International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137756 - 137756
Published: Nov. 16, 2024
Language: Английский
Molecules, Journal Year: 2022, Volume and Issue: 27(15), P. 4818 - 4818
Published: July 27, 2022
Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack selectivity and serious side effects. hallmarks biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple a promising strategy to treat cancer. The diversity in chemical structure relatively low toxicity make plant-derived natural products source for development new more effective that have capacity target In this review, we discussed activities ten extracted from plants. majority these inhibit targeting hallmarks, many chemicals reached clinical applications. Studies review provide solid ground researchers physicians design combination using products.
Language: Английский
Citations
46
Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(2), P. 381 - 406
Published: Aug. 8, 2022
Bioactive compounds represent a broad class of dietary metabolites derived from fruits and vegetables, such as polyphenols, carotenoids glucosinolates with potential for cancer prevention. Curcumin, resveratrol, quercetin, β-carotene have been the most widely applied bioactive in chemoprevention. Lately, many approaches to encapsulating components nano-delivery systems improved biomolecules' stability targeted delivery. In this review, we critically analyze compounds, including polymeric nanoparticles (NPs), solid lipid (SLN), nanostructured carriers (NLC), liposomes, niosomes, nanoemulsions (NEs) use therapy. Efficacy studies nanoformulations using cell lines vivo models updated human clinical trials are also discussed. Nano-delivery were found improve therapeutic efficacy molecules against various types (e.g., breast, prostate, colorectal lung cancer) mainly due antiproliferation pro-apoptotic effects tumor cells. Furthermore, some promised combination therapy standard chemotherapeutic agents, increased efficiency fewer side effects. These opportunities identified developed ensure more excellent safety novel herbal medicines enabling insights designing
Language: Английский
Citations
46
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117180 - 117180
Published: July 27, 2024
Sepsis and septic shock are critical medical conditions characterized by a systemic inflammatory response to infection, significantly contributing global mortality rates. The progression multiple organ dysfunction syndrome (MODS) represents the most severe complication of sepsis markedly increases clinical mortality. Central pathophysiology sepsis, endothelial cells play crucial role in regulating microcirculation maintaining barrier integrity across various organs tissues. Recent studies have underscored pivotal function development sepsis-induced MODS. This review aims provide comprehensive overview MODS, with specific focus on dysfunction. It also compiles compelling evidence regarding potential small molecules that could attenuate subsequent multi-organ damage modulating function. Thus, this serves as an essential resource for practitioners involved diagnosing, managing, providing intensive care associated injuries, emphasizing importance targeting enhance outcomes patients.
Language: Английский
Citations
12
Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 3877 - 3898
Published: May 20, 2024
Abstract Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, berry fruits. It renowned for its several health advantages. The well known anticancer properties, substantial amount of clinical evidence has also established promise chemotherapeutic agent. This study focuses on assessing the properties resveratrol gaining insight into underlying molecular mechanisms. evaluates biopharmaceutical, toxicological characteristics, utilization to determine suitability further development reliable Therefore, information about preclinical studies was collected from different electronic databases up‐to‐date (2018–2023). Findings this revealed that potent therapeutic benefits against cancers involving mechanisms, induction oxidative stress, cytotoxicity, inhibition cell migration invasion, autophagy, arresting S phase cycle, apoptotic, anti‐angiogenic, antiproliferative effects by regulating pathways including PI3K/AKT, p38/MAPK/ERK, NGFR‐AMPK‐mTOR, so on. However, compound poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation resveratrol). Clinical application showed types cancer with no serious adverse effects. We suggest additional extensive check efficacy, safety, long‐term hazards. could involve larger number samples establish drug treatment cancer.
Language: Английский
Citations
10
Molecules, Journal Year: 2023, Volume and Issue: 28(10), P. 4080 - 4080
Published: May 13, 2023
The use of naturally derived drugs in anti-cancer therapies has grown exponentially recent years. Among natural compounds, polyphenols have shown potential therapeutic applications treatment due to their protective functions plants, as food additives, and excellent antioxidant properties, resulting beneficial effects on human health. Building more efficient cancer with fewer side health can be achieved by combining compounds conventional drugs, which are typically aggressive than chemicals polyphenols. This article reviews a wide variety studies where polyphenolic play key role anticancer alone or combination other drugs. Moreover, the future directions various therapy shown.
Language: Английский
Citations
22
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 4534 - 4534
Published: May 25, 2024
Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came attention of researchers both potential chemopreventive agent and possible explanation for low incidence cardiovascular disease (CVD) French people with high-fat diet. mainly administered food supplement, its properties are evaluated vitro vivo on various experimental models. modulates signaling pathways that limit spread tumor cells, protects nerve cells from damage, useful prevention diabetes, generally acts an anti-aging natural compound. It was highlighted could ameliorate consequences unhealthy lifestyle caused exaggerated caloric intake. This paper reviews evidence supporting beneficial effect pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, obesity, CVDs, immune bacterial, viral, fungal infections. The study also focused chromatographic analysis trans-RSV (tRSV) Romanian wine samples, providing comprehensive overview tRSV content across different types wine.
Language: Английский
Citations
7
Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 334 - 334
Published: March 10, 2024
Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.
Language: Английский
Citations
6
Food & Function, Journal Year: 2023, Volume and Issue: 14(23), P. 10286 - 10313
Published: Jan. 1, 2023
Herein, we review the current state-of-the-art on use of micro- and nano-delivery systems, a possible solution to some drawbacks associated with incorporation resveratrol in foods.
Language: Английский
Citations
15
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 1977 - 1977
Published: Jan. 19, 2023
Pancreatic cancer (PC) is one of the deadliest malignancies, with an increasing incidence and limited response to current therapeutic options. Therefore, more effective low-toxic agents are needed improve PC patients' outcomes. Resveratrol (RSV) a natural polyphenol multiple biological properties, including anticancer effects. In this study, we explored antiproliferative activities newly synthetized RSV analogues in panel cell lines evaluated physicochemical properties most active compound. This derivative exhibited marked effects cells through mechanisms involving DNA damage, apoptosis induction, interference cycle progression, as assessed using flow cytometry immunoblot analysis proteins, PARP cleavage, H2AX phosphorylation. Notably, compound induced consistent reduction subpopulation CD133+EpCAM+ stem-like phenotype, paralleled by dramatic on clonogenicity. Moreover, had negligible toxicity against normal HFF-1 and, thus, good selectivity index values toward lines. Remarkably, its higher lipophilicity stability human plasma, compared RSV, might ensure better permeation along gastrointestinal tract. Our results provide insights into action contributing activity synthetic analogue, supporting potential value search for safe treatment.
Language: Английский
Citations
14
Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: April 16, 2024
Language: Английский
Citations
5