Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 24, 2024
Abstract
Retinol
and
retinyl
palmitate,
with
excellent
whitening
antioxidant
activities,
are
widely
used
as
essential
functional
ingredients
in
transdermal
preparations
skincare
products.
Herein,
for
the
first
time,
influence
underlying
mechanisms
of
retinol
palmitate
on
skin
penetration
caffeine
investigated.
It
is
found
that
very
significantly
enhanced
by
2.83
2.57
folds,
respectively.
Mechanistic
studies
showed
they
can
disrupt
lipids
intercellular
orderly
arrangement
reduce
content
orthorhombic
lattices
skin,
making
loose
barrier
function
decreased.
Furthermore,
due
to
formation
chemical
bonds
keratin,
have
a
strong
affinity
changing
dense
secondary
structure
keratin
reduced
effect.
This
study
provides
new
evidence
potential
novel
enhancers
high
safety
possess
great
application
delivery
pharmaceutical
cosmetic
active
substances.
Plants,
Journal Year:
2023,
Volume and Issue:
12(14), P. 2661 - 2661
Published: July 16, 2023
Transdermal
delivery
devices
and
wound
dressing
materials
are
constantly
improved
upgraded
with
the
aim
of
enhancing
their
beneficial
effects,
biocompatibility,
biodegradability,
cost
effectiveness.
Therefore,
researchers
in
field
have
shown
an
increasing
interest
using
natural
compounds
as
constituents
for
such
systems.
Plants,
important
source
so-called
“natural
products”
enormous
variety
structural
diversity
that
still
exceeds
capacity
present-day
sciences
to
define
or
even
discover
them,
been
part
medicine
since
ancient
times.
However,
benefits
just
at
beginning
being
fully
exploited
modern
dermal
transdermal
Thus,
plant-based
primary
compounds,
without
biological
activity,
contained
gums
mucilages,
traditionally
used
gelling
texturing
agents
food
industry,
now
explored
valuable
cost-effective
components
biomedical
field.
Their
non-toxicity
compensate
local
availability
compositional
variations.
Also,
secondary
metabolites,
classified
based
on
chemical
structure,
intensively
investigated
wide
pharmacological
toxicological
effects.
impact
is
highlighted
detail
through
most
recent
reported
studies.
Innovative
isolation
purification
techniques,
new
drug
systems,
advanced
evaluation
procedures
presented.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
Abstract
Sigal
peptides
have
garnered
remarkable
efficacy
in
rejuvenating
photoaged
skin
and
delaying
senescence.
Nevertheless,
their
low
solubility
poor
permeability
bring
about
a
formidable
challenge
transdermal
delivery.
To
address
this
challenge,
bioactive
ionic
liquids
(ILs)
synthesized
from
natural
glycyrrhizic
acid
(GA)
oxymatrine
(OMT)
with
eminent
biocompatibility
is
first
prepared.
The
components
ratios
inherent
forming
mechanisms
of
GA‐OMT
(GAO)
are
optimized
by
molecular
dynamics
simulations
density
functional
theory
calculations.
Remarkably,
GAO
can
significantly
improve
the
sparingly
soluble
properties
palmitoyl
pentapeptide‐4
(PAL‐4),
model
peptide
drug.
Subsequently,
self‐assembled
micelles
loading
PAL‐4
(GAO/PAL‐4‐SM)
fabricated
without
additional
auxiliary
materials.
permeation
subcutaneous
retention
promoted
10wt.%
GAO‐SM.
Moreover,
ILs
facilitated
enhancing
its
miscibility
interaction
stratum
corneum
(SC),
offering
pulling
effect
micellar
structures
for
PAL‐4,
as
elucidated
computational
simulations.
In
cellular
animal
photoaging
experiments,
GAO/PAL‐4‐SM
possessed
capabilities
boosting
collagen
hyaluronic
regeneration,
mitigating
inflammation
apoptosis,
accelerating
macrophage
M2
polarization,
thereby
lessening
wrinkles
leveraging
elasticity.
Collectively,
research
innovatively
designed
an
nano‐micellar
delivery
system
to
enhance
anti‐photoaging
signal
peptides.
Advanced Therapeutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 9, 2025
Abstract
Conventional
drug
delivery
methods
often
face
challenges
in
terms
of
patient
adherence
and
administration.
Microneedles
(MNs)
patches
have
emerged
as
a
promising
alternative,
offering
minimally
invasive
transdermal
route
for
medications.
However,
their
drug‐loading
capacity
remains
limited,
particularly
hydrophobic
active
pharmaceutical
ingredients
(APIs).
Herein,
microneedles
are
designed
based
on
eutectic
solvent
gels
(eutectogels)
carriers
APIs.
A
natural
deep
(NADES)
is
combined
to
enhance
the
solubility
APIs
within
GelMA/PEGDA
matrix
mechanical
strength
sustained
release
from
resulting
eutectogels
(EU‐MNs).
Using
docetaxel,
5‐fluorouracil,
curcumin
models,
superior
EU‐MNs
demonstrated.
In
vitro
experiments
revealed
that
provided
distinct
over
4
days.
Additionally,
by
properly
adjusting
concentration
type
APIs,
these
microneedle
do
not
exhibit
cytotoxic
effects
fibroblasts
cell
line
(NIH/3T3),
underscoring
potential
safe
effective
delivery.
These
findings
highlight
versatile,
eco‐friendly
vehicles
large
amounts
leading
more
treatments
drugs.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(12), P. 8977 - 8985
Published: Jan. 1, 2025
The
scattering
techniques,
including
small-angle
X-ray
and
neutron
scattering,
revealed
how
DES
concentration
skin
hydration
affect
stratum
corneum
lipid
structure
drug
carrier
penetration.
Drug Delivery,
Journal Year:
2025,
Volume and Issue:
32(1)
Published: April 21, 2025
Low
solubility
restricted
transdermal
penetration
of
drugs.
We
aimed
to
develop
a
novel
ionic
liquid-iontophoresis
(IL-IS)
technology
and
assess
their
efficacy
primary
factors
in
facilitating
drug
delivery.
Five
choline-based
ILs
with
different
chain
length
were
synthesized
validated,
the
impact
IL
and/or
IS
on
model
drugs
investigated.
The
results
indicated
that
five
groups
this
study
exhibited
minimal
level
toxicity,
longer
acid
ligands
ILs,
greater
cytotoxicity.
ligand
was
demonstrated
superior
solubilizing
capabilities
compared
shorter
chain.
Cinnamic
acid-choline-based
([Cho]
[Cin])
significantly
improved
permeation
all
three
drugs,
quantity
linearly
positively
associated
concentration
ILs.
10
h
cumulative
aripiprazole
applied
alone
enhanced
by
about
14-fold
when
paired
IS,
current
strength
In
vivo
primarily
facilitated
into
skin,
potential
involvement
endocytosis
process.
This
[Cho]
[Cin]
significant
enhancement
delivery
sparingly
soluble
It
further
weak
base
following
combining
technology.
These
findings
highlighted
IL-IS
holded
promise
for
Crystal Growth & Design,
Journal Year:
2024,
Volume and Issue:
24(13), P. 5593 - 5602
Published: June 13, 2024
Cocrystallization
has
emerged
as
a
promising
strategy
to
obtain
new
solid
forms
of
given
compound
with
tailored
properties.
In
this
study,
green
and
efficient
slurry
method
was
proposed
for
cocrystal
synthesis
using
deep
eutectic
solvents
(DESs),
generation
solvents,
both
the
solvent
reactant
(i.e.,
coformer).
The
subjected
screening
carbamazepine
in
series
choline
chloride
(ChCl)
DESs
compared
organic
solvents.
results
indicate
that
formation
by
is
similar
solvate
it
can
overcome
issues
traditional
cocrystallization
such
individual
crystallization
caused
solubility
differences
unwanted
solvates,
thereby
improving
efficiency
cocrystals.
Further,
DES
ChCl
urea
used
30
compounds,
all
cocrystals
were
successfully
synthesized
after
reaction
temperature
water
contents
adjusted,
further
confirming
applicability
various
compounds.
Finally,
artificial
bee
colony
algorithm,
one
intelligence,
adopted
search
low-energy
stable
structures
precursors
ChCl-urea
DESs.
Such
combined
hydrogen
bond
analysis
Atoms
Molecules
theory
indicated
strong
interactions
between
drug
could
restrain
its
urea.
conclusion,
based
on
study
obstacles
which
green,
efficient,
alternative
synthesis.
