Lipidic and Inorganic Nanoparticles for Targeted Glioblastoma Multiforme Therapy: Advances and Strategies

Micro, Journal Year: 2025, Volume and Issue: 5(1), P. 2 - 2

Published: Jan. 3, 2025

Due to their biocompatibility, nontoxicity, and surface conjugation properties, nanomaterials are effective nanocarriers capable of encapsulating chemotherapeutic drugs facilitating targeted delivery across the blood–brain barrier (BBB). Although research on nanoparticles for brain cancer treatment is still in its early stages, these systems hold great potential revolutionize drug delivery. Glioblastoma multiforme (GBM) one most common lethal tumors, heterogeneous aggressive nature complicates current treatments, which primarily rely surgery. One significant obstacles poor penetration BBB. Moreover, GBM often referred as a “cold” tumor, characterized by an immunosuppressive tumor microenvironment (TME) minimal immune cell infiltration, limits effectiveness immunotherapies. Therefore, developing novel, more treatments critical improving survival rate patients. Current strategies enhancing outcomes focus controlled, agents cells BBB using nanoparticles. These therapies must be designed engage specialized transport systems, allowing efficient penetration, improved therapeutic efficacy, reduced systemic toxicity degradation. Lipid inorganic can enhance while minimizing side effects. formulations may include epitopes—small antigen fragments that bind directly free antibodies, B receptors, or T receptors—that interact with enable crossing, thereby boosting efficacy. Lipid-based (LNPs), such liposomes, niosomes, solid lipid (SLNs), nanostructured carriers (NLCs), among promising due unique including size, modification capabilities, proven biosafety. Additionally, gold nanoparticles, mesoporous silica, superparamagnetic iron oxide dendrimers offer alternatives. Inorganic (INPs) easily engineered, surfaces modified various elements biological ligands delivery, biocompatibility. Strategies engineering functionalization have been employed ensure biocompatibility reduce cytotoxicity, making safer clinical applications. The use INPs has shown promise efficacy traditional like chemotherapy, radiotherapy, gene therapy, well advancing newer strategies, immunotherapy, photothermal photodynamic therapies, magnetic hyperthermia. This article reviews latest treating GBM, focusing active passive targeting approaches.

Language: Английский

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Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 1, 2025

Language: Английский

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Biomolecule-based engineered nanoparticles for Cancer Theranostics

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489

Published: Feb. 3, 2025

Language: Английский

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Lipid-Based Nanocarriers: Bridging Diagnosis and Cancer Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1158 - 1158

Published: Sept. 1, 2024

Theranostics is a growing field that matches diagnostics and therapeutics. In this approach, drugs techniques are uniquely coupled to diagnose treat medical conditions synergically or sequentially. By integrating diagnostic treatment functions in single platform, the aim of theranostics improve precision medicine by tailoring treatments based on real-time information. context, lipid-based nanocarriers have attracted great scientific attention due their biodegradability, biocompatibility, targeting capabilities. The present review highlights latest research advances for cancer theranostics, exploring several ways improving vivo performance addressing associated challenges. These significant potential create new perspectives nanomedicine offer promise step towards more personalized precise medicine, reducing side effects clinical outcomes patients. This also presents actual barriers possible challenges use nanoparticles theranostic field, such as regulatory hurdles, high costs, technological integration. Addressing these issues through multidisciplinary collaborative approach among institutions could be essential advancing lipid field. Such collaborations can leverage diverse expertise resources, fostering innovation overcoming complex with translation. will crucial realizing full medicine.

Language: Английский

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Enhanced Therapy for Diabetic Neuropathy Utilizing Venlafaxine Hydrochloride-Loaded Transferosome-Based Transdermal Gel

Nano Trends, Journal Year: 2025, Volume and Issue: 9, P. 100085 - 100085

Published: Jan. 31, 2025

Language: Английский

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A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125385 - 125385

Published: Feb. 1, 2025

Language: Английский

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Lipid-based nanoparticles for nucleic acids delivery

Physical Sciences Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract This chapter highlights challenges and advancements in the production of lipid-based nanoparticles (LNPs) their application nucleic acid-based therapies. Recently, mRNA-based vaccines for COVID-19 immunization revealed that use acids is a promising strategy to develop treatments at high therapeutic efficiency reduced side effects. In this context, LNPs emerged as favourable vehicles delivery (like mRNA DNA), due biocompatibility, bioavailability, versatility. The four main components employed produce loaded with are: cationic or ionizable lipids, helper cholesterol, PEGylated lipids. Several conventional techniques have been proposed over years kind nanoparticles. However, they show many drawbacks hinder direct vesicles characterized by nanometric size, encapsulation active pharmaceutical ingredient, prolonged stability. Processes assisted supercritical fluids (in particular, CO 2 ) can represent sustainable interesting alternative without using post-processing steps solvent removal size reduction are time-consuming procedures, lead large loss acids, negatively influence general productivity process.

Language: Английский

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Transferosome-Enhanced Transdermal Therapy: A Novel Approach for Duloxetine Delivery for Management of Neuropathic Pain

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 17, 2025

Language: Английский

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Investigating the apoptotic and antimetastatic effect of daphnetin-containing nano niosomes on MCF-7 cells

Advances in Cancer Biology - Metastasis, Journal Year: 2025, Volume and Issue: unknown, P. 100139 - 100139

Published: April 1, 2025

Language: Английский

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Transfersomes: a next-generation drug delivery system for topical ocular drug delivery

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

The eye is a complex organ with several anatomical and physiological barriers that make ocular drug delivery an ongoing challenge. Transfersomes (TFS) are deformable vesicles have extensively been applied to enhance transdermal delivery. However, their application in remains largely unexplored. This review highlights the challenges typically associated emphasizes inherent properties of TFS enable them overcome these challenges. influence excipients critical process parameters on characteristics discussed detail emphasis fabrication characterization techniques employed for development optimization. Furthermore, recent studies evaluating depth. unique stress-responsive nature makes promising carriers further research this direction needed understand penetration mechanism elucidate potential sustained targeted tissues. Moreover, optimize stability scalability encourage translation market.

Language: Английский

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