Phytomedicine Plus, Journal Year: 2024, Volume and Issue: unknown, P. 100726 - 100726
Published: Dec. 1, 2024
Language: Английский
Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1000 - 1000
Published: Feb. 25, 2024
Quercetin is a flavonoid with low molecular weight that belongs to the human diet’s phenolic phytochemicals and nonenergy constituents. has potent antioxidant capacity, being able capture reactive oxygen species (ROS), nitrogen (RNS), chlorine (ROC), which act as reducing agents by chelating transition-metal ions. Its structure five functional hydroxyl groups, work electron donors are responsible for capturing free radicals. In addition its different pharmacological properties of quercetin have been described, such carcinostatic properties; antiviral, antihypertensive, anti-inflammatory ability protect low-density lipoprotein (LDL) oxidation, inhibit angiogenesis; these developed in this review.
Language: Английский
Citations
53
Published: Feb. 2, 2024
Quercetin is a flavonoid with low molecular weight that belongs to the human diet's phenolic phytochemicals and non-energy constituents. has potent antioxidant capacity, being able capture Reactive Oxygen Species (ROS), reactive nitro-gen species (RNS), Chlorine (ROC), which act as reducing agents by chelating transition metal ions. Its structure five functional hydroxyl groups, work electron donors are responsible for capturing free radicals. In addition its it was described different pharmacological properties of Quercetin, such carcinostatic properties, antiviral, antihypertensive, anti-inflammatory, protection Low-Density Lipoprotein (LDL) oxidation, inhibi-tion angiogenesis developed in this review.
Language: Английский
Citations
20
Nanotechnology Reviews, Journal Year: 2023, Volume and Issue: 12(1)
Published: Jan. 1, 2023
Abstract Green synthesis of zinc oxide (ZnO) nanoparticles (NPs) using various plant extracts as reducing and capping agents has gained attention in recent research. The green ZnO NPs offers several advantages such being simple, eco-friendly, safe, cost-effective, reproducible approach with high stability. Hence, this article provides an overview metal compounds, traditional chemical physical primary focuses on the NPs. This study discusses used proposed mechanisms Additionally, it explores cytotoxic green-synthesized addresses biomedical applications NPs, including antibacterial, anticancer, antidiabetic, antioxidant, antifungal, antiviral, antiparasitic, anti-inflammatory, wound healing. Moreover, review critically toxicity emphasizes need for more toxicological studies to ensure safety facilitate risk assessments management Furthermore, underlines challenges associated translation process from bench market, complex time-consuming regulatory approval which requires a multidisciplinary involving scientists, regulators, manufacturers.
Language: Английский
Citations
38
Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155707 - 155707
Published: May 10, 2024
Language: Английский
Citations
11
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 251 - 282
Published: Jan. 1, 2025
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1018 - 1018
Published: Feb. 23, 2025
Ferulic acid (FA) is a polyphenol that found in plants and fruits. It has wide range of anticancer properties, including participating cell apoptosis, inhibiting invasion angiogenesis, acting synergistically with standard cytostatic agents malignant tumors. A molecular mechanisms are involved activity include the following ones: activation cell-cycle-related proteins enzymes such as p53, p21, Bax, pro-caspases 3 9, reduction cyclin D1 E, proapoptotic Bcl-2, MMP-9, NF-kV, which decrease VEGF, leading to cycle arrest at G0/G1 phase death cancer cells. Other inhibit several pathways: PI3K/AKT/mTOR, Notch, Wnt, associated downregulation proliferation, invasion, metastasis, angiogenesis. FA can induce ROS, DNA damage In vitro vivo studies have demonstrated significant antitumor breast cancer, particularly when used combination agents. on cervical lines reported similar FA. This includes inhibition proliferation induction apoptosis by downregulating antiapoptotic proteins. case-control study conducted Italy men histologically confirmed prostate had notably lower levels compared controls. Molecular suggested may various effects signaling pathways linked risk it act synergy δ-tocotrienol, derivative vitamin E. colorectal early development this cancer-inhibition abnormal crypt foci (ACF-aberrant foci), well viability through changes, mainly EGFR expression. The poor water solubility makes an attractive candidate for use nanoparticles.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 5, 2025
Colorectal cancer (CRC) is a common malignant tumor of the digestive system, and pathogenic mechanism still unclear, mostly related to genetics, immunity, inflammation, abnormal activation tumor-related signaling pathways. MAPK belongs Ser/Thr kinase family, which plays an important role in complex cellular programs such as regulation cell proliferation, differentiation, apoptosis, angiogenesis, metastasis. Increasing evidence supports that highly correlated with risk CRC. Targeting may be therapeutic strategy, natural products show great potential regulating MAPK-related proteins. In this paper, we searched PubMed, Web Science CNKI databases keywords "colorectal cancer, products, pathway, ERK, P38, JNK" for relevant studies last 14 years from 2010 2024. This work retrieved 47 studies, aiming provide new strategies CRC patients lay foundation drug development.
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: July 3, 2024
Introduction Antibiotic resistance represents one of the most significant threats to public health in 21st century. Polyphenols, natural molecules with antibacterial activity produced by plants, are being considered as alternative antimicrobial strategies manage infections caused drug-resistant bacteria. In this study, we investigated a polyphenol mixture extracted from citrus fruits, against both antibiotic-susceptible and resistant strains Staphylococcus aureus epidermidis . Methods Broth microdilution time-kill curve experiments were used test extract anti-staphylococcal activity. Cytotoxicity was assessed hemolysis assay. The interaction between antibiotics checkerboard effect B alone combination oxacillin on membrane potential 3,3′-dipropylthiadicarbocyanine iodide ability induce development verified propagating S. for 10 transfers presence sub-inhibitory concentrations. Results found be active all at remarkably low concentrations (0.0031 0.0063%), displaying rapid bactericidal effects without toxic erythrocytes. particular, rapidly cause depolarization. When combined methicillin, meropenem, oxacillin, displayed synergistic exclusively methicillin-resistant strains. We additionally show that sequential exposure did not extract. Discussion Overall, these findings support use promising option staphylococcal suggest it may counteract mechanism behind methicillin-resistance.
Language: Английский
Citations
3
Biomass Conversion and Biorefinery, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 5, 2024
Language: Английский
Citations
3
Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1166 - 1166
Published: Sept. 18, 2024
Cardamom (cardamum) is a spice produced from the seeds of several Elettaria and Amomum plants Zingiberaceae family. has been demonstrated to offer numerous benefits, including its antioxidant, antimicrobial, anti-inflammatory, other metabolic (anti-diabetic) properties, potential reduce cancer risk. Recently, researchers have extracted tested multiple phytochemicals cardamom assess their effectiveness against various types human malignancy. These studies indicated that can help overcome drug resistance standard chemotherapy protect chemotherapy-induced toxicity due scavenging properties. Furthermore, chemical compounds in cardamom, limonene, cymene, pinene, linalool, borneol, cardamonin, indole-3-carbinol, diindolylmethane, primarily target programmed cell death lignin-1 gene, which more prevalent cells than healthy cells. This review provides medicinal properties pharmacological uses cellular effects, therapeutic prevention treatment, as well use reducing improving overall health patients. Based on previous preclinical studies, shows significant an anti-cancer agent, but further exploration for clinical warranted diverse mechanisms action.
Language: Английский
Citations
3