Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Gels, Journal Year: 2024, Volume and Issue: 10(3), P. 190 - 190

Published: March 9, 2024

The repair of nervous tissue is a critical research field in engineering because the degenerative process injured system. In this review, we summarize progress injectable hydrogels using vitro and vivo studies for regeneration tissue. Traditional treatments have not been favorable patients, as they are invasive inefficient; therefore, promising treatment damaged This review will contribute to better understanding potential scaffolds drug delivery system neural applications.

Language: Английский

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Development of a Validated HPLC-UV Method for the Determination of Panthenol, Hesperidin, Rutin, and Allantoin in Pharmaceutical Gel-Permeability Study

Separations, Journal Year: 2025, Volume and Issue: 12(2), P. 19 - 19

Published: Jan. 22, 2025

A pressure ulcer is the necrosis of skin and tissues due to prolonged pressure. Its prevention treatment are great importance not only for health but also patient’s quality life considered highest priority. In present study, a reliable analytical method developed quantitative determination panthenol, hesperidin, rutin, allantoin by HPLC UV detectors. The substances were formulated into pharmaceutical gel, with healing regenerative properties recommended first- second-degree bedsores. Their separation was achieved ZIC-Hilic column (150 × 4.6 mm), 5 μm, gradient elution system (Solvent A: CH3CN-H2O, 90:10 v/v/v Solvent B: 10:90 v/v). evaluated based on required specifications (%RSD < 2, % Recovery > 96.7%) applied extraction active in gel. purification samples carried out using experimental design Cross-D-Optimal methodology 2.2, 96.9%). Subsequently, gel studied terms transdermal permeation ingredients (APIs) through vertical Franz cells their behavior (Papp values) compared similar aqueous suspension product (reference formulation). reconstituted lyophilization methanol. According results, drugs exhibit satisfactory penetration, ensuring problems that may occur dermis.

Language: Английский

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Advancing the understanding of diabetic encephalopathy through unravelling pathogenesis and exploring future treatment perspectives

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102450 - 102450

Published: Aug. 10, 2024

Language: Английский

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Unravelling neuroregenerative and neuroprotective roles of Wnt/β-catenin pathway in ischemic stroke: Insights into molecular mechanisms

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Application of stimuli-responsive hydrogel in brain disease treatment

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: July 18, 2024

Treating brain diseases presents significant challenges due to neuronal degeneration, inflammation, and the intricate nature of brain. Stimuli-responsive hydrogels, designed closely resemble brain’s extracellular matrix, have emerged as promising candidates for controlled drug delivery tissue engineering. These hydrogels unique ability encapsulate therapeutic agents release them in a manner when triggered by environmental stimuli. This property makes particularly suitable delivering drugs precisely targeted areas brain, while minimizing collateral damage healthy tissue. Their preclinical success treating various animal studies underscores their translational potential human disease treatment. However, deeper understanding long-term behavior, biodistribution, biocompatibility within remains crucial. Furthermore, exploring novel hydrogel systems combinations is paramount advancing towards more effective treatments. review summarizes latest advancements this field over past 5 years, specifically highlighting progress with stimuli-responsive diseases.

Language: Английский

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Advancements in Hydrogels for Corneal Healing and Tissue Engineering

Gels, Journal Year: 2024, Volume and Issue: 10(10), P. 662 - 662

Published: Oct. 16, 2024

Hydrogels have garnered significant attention for their versatile applications across various fields, including biomedical engineering. This review delves into the fundamentals of hydrogels, exploring definition, properties, and classification. Hydrogels, as three-dimensional networks crosslinked polymers, possess tunable properties such biocompatibility, mechanical strength, hydrophilicity, making them ideal medical applications. Uniquely, this article offers original insights application hydrogels specifically corneal tissue engineering, bridging a gap in current research. The further examines anatomical functional complexities cornea, highlighting challenges associated with pathologies reliance on donor corneas transplantation. Considering global shortage corneas, discusses potential hydrogel-based materials Emphasis is placed synthesis processes, physical chemical crosslinking, integration bioactive molecules. Stimuli-responsive which react to environmental triggers, are identified promising tools drug delivery repair. Additionally, clinical explored, showcasing efficacy trials. Finally, addresses regulatory approval need research fully realize offering outlook future developments field.

Language: Английский

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Nanotherapeutics for Meningitis: Enhancing Drug Delivery Across the Blood-Brain Barrier

Biomimetics, Journal Year: 2025, Volume and Issue: 10(1), P. 25 - 25

Published: Jan. 3, 2025

Meningitis is the acute or chronic inflammation of protective membranes, surrounding brain and spinal cord, this inflammatory process spreads throughout subarachnoid space. The traditional drug delivery methods pose a disadvantage in limiting capacity crossing blood–brain barrier (BBB) to reach central nervous system (CNS). Hence, it imperative develop novel approaches that can overcome these constraints offer efficient therapy for meningitis. Nanoparticle (NP)-based therapeutic have potential address limitations such as penetrating BBB achieving targeted release specific cells tissues. This review highlights recent advancements nanotechnology-based approaches, functionalized polymeric nanoparticles, solid lipid nanoparticles (SLNs), nanostructured carriers, nanoemulsions, liposomes, transferosomes, metallic NPs treatment Recently, bionics has emerged next-generation technology development ideas from biological principles, structures, interactions neurological neuroinfectious diseases. Despite their potential, more studies are needed ensure safety efficacy NP-based systems focusing on critical aspects toxicity, immunogenicity, pharmacokinetics. Therefore, addresses current strategies innovative nanoparticle discusses future directions meningitis therapies.

Language: Английский

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A multifunctional biomimetic double-layer composite hydrogel with wet adhesion and antioxidant activity for dural repair

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Feb. 10, 2025

Cerebrospinal fluid (CSF) leakage caused by accidents or diseases resulting from traumatic brain injury, inflammation, tumor erosion and surgery can lead to many complications. In this study, a multifunctional composite double-layer hydrogel was designed simulating the structure of native dura mater, which composed polyacrylic acid (PAA), polyethyleneimine (PEI), sodium alginate (SA), β-cyclodextrin (β-CD) edaravone (Ed). The PAA/PEI layer had strong wet adhesion characteristics, while PEI/SA@β-CD/Ed exhibited significant antioxidant, drug release biocompatibility properties. By controlling concentration Ca2+, gelation time be adjusted rapidly within 95-215 s. Specifically, final PAA/PEI/SA@β-CD/Ed porous network with high porosity low swelling rate, improved tensile strength, sufficient biodegradability, favourable performance, enhanced DPPH ABTS radicals scavenging abilities, sustained Ed capacity. addition, also showed excellent protective effect on H2O2-induced oxidative damage in SH-SY5Y cells. These results preliminarily suggested that would appear promising candidate for dural repair.

Language: Английский

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Peptide‐Based Strategies in PLGA‐Enhanced Tumor Therapy

Journal of Peptide Science, Journal Year: 2025, Volume and Issue: 31(6)

Published: April 23, 2025

ABSTRACT Peptide‐based therapeutics have gained attention in cancer treatment because of their good specificity, low toxicity, and ability to modulate immune responses. However, challenges such as enzymatic degradation poor bioavailability limit clinical application. Peptide‐functionalized poly(lactic‐co‐glycolic acid) (PLGA) systems emerged a transformative platform therapy that offers unique advantages, including enhanced stability, sustained release, precise delivery therapeutic agents. This review highlights the synergistic integration peptides with PLGA addresses key peptide‐based therapeutics. The application peptide‐functionalized encompasses diverse range strategies for therapy. In chemotherapy, disrupt critical tumor pathways, induce apoptosis, inhibit angiogenesis, demonstrating versatility targeting various aspects progression. immunotherapy, act antigens stimulate robust responses or checkpoint inhibitors restore T cell activity, overcoming evasion. These also harness permeability retention effect, facilitating preferential accumulation tissues while leveraging microenvironment (TME)‐responsive mechanisms, pH‐sensitive enzyme‐triggered drug achieve controlled, localized delivery. Collectively, represent promising, versatile approach integrates innovative highly specific, potent

Language: Английский

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Neurological insights into brain-targeted cancer therapy and bioinspired microrobots

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(9), P. 104105 - 104105

Published: Sept. 1, 2024

Language: Английский

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