Chronic inflammation in the etiology of disease across the life span

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(12), P. 1822 - 1832

Published: Dec. 1, 2019

Language: Английский

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Cytokine Storm

New England Journal of Medicine, Journal Year: 2020, Volume and Issue: 383(23), P. 2255 - 2273

Published: Dec. 2, 2020

Common Terminology Criteria for Adverse

Language: Английский

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Pyroptosis: mechanisms and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: March 29, 2021

Abstract Currently, pyroptosis has received more and attention because of its association with innate immunity disease. The research scope expanded the discovery gasdermin family. A great deal evidence shows that can affect development tumors. relationship between tumors is diverse in different tissues genetic backgrounds. In this review, we provide basic knowledge pyroptosis, explain tumors, focus on significance tumor treatment. addition, further summarize possibility as a potential treatment strategy describe side effects radiotherapy chemotherapy caused by pyroptosis. brief, double-edged sword for rational use dual effect will help us explore formation ideas patients to develop new drugs based

Language: Английский

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NLRP3 inflammasome activation and cell death

Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 18(9), P. 2114 - 2127

Published: July 28, 2021

Language: Английский

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

European Journal of Immunology, Journal Year: 2019, Volume and Issue: 49(10), P. 1457 - 1973

Published: Oct. 1, 2019

These guidelines are a consensus work of considerable number members the immunology and flow cytometry community. They provide theory key practical aspects enabling immunologists to avoid common errors that often undermine immunological data. Notably, there comprehensive sections all major immune cell types with helpful Tables detailing phenotypes in murine human cells. The latest techniques applications also described, featuring examples data can be generated and, importantly, how analysed. Furthermore, tips, tricks pitfalls avoid, written peer-reviewed by leading experts field, making this an essential research companion.

Language: Английский

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<p>Reactive Oxygen Species: Drivers of Physiological and Pathological Processes</p>

Journal of Inflammation Research, Journal Year: 2020, Volume and Issue: Volume 13, P. 1057 - 1073

Published: Dec. 1, 2020

Abstract: Since the Great Oxidation Event, about 2.4 billion years ago, Earth is immersed in an oxidizing atmosphere. Thus, it has been proposed that excess oxygen, originally a waste product of photosynthetic cyanobacteria, induced oxidative stress and production reactive oxygen species (ROS), which have since acted as fundamental drivers biologic evolution eukaryogenesis. Indeed, throughout organism's lifespan, ROS affect directly (as mutagens) or indirectly messengers regulators) all structural functional components cells, many aspects cell biology. Whether left unchecked by protective antioxidant systems, not only cause genomic mutations but also induce irreversible modification proteins (protein oxidation peroxidation), lipids glycans (advanced lipoxidation glycation end products), impairing their function promoting disease death. Conversely, low-level local play important role both redox-signaling molecules wide spectrum pathways involved maintenance cellular homeostasis (MAPK/ERK, PTK/PTP, PI3K-AKT-mTOR), regulating key transcription factors (NFκB/IκB, Nrf2/KEAP1, AP-1, p53, HIF-1). Consequently, can shape variety functions, including proliferation, differentiation, migration apoptosis. In this review, we will give brief overview relevance physiological pathological processes, particularly inflammation aging. In-depth knowledge molecular mechanisms actuation influence under steady-state stressful conditions pave way for development novel therapeutic interventions. This mitigate harmful outcomes onset progression chronic inflammatory age-related diseases. Keywords: species, stress,

Language: Английский

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Role of pyroptosis in inflammation and cancer

Cellular and Molecular Immunology, Journal Year: 2022, Volume and Issue: 19(9), P. 971 - 992

Published: Aug. 15, 2022

Language: Английский

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Necroptosis: a crucial pathogenic mediator of human disease

JCI Insight, Journal Year: 2019, Volume and Issue: 4(15)

Published: Aug. 7, 2019

Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an important pathway in human disease. The necroptosis induced by variety signals, including receptor ligands, and receptor-interacting protein kinases 1 3 (RIPK1 RIPK3) mixed-lineage kinase domain–like pseudokinase (MLKL), which regulatory necrosome complex. RIPK3-mediated phosphorylation MLKL executes necroptosis. Recent studies, using animal models tissue injury, have revealed RIPK3 are key effectors injury propagation. This Review explores the functional roles crucial pathogenic determinants markers disease progression severity experimental disease, acute chronic pulmonary diseases; renal, hepatic, cardiovascular, neurodegenerative cancer; critical illness.

Language: Английский

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Cell death due to electroporation – A review

Bioelectrochemistry, Journal Year: 2021, Volume and Issue: 141, P. 107871 - 107871

Published: June 5, 2021

Exposure of cells to high voltage electric pulses increases transiently membrane permeability through electroporation. Electroporation can be reversible and is used in gene transfer enhanced drug delivery but also lead cell death. resulting death (termed as irreversible electroporation) has been successfully a new non-thermal ablation method soft tissue such tumours or arrhythmogenic heart tissue. Even though the mechanisms influence outcome electroporation-based treatments due use different pulse parameters conditions, these are not elucidated yet. We review after electroporation reported literature, injuries that may repair involved. The knowledge exposure pulses, targets field need identified optimize existing develop techniques medicine, biotechnology, food technology.

Language: Английский

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A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer

Cell Death Discovery, Journal Year: 2021, Volume and Issue: 7(1)

Published: April 7, 2021

Abstract Ovarian cancer (OC) is a highly malignant gynaecological tumour that has very poor prognosis. Pyroptosis been demonstrated in recent years to be an inflammatory form of programmed cell death. However, the expression pyroptosis-related genes OC and their correlations with prognosis remain unclear. In this study, we identified 31 pyroptosis regulators were differentially expressed between normal ovarian tissues. Based on these (DEGs), all cases could divided into two subtypes. The prognostic value each gene for survival was evaluated construct multigene signature using Cancer Genome Atlas (TCGA) cohort. By applying least absolute shrinkage selection operator (LASSO) Cox regression method, 7-gene built classified patients TCGA cohort low- or high-risk group. low-risk group showed significantly higher possibilities than those ( P < 0.001). Utilizing median risk score from cohort, Gene Expression Omnibus (GEO) subgroups, had increased overall (OS) time = 0.014). Combined clinical characteristics, found independent factor predicting OS patients. ontology (GO) Kyoto Encylopedia Genes Genomes (KEGG) analyses indicated immune-related enriched immune status decreased conclusion, play important roles immunity can used predict OCs.

Language: Английский

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