Drug Delivery and Translational Research,
Journal Year:
2023,
Volume and Issue:
14(4), P. 895 - 917
Published: Oct. 16, 2023
Abstract
Hesperidin
(Hsd),
a
bioactive
phytomedicine,
experienced
an
antidiabetic
activity
versus
both
Type
1
and
2
Diabetes
mellitus
.
However,
its
intrinsic
poor
solubility
bioavailability
is
key
challenging
obstacle
reflecting
oral
delivery.
From
such
perspective,
the
purpose
of
current
study
was
to
prepare
evaluate
Hsd-loaded
sulfobutylether-β-cyclodextrin/chitosan
nanoparticles
(Hsd/CD/CS
NPs)
for
improving
hypoglycemic
orally
administered
Hsd.
Hsd
first
complexed
with
sulfobutylether-β-cyclodextrin
(SBE-β-CD)
complex
(CX)
found
be
formed
percent
complexation
efficiency
process
50.53
±
1.46
84.52
3.16%,
respectively.
Also,
solid
state
characterization
ensured
inclusion
inside
cavity
SBE-β-CD.
Then,
Hsd/CD/CS
NPs
were
prepared
using
ionic
gelation
technique.
The
fully
characterized
select
most
promising
one
(F1)
homogenous
particle
size
455.7
9.04
nm,
positive
zeta
potential
+
32.28
1.12
mV,
entrapment
77.46
0.39%.
optimal
formula
subjected
further
investigation
in
vitro
release,
ex
vivo
intestinal
permeation,
stability,
cytotoxicity,
activity.
results
release
permeation
studies
F1
manifested
modulated
pattern
between
CX.
preferential
stability
observed
at
4
°C.
biocompatibility
epithelial
cell
line
(OEC)
retained
up
concentration
100
µg/mL.
After
administration
F1,
noteworthy
synergistic
effect
recorded
decreased
blood
glucose
level
until
end
experiment.
In
conclusion,
could
regarded
as
hopeful
delivery
system
enhanced
Graphical
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Oct. 3, 2023
Lipid-based
polymeric
nanoparticles
are
the
highly
popular
carrier
systems
for
cancer
drug
therapy.
But
presently,
detailed
investigations
have
revealed
their
flaws
as
delivery
carriers.
Lipid
polymer
hybrid
(LPHNPs)
advanced
core-shell
nanoconstructs
with
a
core
region
enclosed
by
lipidic
layer,
presumed
to
be
derived
from
both
liposomes
and
nanounits.
This
unique
concept
is
of
utmost
importance
combinable
platform
in
oncology
due
its
dual
structured
character.
To
add
advantage
restrict
one's
limitation
other,
LPHNPs
been
designed
so
gain
number
advantages
such
stability,
high
loading
cargo,
increased
biocompatibility,
rate-limiting
controlled
release,
elevated
half-lives
well
therapeutic
effectiveness
while
minimizing
drawbacks.
The
outer
shell,
particular,
can
functionalized
variety
ways
stimuli-responsive
moieties
ligands
provide
intelligent
holding
active
targeting
antineoplastic
medicines,
transport
genes,
theragnostic.
review
comprehensively
provides
insight
into
recent
substantial
advancements
developing
strategies
treating
various
using
LPHNPs.
bioactivity
assessment
factors
also
highlighted
discussion
future
clinical
prospects.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Jan. 12, 2023
Pancreatic
cancer
(PC)
is
a
fatal
disease
that
has
poor
5-year
survival
rate.
The
prognosis
can
be
attributed
to
both
troublesome
detections
at
the
initial
stage,
which
makes
majority
of
treatment
options
largely
unsuccessful
and
leads
extensive
metastasis,
as
well
its
distinct
pathophysiological
characteristics,
such
rich
desmoplastic
tumours
bounded
by
dysplastic
hypo
perfused
vessels
restricting
mobility
therapeutic
agents.
Continued
attempts
have
been
made
utilise
innovative
measures
for
battling
PC
increase
effectiveness
therapies
overcome
their
cytotoxicity.
Combined
targeting
gene
silencing
approach
shown
improved
outcomes
in
patients'
rates
quality
life,
offering
potential
solution
complications.
It
particularly
targets
various
barriers
alleviate
delivery
problems
diminish
tumour
recurrence
metastasis.
While
aptamers,
type
single-stranded
nucleic
acids
with
strong
binding
affinity
specificity
target
molecules,
recently
surfaced
viable
strategy,
siRNA
interfere
expression
certain
genes.
By
concurrently
suppressing
genes
boosting
targeted
approach,
cocktail
siRNA/Aptamer
other
drugs
circumvent
multi-drug
resistance
phenomena.
Additionally,
combination
therapy
additive
or
synergistic
effects
considerably
efficacy
anti-cancer
medications.
This
study
outlines
primary
difficulties
treating
PC,
along
recent
developments
mediated
drug
solve
major
hiccup
oncology
field.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 255 - 255
Published: Feb. 9, 2024
Nanoparticles,
especially
gold
nanoparticles
(Au
NPs)
have
gained
increasing
interest
in
biomedical
applications.
Used
for
disease
prevention,
diagnosis
and
therapies,
its
significant
advantages
therapeutic
efficacy
safety
been
the
main
target
of
interest.
Its
application
immune
system
stability
physiological
environments
cell
membranes,
low
toxicity
optimal
bioperformances
are
critical
to
success
engineered
nanomaterials.
unique
optical
properties
great
attractors.
Recently,
several
physical
chemical
methods
coating
these
NPs
widely
used.
Biomolecules
such
as
DNA,
RNA,
peptides,
antibodies,
proteins,
carbohydrates
biopolymers,
among
others,
used
coatings
Au
various
applications,
thus
their
biocompatibility
while
maintaining
biological
functions.
This
review
mainly
presents
a
general
representative
view
different
types
NP
functionalization
using
biomolecules,
strategies
mechanisms.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 4275 - 4311
Published: July 1, 2023
Abstract:
Breast
cancer
(BC)
is
the
most
prevalent
type
of
in
world
and
main
reason
women
die
from
cancer.
Due
to
significant
side
effects
conventional
treatments
such
as
chemotherapy
radiotherapy,
search
for
supplemental
alternative
natural
drugs
with
lower
toxicity
interest
researchers.
Curcumin
(CUR)
a
polyphenol
extracted
turmeric.
Numerous
studies
have
demonstrated
that
CUR
an
effective
anticancer
drug
works
by
modifying
different
intracellular
signaling
pathways.
CUR's
therapeutic
utility
severely
constrained
its
short
half-life
vivo,
low
water
solubility,
poor
stability,
quick
metabolism,
oral
bioavailability,
potential
gastrointestinal
discomfort
high
doses.
One
practical
solutions
aforementioned
issues
development
targeted
delivery
systems
(TDDSs)
based
on
nanomaterials.
To
improve
targeting
efficacy
serve
reference
use
TDDSs
clinical
setting,
this
review
describes
physicochemical
properties
bioavailability
mechanism
action
BC,
emphasis
recent
BC
combination
CUR,
including
passive
TDDSs,
active
TDDSs.
Keywords:
breast
cancer,
curcumin,
system,
targeting,
Biosensors,
Journal Year:
2022,
Volume and Issue:
12(7), P. 462 - 462
Published: June 27, 2022
Wound
healing
is
a
complex
biological
phenomenon,
having
different
but
overlapping
stages
to
obtained
complete
re-epithelization.
The
aim
of
the
current
study
was
develop
dendrimer-based
hydrogel
bandage,
ameliorate
full-thickness
wounds.
Hesperidin,
bioflavonoid
found
in
vegetables
and
citrus
fruits,
used
for
treatment
wounds;
however,
its
therapeutic
use
limited,
due
poor
water
solubility
bioavailability.
This
issue
overcome
by
incorporating
hesperidin
inner
core
dendrimer.
Hence,
bandage
prepared,
wound
activity
determined.
A
hemolysis
indicated
that
hesperidin-loaded
dendrimer
biocompatible
can
be
healing.
efficacy
prepared
formulation
evaluated
on
wound,
using
an
animal
model.
H&E
staining
control
group
showed
degenerated
neutrophils
eosinophils,
while
10%
closure,
formation
epidermal
layer,
remodeling.
MT
better
collagen
synthesis
compared
group.
In
vivo
results
preparation
had
contraction
group;
after
14
days,
79
±
1.41,
98.9
0.42.
nutshell,
Hsp-P-Hyd
best
overall
performance
amelioration
