Chitosan–fucoidan encapsulating cinnamaldehyde composite coating films: Preparation, pH-responsive release, antibacterial activity and preservation for litchi

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 333, P. 121968 - 121968

Published: Feb. 20, 2024

Language: Английский

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Chitosan alchemy: transforming tissue engineering and wound healing

RSC Advances, Journal Year: 2024, Volume and Issue: 14(27), P. 19219 - 19256

Published: Jan. 1, 2024

Chitosan, a biopolymer acquired from chitin, has emerged as versatile and favorable material in the domain of tissue engineering wound healing.

Language: Английский

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Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study

ACS Omega, Journal Year: 2025, Volume and Issue: 10(1), P. 1207 - 1225

Published: Jan. 3, 2025

Manufacturing bioactive materials for drug delivery involves developing that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is optimize therapeutic efficacy reduce side effects by combining knowledge from engineering, biology, pharmacology. This study presents detailed bibliometric analysis, exploring the keywords "manufacturing," "bioactive materials," "drug delivery" identify highlight significant advancements field. From Web of Science, 36,504 articles were analyzed, 171 selected deeper identifying key journals, countries, institutions, authors. results field's interdisciplinary nature, grouped into four main themes, including regenerative medicine, scaffolds, three-dimensional (3D) printing, glass, tissue engineering. Future research this area will focus on more effective precise systems using technologies like 3D printing nanotechnology enhance customization control release, aiming efficient therapies.

Language: Английский

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Cryogel Scaffolds for Tissue-Engineering: Advances and Challenges for Effective Bone and Cartilage Regeneration

Gels, Journal Year: 2023, Volume and Issue: 9(12), P. 979 - 979

Published: Dec. 14, 2023

Critical-sized bone defects and articular cartilage injuries resulting from trauma, osteonecrosis, or age-related degeneration can be often non-healed by physiological repairing mechanisms, thus representing a relevant clinical issue due to high epidemiological incidence rate. Novel tissue-engineering approaches have been proposed as an alternative common practices. This cutting-edge technology is based on the combination of three fundamental components, generally referred triad: autologous allogenic cells, growth-stimulating factors, scaffold. Three-dimensional polymer networks are frequently used scaffolds allow cell proliferation tissue regeneration. In particular, cryogels give promising results for this purpose, thanks their peculiar properties. Cryogels indeed characterized interconnected porous structure typical sponge-like behavior, which facilitate cellular infiltration ingrowth. Their composition fabrication procedure appropriately tuned obtain that match requirements specific organ regenerated. These features make interesting regeneration different tissues, including those very complex mechanical physical properties, such bones joints. review, state-of-the-art employment supporting effective osteogenic chondrogenic differentiation functional tissues reported. Current progress challenges implementation in practice also highlighted.

Language: Английский

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Fucoidan-functionalized gelatin methacryloyl microspheres ameliorate intervertebral disc degeneration by restoring redox and matrix homeostasis of nucleus pulposus

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 250, P. 126166 - 126166

Published: Aug. 6, 2023

Language: Английский

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Designing polysaccharide materials for tissue repair and regeneration

APL Materials, Journal Year: 2024, Volume and Issue: 12(8)

Published: Aug. 1, 2024

Tissue repair and regeneration are critical processes for maintaining the integrity function of various organs tissues. Recently, polysaccharide materials protein have garnered interest use in tissue strategies. However, polysaccharides more stable unaffected by temperature pH changes compared to proteins, some can provide stronger mechanical support, which is particularly important constructing tissue-engineered scaffolds wound dressings. This Review provides an in-depth overview origins polysaccharides, advantages materials, processing design In addition, potential restoration tissues such as skin, heart, nerves highlighted. Finally, we discuss depth challenges that still face repair, stability material, regulating characteristics deterioration rates under different conditions. To achieve effective regeneration, future research must focus on further improving functionalities materials.

Language: Английский

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Biomimetic injectable and bilayered hydrogel scaffold based on collagen and chondroitin sulfate for the repair of osteochondral defects

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 257, P. 128593 - 128593

Published: Dec. 4, 2023

Language: Английский

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Polysaccharide-protein based scaffolds for cartilage repair and regeneration

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133495 - 133495

Published: June 27, 2024

Language: Английский

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Interpenetrating Polymer Network of Hydroxyethyl Methacrylate and Chitosan as Cryogels for Tissue Engineering Applications

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(1)

Published: Jan. 1, 2025

ABSTRACT Tissue engineering is a vast expanding field with applications in areas such as tissue/organ transplantation, drug delivery, vitro models, and so on. Biomaterials form an essential component tissue by acting template for cellular activity, therefore, novel tissue‐engineered biomaterials innovative properties are high demand. Hence, this work proposes interpenetrating polymer network cryogel of chitosan hydroxyethyl methacrylate (HEMA) biomaterial uniform cell seeding throughout the matrix. The physical analysis cryogels demonstrated highly macroporous structure exhibiting pore size distribution overall porosity through emission‐scanning electron microscopy (FE‐SEM) sizes lying range 50–200 μm 150–400 horizontal transverse plane, respectively. were also found to be degradable average percent degradation 17.28 ± 1.47% 4 weeks, their mechanical revealed compressive strength 0.05 MPa elastic modulus 3 MPa. Further, biological characterization direct contact test depicted excellent biocompatibility L929 mouse fibroblast MC3T3‐E1 preosteoblasts negligible presence dead cells around cryogel. Uniform increasing proliferation trend was observed on these live‐dead staining MTT assay at day 1, 3, 7‐time point. Cell adherence studies via FE‐SEM similar along flattened morphology extracellular matrix production. Therefore, based promising physico‐chemical properties, HEMA‐Chitosan exhibit strong potential application engineered biomaterials.

Language: Английский

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New Insights into Antiviral Natural Formulations: Biopolymeric Films for the Prevention and Treatment of a Wide Gamma of Viral Infections

Viruses, Journal Year: 2025, Volume and Issue: 17(2), P. 216 - 216

Published: Feb. 1, 2025

Viral infections remain a major concern, as existing treatments often yield inadequate responses or lead to the development of antiviral resistance in some cases. Fucoidan extracted from Undaria pinnatifida (F) is natural sulphated polysaccharide that exhibits action. Despite its potential, biomedical application F limited due difficult administration through trans-mucosal, skin, oral ingestion. The most effective way solve these problems propose novel methods aiming ensure better contact between biopolymers and pathogens, leading their inactivation. In this work, synthesis films based on chitosan (Ch)-coupled reported, generate synergic effect both terms antioxidant capability. Biocomposites were prepared by sonochemical method. They characterized infer structural properties, functionality, possible F-Ch interactions using Zeta FTIR, XRD techniques. biocomposites showed excellent film-forming ability. also exhibited improved activity with respect Ch individually proved be non-cytotoxic. These results demonstrate, for first time, F:Ch against bovine coronavirus human viruses (adenovirus, poliovirus, herpes simplex, respiratory syncytial virus), which could applied film form prevent treat viral infections.

Language: Английский

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