The regulatory effect of polysaccharides on the gut microbiota and their effect on human health: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132170 - 132170

Published: May 9, 2024

Language: Английский

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Prospects of yam (Dioscorea) polysaccharides: Structural features, bioactivities and applications

Food Chemistry, Journal Year: 2024, Volume and Issue: 446, P. 138897 - 138897

Published: Feb. 27, 2024

Language: Английский

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Dendrobium officinale regulate lipid metabolism in diabetic mouse liver via PPAR-RXR signaling pathway: Evidence from an integrated multi-omics analysis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116395 - 116395

Published: March 8, 2024

Dendrobium officinale (DEN) is recognized as a kind of functional food that can effectively ameliorate endocrine and metabolic disruptions. This study delved into the pharmacological mechanism DEN on hepatic lipotoxicity associated with Type II diabetes mellitus (T2DM). In vivo experiments db/db mice indicated treatment notably enhanced liver function, decreased blood lipid levels, improved insulin sensitivity. Non-targeted metabolomics analysis revealed significantly ameliorated metabolism pathways, including lipoic acid, linoleic bile secretion, alanine/aspartate/glutamate metabolism, well taurine hypotaurine metabolism. Transcriptomics demonstrated could modulate expression genes such Cpt1b, Scd1, G6pc2, Fos, Adrb2, Atp2a1, Ppp1r1b, Cyp7a1. Furthermore, Proteomics beneficial effect was linked to pathways like AMPK PPAR signaling. The integrative multi-omics PPAR-RXR signaling critical therapeutic T2DM-induced fatty liver. Additionally, in vitro AML-12 cells confirmed counteract PA-induced accumulation by activating pathway. Overall, these findings suggested exhibited potential mitigate lipo-toxicity manage imbalances T2DM.

Language: Английский

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Hypoglycemic effects of edible fungus polysaccharides: A mini review

Food & medicine homology., Journal Year: 2024, Volume and Issue: 2(1), P. 9420046 - 9420046

Published: Sept. 28, 2024

Language: Английский

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A review of in vitro antioxidant and antidiabetic polysaccharides: Extraction methods, physicochemical and structure-activity relationships

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137143 - 137143

Published: Nov. 3, 2024

Language: Английский

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Structural characterisation and hypoglycaemic effects on type 2 diabetic mice of Spirulina platensis polysaccharides and Se-modified polysaccharides

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105826 - 105826

Published: Jan. 1, 2025

Language: Английский

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A decade review on phytochemistry and pharmacological activities of Cynomorium songaricum Rupr.: Insights into metabolic syndrome

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156602 - 156602

Published: March 2, 2025

Language: Английский

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Structural characterization and hypoglycemic effect of polysaccharides of Polygonatum sibiricum

Journal of Food Science, Journal Year: 2024, Volume and Issue: 89(8), P. 4771 - 4790

Published: July 11, 2024

Polygonatum sibiricum polysaccharide (PSP) was extracted and purified from raw material obtained P. sibiricum. The structural features of PSP were investigated by Congo red, circular dichroism spectrum, high-performance gel permeation chromatography, scanning electron microscope, atomic force ultraviolet spectroscopy, Fourier transform infrared spectroscopy analysis. In vitro simulations conducted to investigate the kinetics enzyme inhibition. Moreover, a type II diabetes mouse model (T2DM) with streptozotocin-induced insulin resistance established, indexes lipid quadruple, index, oral glucose tolerance (OGTT), organ pancreatic morphology mice measured. results showed that mainly consists monosaccharides, such as mannose, glucose, galactose, xylose, arabinose. It also has β-glycosidic bond pyranose ring an irregular reticulated aggregated structure triple helix. inhibition assays revealed acts reversible competitive inhibitor α-glucosidase α-amylase. Furthermore, found reduce increase OGTT serum levels, decrease free fatty acid content improve metabolism, lower glycated protein enhance metabolism in T2DM mice, thereby leading reduction blood concentration. Additionally, exhibited reparative effects on damaged liver tissue cells mice. experiment provide preliminary basis for therapeutic mechanism about theoretical reference application food pharmaceutical development.

Language: Английский

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Polysaccharides from Inonotus obliquus employing subcritical water extraction: Extraction optimization, physiochemical properties and bioactivities analysis

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 222, P. 119638 - 119638

Published: Sept. 13, 2024

Language: Английский

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Optimization of the conditions for microwave-assisted hot-water extraction of polysaccharides from Cordyceps militaris and analysis of their hypoglycemic activity

Journal of Food Measurement & Characterization, Journal Year: 2024, Volume and Issue: 18(7), P. 5766 - 5778

Published: May 31, 2024

Language: Английский

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