Role of ferroptosis in the occurrence and progression of acute ischemic stroke DOI Open Access
H Li, Bin Meng,

Zhongqiang Cheng

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: June 8, 2023

Ferroptosis is a new non-apoptotic form of regulatory cell death, which characterized by intracellular iron overload and excessive accumulation lipid peroxides reactive oxygen species (ROS). closely related to iron, amino acid, metabolism disorders. increasingly recognized as an important process mediating the pathogenesis progression acute ischemic stroke, it can be involved in influencing stroke risk factors atherosclerosis, atrial fibrillation, hypertension, diabetes mellitus, obstructive sleep apnea. Therefore, understanding mechanisms ferroptosis regulation different diseases may have significant implications for preventive treatment improvement prognosis patients with stroke. This article reviews not only specific development but also relevant associations between ferroptosis, describes current limitations future directions its factors.

Language: Английский

Cancer-associated fibroblasts impair the cytotoxic function of NK cells in gastric cancer by inducing ferroptosis via iron regulation DOI Creative Commons

Lizhong Yao,

Junyi Hou,

Xiongyan Wu

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 67, P. 102923 - 102923

Published: Oct. 6, 2023

As the predominant immunosuppressive component within tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) inhibit Natural Killer cell (NK cell) activity to promote progression and immune escape; however, mechanisms of cross-talk between CAFs NK cells in gastric cancer (GC) remain poorly understood. In this study, we demonstrate that levels are inversely correlated with abundance human GC. impair anti-tumor capacity by inducing ferroptosis, a death process characterized accumulation iron-dependent lipid peroxides. induce ferroptosis promoting iron overload; conversely, decreased intracellular protect against CAF-induced ferroptosis. Mechanistically, increase labile pool via export into TME, which is mediated upregulated expression regulatory genes ferroportin1 hephaestin CAFs. Moreover, CAF-derived follistatin like protein 1(FSTL1) upregulates NCOA4 DIP2A-P38 pathway, NCOA4-mediated ferritinophagy required for patient-derived organoid model, functional targeting using combination deferoxamine FSTL1-neutralizing antibody significantly alleviate boost cytotoxicity This study demonstrates novel mechanism suppression TME presents potential therapeutic approach augment response GC cells.

Language: Английский

Citations

48
The mechanisms of ferroptosis and its role in atherosclerosis DOI Open Access

Xi Xu,

Xiaodan Xu, Mengqing Ma

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 171, P. 116112 - 116112

Published: Jan. 2, 2024

Ferroptosis is a newly identified form of non-apoptotic programmed cell death, characterized by the iron-dependent accumulation lethal lipid reactive oxygen species (ROS) and peroxidation membrane polyunsaturated fatty acid phospholipids (PUFA-PLs). unique among other death modalities in many aspects. It initiated excessive oxidative damage due to iron overload compromised antioxidant defense systems, including system Xc-/ glutathione (GSH)/glutathione peroxidase 4 (GPX4) pathway GPX4-independent pathways. In past ten years, ferroptosis was reported play critical role pathogenesis various cardiovascular diseases, e.g., atherosclerosis (AS), arrhythmia, heart failure, diabetic cardiomyopathy, myocardial ischemia-reperfusion injury. Studies have dysfunctional metabolism abnormal expression profiles ferroptosis-related factors, iron, GSH, GPX4, ferroportin (FPN), SLC7A11 (xCT), as indicators for atherogenesis. Moreover, plaque cells, i.e., vascular endothelial (VEC), macrophage, smooth muscle (VSMC), positively correlate with atherosclerotic development. Many macromolecules, drugs, Chinese herbs, food extracts can inhibit atherogenic process suppressing cells. contrast, some inducers significant pro-atherogenic effects. However, mechanisms through which affects progression AS still need be well-known. This review summarizes molecular their emerging AS, aimed at providing novel, promising druggable targets anti-AS therapy.

Language: Английский

Citations

41
Atherosclerotic Cardiovascular Disease in Cancer Survivors: Current Evidence, Risk Prediction, Prevention, and Management DOI Creative Commons
Arum Choi, Subin Kim, Seonji Kim

et al.

Journal of Lipid and Atherosclerosis, Journal Year: 2025, Volume and Issue: 14(1), P. 30 - 30

Published: Jan. 1, 2025

While advances in cancer treatment have led to improved survival rates, survivors are at a significant risk of developing atherosclerotic cardiovascular disease (ASCVD). This review examines the risk, diagnosis, and prevention ASCVD this population. Cancer survivors, especially those diagnosed with certain types, face significantly higher than general We introduce "triad model" explain increased among patients. model includes three interconnected components: common catalysts, influence, impact. The factors contributing shared between ASCVD, such as smoking, obesity, systemic inflammation; direct effects on health through chronic inflammation endothelial damage; anticancer treatments, including chemotherapy radiation, which can worsen complications hasten progression ASCVD. Furthermore, dying from highlighting necessity for tailored guidelines strategies management explores utility diagnostic tools, coronary artery calcium scoring, predicting managing risk. It also emphasizes importance that include regular monitoring lifestyle modifications. Finally, relationship highlights integrated comprehensive care approaches. Continued research, development prediction models, specific preventative essential improve survivors' overall outcomes.

Language: Английский

Citations

2
Ferroptosis: a potential target for the treatment of atherosclerosis DOI Creative Commons
Chengyi Li, Ran Liu, Zhenyu Xiong

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 26, 2024

Atherosclerosis (AS), the main contributor to acute cardiovascular events, such as myocardial infarction and ischemic stroke, is characterized by necrotic core formation plaque instability induced cell death. The mechanisms of death in AS have recently been identified elucidated. Ferroptosis, a novel iron-dependent form death, has proven participate atherosclerotic progression increasing endothelial reactive oxygen species (ROS) levels lipid peroxidation. Furthermore, accumulated intracellular iron activates various signaling pathways or risk factors for AS, abnormal metabolism, oxidative stress, inflammation, which can eventually lead disordered function macrophages, vascular smooth muscle cells, cells. However, molecular through ferroptosis affects development are not entirely understood. This review systematically summarizes interactions between provides feasible approach inhibiting from perspective ferroptosis.

Language: Английский

Citations

10
Ferroptosis induced by environmental pollutants and its health implications DOI Creative Commons
Fu‐Han Gong, Liyuan Liu,

Xuesheng Wang

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 24, 2025

Abstract Environmental pollution represents a significant public health concern, with the potential risks associated environmental pollutants receiving considerable attention over an extended period. In recent years, substantial body of research has been dedicated to this topic. Since discovery ferroptosis, iron-dependent programmed cell death typically characterized by lipid peroxidation, in 2012, there have advances study its role and mechanism various diseases. A growing number studies also demonstrated involvement ferroptosis damage caused organism pollutants, molecular mechanisms involved partially elucidated. The targeting be effective means ameliorating PM2.5, organic inorganic ionizing radiation. This review begins providing summary most important ferroptosis. It then proceeds offer critical analysis effects induced pollutants. Furthermore, as is case all rapidly evolving areas, are numerous unanswered questions challenges pertaining pollutant-induced which we discuss attempt provide some directions clues for future field.

Language: Английский

Citations

1
Ferroptosis in age-related vascular diseases: Molecular mechanisms and innovative therapeutic strategies DOI Open Access
Yue Dai, Xiuxian Wei, Tao Jiang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116356 - 116356

Published: Feb. 29, 2024

Aging, an inevitable aspect of human existence, serves as one the predominant risk factors for vascular diseases. Delving into mystery disease's pathophysiology, profound involvement programmed cell death (PCD) has been extensively demonstrated. PCD is a fundamental biological process that plays crucial role in both normal physiology and pathology, including recently discovered form, ferroptosis. Ferroptosis characterized by its reliance on iron lipid peroxidation, significant disease pathophysiology increasingly acknowledged. This phenomenon not only offers promising therapeutic target but also deepens our understanding complex relationship between ferroptosis age-related Consequently, this article aims to thoroughly review mechanisms enable effective control inhibition It focuses genetic pharmacological interventions, with goal developing innovative strategies combat

Language: Английский

Citations

6
Cannabidiol mitigates radiation-induced intestine ferroptosis via facilitating the heterodimerization of RUNX3 with CBFβ thereby promoting transactivation of GPX4 DOI

Congshu Huang,

Liangliang Zhang, Pan Shen

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 222, P. 288 - 303

Published: June 1, 2024

Language: Английский

Citations

4
Mechanisms and therapeutic target of anti-tumour treatment-related Ferroptosis: How to improve cancer therapy? DOI Open Access
Xiangyu Zhou, Lin Lin

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117323 - 117323

Published: Aug. 28, 2024

Recently, increased attention has been focused on the regulatory mechanism and potential clinical application of ferroptosis in cancer cells, especially therapy-related ferroptosis. However, treatment-related prospects strategies for future treatment still require further clarification. This review highlights molecular relationships between different antitumour drugs, including commonly used chemotherapy radiation therapy vitamins, also proposes treatments that involve ferroptosis, with an aim to develop a new strategy transformative emerging field improve therapy.

Language: Английский

Citations

4
Atherosclerotic Cardiovascular Disease in Cancer Survivors: Current Evidence, Risk Prediction, Prevention, and Management DOI Creative Commons
Arum Choi, Subin Kim, Seonji Kim

et al.

Journal of Lipid and Atherosclerosis, Journal Year: 2025, Volume and Issue: 14(1), P. 22 - 22

Published: Jan. 1, 2025

Language: Английский

Citations

0
Carotid artery stenosis and ischemic cerebrovascular events after radiotherapy in patients with head and neck cancer DOI Creative Commons
Nawaphan Taengsakul, Padungcharn Nivatpumin,

Thong Chotchutipan

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0314861 - e0314861

Published: Jan. 30, 2025

Radiotherapy is the main treatment for patients with head and neck cancer (HNC) associated an increased risk of ischemic cerebrovascular events (ICVE). The purpose this cross-sectional study was to determine incidence ICVE carotid artery stenosis (CAS) in HNC who receive radiotherapy factors CAS. We enrolled 907 underwent between February 2011 June 2022 obtained information on their clinical tumor characteristics from records. Data atherosclerosis, medications used, were also collected. followed through end 2023 unless they died or lost follow-up. overall 1.98%, a cumulative 1.65% over 5 years. In did not have preexisting lesion, significant CAS 1.3% at 12 months, 2.2% 24 2.5% 36 months post-radiotherapy. most important new age >65 years (aHR = 2.60, p 0.008, 95% confidence Interval: 1.28–5.30), laryngeal 2.36, p<0.017, 1.01–5.55), total plaque score 1.38, p<0.001, 1.23–1.56). There increase stenosis, score, wall thickness all areas (p<0.001). found be lower Thai population than other populations. years, cancer, score. Changes detected early affected artery. Patients treated by should assessed undergo vascular surveillance during

Language: Английский

Citations

0