Cancer Nanotechnology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: June 24, 2024
Abstract
Lung
cancer
has
been
mentioned
as
the
first
and
second
most
prevalent
among
males
females
worldwide,
respectively
since
conventional
approaches
do
not
have
enough
efficiency
in
its
suppression.
Therefore,
a
biocompatible
efficient
polylactic-co-glycolic
acid
(PLGA:
P)-
poly-ε-caprolactone
(PCL:
P)
copolymer
was
fabricated
for
delivery
of
relatively
insoluble
curcumin
(Cur)
to
A549
lung
cells.
Next,
physicochemical
aspects
synthesized
nanobeads
were
characterized
by
applying
analytical
sets,
including
FT-IR,
DLS,
TEM,
TGA
nano-metric
size
(20–45
nm)
1.29%
Cur
entrapment
determined
P-P-Cur
nano-beads.
Thereafter,
controlled
(5%
within
2
h
at
pH
7.4)
pH-sensitive
(nearly
50%
4
5.0)
drug
release
manner
observed
nanobeads.
biomedical
assays
conducted
suppression
ability
41%
cell
viability
after
24
treatment
with
200
nM
concentration
7.55%
cycle
arrest
5
post-treatment
100
(IC
50
)
attained
P-P-Cur.
Also,
7-fold
increase
2-fold
decrease
expressions
Caspase-9
(apoptotic
gene)
Bcl2
(anti-apoptotic
which
further
approved
inhibition
potency
sample.
The
cellular
uptake
results
indicated
91%
internalization
cells
while
it
less
than
1%
pure
Cur.
These
data
demonstrated
that
can
use
system
cancer.
Discover Nano,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: Oct. 10, 2023
Abstract
The
significance
of
green
synthesized
nanomaterials
with
a
uniform
shape,
reduced
sizes,
superior
mechanical
capabilities,
phase
microstructure,
magnetic
behavior,
and
performance
cannot
be
overemphasized.
Iron
oxide
nanoparticles
(IONPs)
are
found
within
the
size
range
1–100
nm
in
have
diverse
applications
fields
such
as
biomedicine,
wastewater
purification,
environmental
remediation.
Nevertheless,
understanding
their
fundamental
material
composition,
chemical
reactions,
toxicological
properties,
research
methodologies
is
constrained
extensively
elucidated
during
practical
implementation.
importance
producing
IONPs
using
advanced
nanofabrication
techniques
that
exhibit
strong
potential
for
disease
therapy,
microbial
pathogen
control,
elimination
cancer
cells
underscored
by
adoption
synthesis
approach.
These
can
serve
viable
alternatives
soil
remediation
contaminants.
Therefore,
this
paper
presents
comprehensive
analysis
conducted
on
different
types
IONP
composite-based
materials.
It
examines
methods
characterization
employed
these
studies
also
addresses
obstacles
encountered
prior
investigations
comparable
objectives.
A
engineering
strategy
was
proposed
synthesis,
characterization,
application
composites
impact.
Additionally,
influence
structure,
biocompatibility,
toxicity,
milling
time,
nanoparticle
size,
shape
discussed.
study
proposes
use
biological
physicochemical
more
alternative
mitigate
limitations
imposed
conventional
synthesis.
Carbohydrate Polymer Technologies and Applications,
Journal Year:
2024,
Volume and Issue:
7, P. 100442 - 100442
Published: Jan. 20, 2024
Therapeutic
tools
in
the
biomedical
field
are
increasingly
utilizing
nanoparticles
(NPs)
with
a
small
size
and
large
surface
area.
Chitosan
(CS),
biotic
polymeric
carbohydrate
found
shellfish,
is
promising
carrier
for
these
diagnostic
systems
due
to
its
biocompatibility,
low
toxic
effects,
diverse
shapes.
CS-NPs
therapeutic
transporters
properties
such
as
bionomical,
pH,
heat
sensitivity,
increased
homogeneity,
potential
pass
through
brain.
These
nanomaterials
can
detect
cure
pathological
conditions
using
curative
instruments.
slow
down
movement
growth
of
anti-inflammatory
colonies
while
encouraging
cells
causing
inflammation.
They
could
provide
active
substances
treating
various
medical
conditions,
auto-immune
deformities,
hyperglycemia,
hypersensitivity,
cancer.
Scientific
resources
dedicated
improving
efficacy
CS-NP
agent
compositions.
Recent
discoveries
highlight
medicinal
implications
preparations
drug
delivery
managing
severe
inflammatory
aberrations.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(5), P. 645 - 645
Published: May 10, 2024
In
recent
years,
nanotechnology
has
achieved
a
remarkable
status
in
shaping
the
future
of
biological
applications,
especially
combating
fungal
diseases.
Owing
to
excellence
nanotechnology,
iron
nanoparticles
(Fe
NPs)
have
gained
enormous
attention
years.
this
review,
we
provided
comprehensive
overview
Fe
NPs
covering
key
synthesis
approaches
and
underlying
working
principles,
factors
that
influence
their
properties,
essential
characterization
techniques,
optimization
antifungal
potential.
addition,
diverse
kinds
NP
delivery
platforms
command
highly
effective
release,
with
fewer
toxic
effects
on
patients,
are
great
significance
medical
field.
The
issues
biocompatibility,
toxicity
profiles,
applications
optimized
field
biomedicine
also
been
described
because
these
most
significant
determining
inclusion
clinical
use.
Besides
this,
difficulties
regulations
exist
transition
from
laboratory
experimental
studies
(toxicity,
specific
standards,
safety
concerns)
NPs-based
agents
summarized.
Artificial Cells Nanomedicine and Biotechnology,
Journal Year:
2024,
Volume and Issue:
52(1), P. 564 - 586
Published: Dec. 5, 2024
Cancer
has
a
high
rate
of
incidence
and
mortality
throughout
the
world.
Although
several
conventional
approaches
have
been
developed
for
treatment
cancer,
such
as
surgery,
chemotherapy,
radiotherapy
thermal
therapy,
they
remarkable
disadvantages
which
result
in
inefficient
cancer.
For
example,
immunogenicity,
prolonged
treatment,
non-specificity,
metastasis
cost
are
considered
major
drawbacks
chemotherapy.
Therefore,
there
is
fundamental
requirement
development
breakthrough
technologies
cancer
suppression.
Polysaccharide-based
drug
delivery
systems
(DDSs)
most
reliable
carriers
therapy.
Polysaccharides,
kind
practical
biomaterials,
divided
into
types,
including
chitosan,
alginates,
dextran,
hyaluronic
acid,
cyclodextrin,
pectin,
etc.
Polysaccharides
extracted
from
different
natural
resources
(like
herbal,
marine,
microorganisms,
etc.).
The
potential
features
polysaccharides
made
them
candidates
therapeutics
to
sites;
simple
purification,
ease
modification
functionalization,
hydrophilicity,
serum
stability,
appropriate
loading
capacity,
biocompatibility,
bioavailability,
biodegradability
stimuli-responsive
sustained
release
manner
considerable
aspects
these
biopolymers.
This
review
highlights
applications
polysaccharides-based
DDSs
pharmaceutical
science
