Targeting the NLRP3 inflammasome in inflammatory diseases

Nature Reviews Drug Discovery, Journal Year: 2018, Volume and Issue: 17(8), P. 588 - 606

Published: July 20, 2018

Language: Английский

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DAMP-sensing receptors in sterile inflammation and inflammatory diseases

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 20(2), P. 95 - 112

Published: Sept. 26, 2019

Language: Английский

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Pyroptosis versus necroptosis: similarities, differences, and crosstalk

Cell Death and Differentiation, Journal Year: 2018, Volume and Issue: 26(1), P. 99 - 114

Published: Oct. 19, 2018

Language: Английский

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Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(3), P. 138 - 152

Published: Feb. 8, 2018

Language: Английский

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Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: April 22, 2022

Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing clinical trials have demonstrated that innate adaptive immune responses can promote or quell atherosclerosis. Several signaling pathways, are associated the response, been implicated within atherosclerosis such as NLRP3 inflammasome, toll-like receptors, proprotein convertase subtilisin/kexin type 9, Notch Wnt which of importance for development regression. Targeting especially inflammasome pathway its regulated cytokine interleukin-1β, could represent an attractive new route treatment atherosclerotic diseases. Herein, we summarize knowledge on cellular participants key pathways in atherosclerosis, discuss preclinical studies targeting these going to target some processes, effects quelling inflammation clinic.

Language: Английский

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Role of neuroinflammation in neurodegeneration development

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: July 12, 2023

Abstract Studies in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Amyotrophic lateral sclerosis, Huntington’s so on, have suggested that inflammation is not only a result of neurodegeneration but also crucial player this process. Protein aggregates which are very common pathological phenomenon can induce neuroinflammation further aggravates protein aggregation neurodegeneration. Actually, even happens earlier than aggregation. Neuroinflammation induced by genetic variations CNS cells or peripheral immune may deposition some susceptible population. Numerous signaling pathways range been to be involved the pathogenesis neurodegeneration, although they still far from being completely understood. Due limited success traditional treatment methods, blocking enhancing inflammatory considered promising strategies for therapy many them got exciting results animal models clinical trials. Some them, few, approved FDA usage. Here we comprehensively review factors affecting major pathogenicity sclerosis. We summarize current strategies, both clinic, diseases.

Language: Английский

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Extracellular ATP and P2 purinergic signalling in the tumour microenvironment

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(10), P. 601 - 618

Published: July 13, 2018

Language: Английский

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Role of pyroptosis in inflammation and cancer

Cellular and Molecular Immunology, Journal Year: 2022, Volume and Issue: 19(9), P. 971 - 992

Published: Aug. 15, 2022

Language: Английский

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Calcium signalling in T cells

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(3), P. 154 - 169

Published: Jan. 8, 2019

Language: Английский

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Targeting the NLRP3 Inflammasome in Severe COVID-19

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: June 23, 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus Betacoronavirus within family Coronaviridae. It an enveloped single-stranded positive-sense RNA virus. Since December 2019, global expansion infection has occurred with widespread dissemination disease 2019 (COVID-19). COVID-19 often manifests as only mild cold-like symptomatology, but severe complications occurs in 15% cases. Respiratory failure that can be accompanied by systemic inflammatory reaction characterized cytokine release. In cases, fatality caused rapid development lung injury characteristic distress (ARDS). Although ARDS complication SARS-CoV-2 infection, it not viral replication or causes tissue injury; rather, result dysregulated hyperinflammation response to infection. This pathology intense, stimulation innate immune triggers activation Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome pathway and release its products including proinflammatory cytokines IL-6 IL-1β. Here we review literature describes pathogenesis NLRP3 describe important role targeting this for treatment COVID-19.

Language: Английский

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