packaging

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 150, P. 109744 - 109744

Published: Jan. 8, 2024

Language: Английский

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Recent Advances of Chitosan-Based Hydrogels for Skin-Wound Dressings

Gels, Journal Year: 2024, Volume and Issue: 10(3), P. 175 - 175

Published: Feb. 29, 2024

The management of wound healing represents a significant clinical challenge due to the complicated processes involved. Chitosan has remarkable properties that effectively prevent certain microorganisms from entering body and positively influence both red blood cell aggregation platelet adhesion in bloodstream, resulting favorable hemostatic outcome. In recent years, chitosan-based hydrogels have been widely used as dressings their biodegradability, biocompatibility, safety, non-toxicity, bioadhesiveness, soft texture resembling extracellular matrix. This article first summarizes an overview main chemical modifications chitosan for then reviews desired hydrogel dressings. applications healing, including burn wounds, surgical infected diabetic wounds are discussed. Finally, future prospects It is anticipated this review will form basis development range treatment.

Language: Английский

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Preparation and characterization of zein-tannic acid nanoparticles/chitosan composite films and application in the preservation of sugar oranges

Food Chemistry, Journal Year: 2023, Volume and Issue: 437, P. 137673 - 137673

Published: Oct. 4, 2023

Language: Английский

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Chitosan Hydrogels for Water Purification Applications

Gels, Journal Year: 2023, Volume and Issue: 9(8), P. 664 - 664

Published: Aug. 17, 2023

Chitosan-based hydrogels have gained significant attention for their potential applications in water treatment and purification due to remarkable properties such as bioavailability, biocompatibility, biodegradability, environmental friendliness, high pollutants adsorption capacity, capacity. This article comprehensively reviews recent advances chitosan-based hydrogel materials applications. The synthesis methods, structural properties, performance of are critically analyzed. incorporation various nanomaterials into hydrogels, nanoparticles, graphene, metal-organic frameworks, has been explored enhance performance. mechanisms purification, including adsorption, filtration, antimicrobial activity, also discussed detail. the removal pollutants, heavy metals, organic contaminants, microorganisms, from sources is highlighted. Moreover, challenges future perspectives illustrated. Overall, this provides valuable insights current state art regarding highlights addressing global pollution challenges.

Language: Английский

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Advances in preparation, biomedical, and pharmaceutical applications of chitosan-based gold, silver, and magnetic nanoparticles: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 251, P. 126390 - 126390

Published: Aug. 16, 2023

Language: Английский

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