Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 372, P. 123334 - 123334
Published: Nov. 16, 2024
Language: Английский
Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 339, P. 103425 - 103425
Published: Feb. 15, 2025
Language: Английский
Citations
2
Progress in Materials Science, Journal Year: 2025, Volume and Issue: unknown, P. 101460 - 101460
Published: Feb. 1, 2025
Language: Английский
Citations
2
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 28, 2025
Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in microenvironment of wound infection to promote healing. In this study, a multifunctional hydrogel delivery (HA@TA-Okra) was constructed through integration hyaluronic acid methacrylate (HAMA) matrix with tannic (TA) and okra extract. The composition structural characteristics HA@TA-Okra its unique advantages treatment diverse wounds were systematically evaluated. TA, due chemical structure, is able anchor within HAMA network interactions cross-linking, conferring exceptional mechanical strength stability hydrogel. Both TA extract possess antioxidant properties, when they two acts synergistically scavenge free radicals, enhance action, diminishing risk infection. vitro experiments revealed has superior such as rapid gel response, remarkable swelling regulation, potent ability. Furthermore, significantly outperformed conventional dressings terms hemostatic performance rat hemorrhage model. We further evaluated repair role vivo by establishing an animal model full-thickness skin defects infected total defects. results confirmed positive effects fighting bacterial infection, reducing inflammation promoting summary, exhibits comprehensive properties antibacterial, which potential application field tissue medicine. Graphical
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 12, 2025
Uncontrolled acute and persistent bleeding, as well with infection, is a great challenge because of the high mortality during treating patients injuries, complex surgery or bone marrow failure. Here, we develop an external form natural components which based on phosphorylated methacrylated gelatin (GelMA, G) cryogel (GP) loaded tannic acid (TA)-mixed copper ion (Cu2+) mesoporous bioactive glasses (MBG), named after GP@MBG-Cu-TA cryogel, to address goals reduce bleeding enhance antibacterial activity. Structurally, GP, MBG TA Cu2+ adheres GP via hydrogen bonding. In vitro, displays good biocompatibility, hemostatic antimicrobial capability. vivo studies, can effect in liver injury SD rats for aplastic anemia hemophilia A mice tail amputation bleeding. addition, accelerates skin wound repair bacterial contamination at site. sum, not only endowed dual function capability, but also stop objects either normal abnormal coagulation function. Thus, provides promising candidate dressing managing complications clinic.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133276 - 133276
Published: June 19, 2024
Language: Английский
Citations
4
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101628 - 101628
Published: March 2, 2025
Various pathological conditions (e.g., diabetes, osteoporosis) are accompanied by persistent oxidative stress, which compromises the immune microenvironment and poses substantial challenges for osseointegration. Reactive oxygen species (ROS) play a "double-edged sword" role in bone tissue. Therefore, developing responsive biomaterials to maintain redox balance dynamically is crucial enhanced Herein, microenvironment-responsive coordination nanoparticles (C-Ca-SalB NPs) composed of salvianolic acid B (SalB), catechol-conjugated chitosan (CS-C), Ca2+ constructed further covalently immobilized onto titanium implant surfaces. The resulting implants achieve on-demand antioxidant immunomodulatory effects manner, thus facilitating regeneration under both normal conditions. Under physiological conditions, functionalized display modest properties without affecting balance, while C-Ca-SalB NPs remain relatively stable. However, modified enable rapid decomposition acidic displaying robust ROS-scavenging, anti-inflammatory, osteoinductive capacities, ultimately remodeling into regenerative one. Overall, smart with controlled bioactive agent release this study present comprehensive solution enhancing bone-implant integration, particularly challenging context stress.
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Hemostatic materials should have efficient and rapid hemostasis, good biocompatibility, nontoxicity. However, common hemostatic sponges often fail due to their weak mechanical strength, low slow hemostasis. Herein, we developed novel multifunctional chitosan/cellulose/tannic acid (CS/OMCC/TA) biocomposite by a freeze-drying method without adding any chemical cross-linking agents. The water absorption rate of the sponge is as high 4404%, blood 5460%. In vitro coagulation tests shown that ability CS/OMCC/TA significantly better than commercial hemostasis materials. DPPH radical scavenging test antibacterial experiments demonstrated excellent antioxidant properties inhibitory effects on Staphylococcus aureus Escherichia coli. Animal showed could rapidly hemostasize within 185 s loss was 107 mg. These findings provide biocompatible for daily emergency trauma treatment surgical
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Plant polyphenol-based hydrogels, known for their biocompatibility and adhesive properties, have emerged as promising materials in biomedical applications. These hydrogels leverage the catechol group's ability to form stable bonds moist environments, similar mussel proteins. This review provides a comprehensive overview of synthesis, adhesion mechanisms, applications, particularly wound healing, tissue regeneration, drug delivery. However, challenges related vivo stability long-term remain critical barriers clinical translation. Future research should focus on enhancing bioactivity, biocompatibility, scalability these while addressing concerns toxicity, immune responses, large-scale manufacturing. Advances artificial intelligence-assisted screening 3D/4D bioprinting are expected accelerate development Furthermore, integration biomimetic designs responsive functionalities, such pH or temperature sensitivity, holds promise further improving therapeutic efficacy. In conclusion, multifunctional plant represents frontier advancing personalized medicine minimally invasive treatments.
Language: Английский
Citations
0
Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 372, P. 123334 - 123334
Published: Nov. 16, 2024
Language: Английский
Citations
0