Recent development of aptamer conjugated chitosan nanoparticles as cancer therapeutics

International Journal of Pharmaceutics, Journal Year: 2022, Volume and Issue: 620, P. 121751 - 121751

Published: April 15, 2022

Language: Английский

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Mechanisms of photodynamic therapy

Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 41 - 54

Published: Jan. 1, 2023

Language: Английский

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Bridging the gaps in cancer photothermal therapy through the intersection of nanotechnology and cell membrane coating

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149641 - 149641

Published: Feb. 15, 2024

Language: Английский

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Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 751 - 777

Published: July 4, 2024

Despite significant advances, cancer remains a leading global cause of death. Current therapies often fail due to incomplete tumor removal and nonspecific targeting, spurring interest in alternative treatments. Hyperthermia, which uses elevated temperatures kill cells or boost their sensitivity radio/chemotherapy, has emerged as promising alternative. Recent advancements employ nanoparticles (NPs) heat mediators for selective cell destruction, minimizing damage healthy tissues. This approach, known NP hyperthermia, falls into two categories: photothermal (PTT) magnetothermal (MTT). PTT utilizes NPs that convert light heat, while MTT magnetic activated by alternating fields (AMF), both achieving localized damage. These methods offer advantages like precise minimal invasiveness, reduced systemic toxicity. However, the efficacy hyperthermia depends on many factors, particular, properties, microenvironment (TME), TME-NP interactions. Optimizing this treatment requires accurate monitoring strategies, such nanothermometry biologically relevant screening models can better mimic physiological features human body. review explores state-of-the-art NP-mediated discussing available nanomaterials, strengths weaknesses, characterization methods, future directions. Our particular focus lies preclinical techniques, providing an updated perspective relevance journey towards clinical trials.

Language: Английский

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Metal-Decorated CeO2 nanomaterials for photocatalytic degradation of organic pollutants

Inorganic Chemistry Communications, Journal Year: 2022, Volume and Issue: 146, P. 110099 - 110099

Published: Oct. 14, 2022

Language: Английский

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Balancing the toxicity, photothermal effect, and promotion of osteogenesis: Photothermal scaffolds for malignant bone tumor therapy

Materials Today Advances, Journal Year: 2022, Volume and Issue: 13, P. 100209 - 100209

Published: Jan. 19, 2022

Malignant bone tumors have a high mortality rate and usually occur in adolescents. Postoperative chemotherapy often cannot completely eliminate the tumor tissue, regeneration is complex when cause large defects. Additionally, local systemic toxicity caused by can affect repair living quality of patient. Therefore, striking balance between therapy critical component anti-tumor research. Photothermal (PTT) has aroused interest researchers based on its potential to effects near-infrared (NIR)-based PTT therapy. The advantages NIR-triggered include ability penetrate decreased damage, ease control. This review focuses applying biomaterials with photothermal treating defects tumors. Specifically, toxicity, effect, promotion osteogenesis discussed for different scaffolds. provides reference information developing new generation malignant

Language: Английский

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How Did Conventional Nanoparticle-Mediated Photothermal Therapy Become “Hot” in Combination with Cancer Immunotherapy?

Cancers, Journal Year: 2022, Volume and Issue: 14(8), P. 2044 - 2044

Published: April 18, 2022

One of the promising cancer treatment methods is photothermal therapy (PTT), which has achieved good therapeutic efficiency through nanoparticle-based photoabsorbers. Because various functions nanoparticles, such as targeting properties, high light-to-heat conversion, and photostability, nanoparticle-mediated PTT successfully induces damage in tumor tissues with minimal side effects on surrounding healthy tissues. The efficacy originates from cell membrane disruption, protein denaturation, DNA by light-induced heat, but these biological impacts only influence localized areas. This conventional still attracts attention a novel immunotherapy, because causes immune responses against cancer. PTT-induced immunogenic death activates cells for systemic anti-cancer effect. Additionally, excellent compatibility other (e.g., chemotherapy checkpoint blockade therapy) reinforces combined immunotherapy. In this review, we investigate agents nanoparticles compare their applications to reveal how undergoes transition thermotherapy

Language: Английский

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Emerging innovations in cold plasma therapy against cancer: A paradigm shift

Drug Discovery Today, Journal Year: 2022, Volume and Issue: 27(9), P. 2425 - 2439

Published: May 19, 2022

Language: Английский

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Microparticulate and nanotechnology mediated drug delivery system for the delivery of herbal extracts

Journal of Biomaterials Science Polymer Edition, Journal Year: 2022, Volume and Issue: 33(12), P. 1531 - 1554

Published: April 11, 2022

There has been a growing interest in the scientific community to explore complete potential of phytoconstituents, herbal or plant-based ingredients owing range benefits they bring along. The plants accommodate many phytoconstituents that are responsible for various activities such as anti-oxidant, antimicrobial, anticancer, anti-inflammatory, anti-allergic, hepatoprotective, etc. However, these highly sensitive several environmental and physiological factors pH, oxygen, heat, temperature, humidity, stomach acid, enzymes, light. Hence, there is need development drug delivery system can protect from both internal external conditions. In this regard, microparticulate considered amongst ideal choice its small size, ability environment-sensitive active constituents, achieving sustained delivery, targeted protection conditions, minimizing drug-related side effects,

Language: Английский

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Nitrogen-doped carbon dots/curcumin nanocomposite for combined Photodynamic/photothermal dual-mode antibacterial therapy

Photodiagnosis and Photodynamic Therapy, Journal Year: 2022, Volume and Issue: 39, P. 103033 - 103033

Published: July 27, 2022

Language: Английский

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