International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127357 - 127357
Published: Oct. 13, 2023
Language: Английский
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 290 - 348
Published: Sept. 28, 2023
Language: Английский
Citations
47
Journal of Molecular Graphics and Modelling, Journal Year: 2024, Volume and Issue: 128, P. 108702 - 108702
Published: Jan. 3, 2024
Language: Английский
Citations
19
Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(11), P. 9529 - 9543
Published: Sept. 23, 2023
Language: Английский
Citations
33
Frontiers in Nanotechnology, Journal Year: 2024, Volume and Issue: 6
Published: Oct. 21, 2024
Nanoparticles are attractive therapeutic tools due to their distinctive characteristics, including more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This review offers a comprehensive analysis of the potentials cutting-edge nanoparticles as demonstrated in human clinical trials, based on empirical evidence. Through systematic searches major scientific databases, relevant studies published up March 2024 were included, focusing trials utilizing advanced for purposes. The discusses diverse applications oncology, infectious diseases, neurology, other medical fields. Additionally, it scrutinizes safety profiles, efficacy outcomes, challenges associated with nanoparticle-based therapies. findings underscore significant progress translating nanoparticle research into practice highlight potential these innovative platforms revolutionize treatments. contributes valuable insights growing field therapeutics, fostering deeper understanding implications practice.
Language: Английский
Citations
16
Medicine in Drug Discovery, Journal Year: 2024, Volume and Issue: 22, P. 100183 - 100183
Published: March 8, 2024
Psoriasis is a chronic autoimmune disorder that has major effect on the quality of life for millions people throughout world. The pathogenesis psoriasis revealed intricate molecular networks and signaling pathways, opening new avenues precision medicine. treatments include topical therapy, phototherapy, systemic therapies, biologics, but achieving optimal outcomes difficult. Despite advancements in understanding causes development various treatments, optimizing therapeutic remains challenging. Managing poses challenges terms drug delivery evaluation models. Novel systems capable navigating complex skin barriers delivering therapeutics precisely to target cells are crucial advancing treatment options. This article provides an inclusive overview psoriasis, highlighting recent discoveries potential targets. emphasizes importance combining different modalities, such as synthetic herbal agents, with biologics improve efficacy. Nanocarriers show promise targeted they can encapsulate antipsoriatic drugs, gene providing enhanced stability, improved tissue penetration, precise cellular targeting. These have revolutionize by maximizing efficacy while minimizing side effects. also discusses commercial formulations, including patents related ongoing clinical trials, which provide valuable insights into evolving landscape therapeutics. provided contribute field offer hope patients suffering from psoriasis.
Language: Английский
Citations
12
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 199, P. 114298 - 114298
Published: April 18, 2024
Language: Английский
Citations
12
Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The deep interconnection between nucleic acids and carbohydrates has prompted numerous synthetic campaigns to understand acid etiology, develop orthogonal genetic systems, improve the properties of therapeutic oligonucleotides.
Language: Английский
Citations
1
Nanotechnology for Environmental Engineering, Journal Year: 2024, Volume and Issue: 9(2), P. 161 - 177
Published: March 21, 2024
Language: Английский
Citations
8
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133244 - 133244
Published: June 18, 2024
Language: Английский
Citations
6
ACS Chemical Health & Safety, Journal Year: 2024, Volume and Issue: 31(2), P. 127 - 143
Published: Feb. 9, 2024
For centuries, intranasal administration has been a perennial fascination for humanity. In recent times, the realm of nanotechnology-based biomaterials witnessed notable resurgence. At its epicenter is concept "nose-to-brain" delivery, pivotal strategy within pharmaceutical landscape aimed at circumventing challenges first-pass metabolism and reticular endothelium system. This innovative approach spans spectrum domains, encompassing drug diagnostics, theranostics, photothermal photodynamic therapies, bioengineering, biomedical engineering. To overcome multifaceted challenges, pioneering development novel formulations paramount, utilizing potential mucoadhesive polymers, sol–gel techniques, pH-dependent absorption, advanced methodologies. The evolution excipient technologies has, however, raised concerns surrounding nasal irritation, rapid drainage, systemic toxicity, affecting both established emerging formulations. Furthermore, growing interest in comprehending, evaluating, documenting toxicity profiles nanomaterials stems from their vast range applications across industries. It sheds light on various toxicological implications arising myriad variables dosage form formulations, including role excipients. crucial to note that mishandling devices designed formulation can significantly contribute concerns. Given these developments, this comprehensive review aims provide an exhaustive examination current knowledge regarding physiological consequences delivery systems human body.
Language: Английский
Citations
6