Eco-friendly synthesis of Chitosan NPs from Fioria vitifolia (L.) L: Potential to Antibacterial, Antioxidant, Cytotoxicity properties of HepG2 cells and their evaluation of safety on Zebrafish embryo

Results in Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 104076 - 104076

Published: Jan. 1, 2025

Language: Английский

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Novel pH-responsive hybrid hydrogels for controlled delivery of curcumin: Overcoming conventional constraints and enhancing cytotoxicity in MCF-7 cells

Hybrid Advances, Journal Year: 2024, Volume and Issue: 6, P. 100210 - 100210

Published: May 1, 2024

Traditional drug delivery techniques often have drawbacks such inadequate bioavailability, quick clearance, and non-specific targeting, which may result in unfavorable side effects. Hybrid nanocarriers composed of nanoclay the potential to be a viable solution these problems. The goal this work was design biocompatible hybrid nanocarrier that would release curcumin under regulated conditions specific locations, especially cancer cells. FTIR, XRD, FESEM were used effectively construct evaluate our polyvinyl pyrrolidone/polyethylene glycol/montmorillonite (PVP/PEG/MMT) hydrogels, verifying their synthesis intended features. Zeta DLS studies showed suitable size distribution (∼300 nm) high stability. encapsulation efficiency profile assessed using use UV spectrophotometry dialysis bag technique. findings gradual continuous highly impacted by acidic environment (which mimicked characteristics cells), suggesting pH-responsive activity. MTT test vitro cytotoxicity experiments show curcumin-loaded more effective against MCF-7 cells than solution. Increased rates necrosis apoptosis treated with formulation further validated flowcytometry. According results, PVP/PEG/MMT hydrogels lot as cutting-edge strategy for curcumin. They able overcome some traditional improve effectiveness treatment

Language: Английский

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Polymeric and non-polymeric oxaliplatin nanomedicine for cancer therapy: A comprehensive review

European Polymer Journal, Journal Year: 2024, Volume and Issue: 208, P. 112870 - 112870

Published: Feb. 23, 2024

Language: Английский

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Fioria vitifolia-mediated silver nanoparticles: Eco-friendly synthesis and biomedical potential

Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 66, P. 106020 - 106020

Published: Aug. 23, 2024

Language: Английский

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A comprehensive perspective of trastuzumab-based delivery systems for breast cancer treatment

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105592 - 105592

Published: March 16, 2024

Language: Английский

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Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 701 - 701

Published: Feb. 19, 2025

Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects

Language: Английский

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Chitosan-Coated Silver Nanourchins for Imatinib Mesylate Delivery: Biophysical Characterization, In-Silico Profiling, and Anti-Colon Cancer Efficacy

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

This study investigates the synthesis and characterization of silver nanourchins coated with chitosan (IMT-CS-AgNUs) as a novel platform for delivery imatinib mesylate (IMT) treatment colon cancer. In-silico analysis discovered 10 key metabolites IMT, which have associated respiratory neurotoxic risks. Molecular docking studies showed high affinity binding IMT to critical proteins, including BCL2 (−6.637 kcal/mol), Caspase-6, EGFR, proved its potential therapeutic value. IMT-CS-AgNUs were prepared by ionic gelation, nanoparticles had size 192.98 nm, an entrapment efficiency 85.7%. The FTIR XRD structural confirmed that nanocarriers stable amorphous in nature. In vitro HCT116 cells significantly increased cytotoxicity IC50 0.4 μg/mL; apoptosis 42.5% ROS generation 47.8% when compared only IMT. release drugs from was sustained over 85% 60 h, selectively inhibited pathogenic bacteria without harming beneficial microbes, antiangiogenic activity, is validated through HET-CAM assay. Gene expression analyses there marked downregulation upregulation apoptotic genes. Pharmacokinetic Wistar rats improved bioavailability 1.8, allows targeted drug concentrations lessened systemic toxicity. Thus, development represents potent approach therapy against cancer, providing efficacy, controlled release, added safety.

Language: Английский

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Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 194 - 194

Published: March 8, 2025

Propolis has been well known for centuries as a natural preventive and therapeutic agent. Its numerous health benefits are mainly attributed to its high content of phenolic compounds that have remarkable antioxidant activity. Since phenolics may exert dual nature (pro-oxidant antioxidant) the aim this study was investigate safety profile ethanolic extract propolis related flavonoid galangin their ability protect lymphocytes from irinotecan-induced cyto/genotoxicity in vitro. Isolated human peripheral blood were exposed 3 h three concentrations corresponding average daily dose 0.25 mL [propolis 70% ethanol (3:7, w/w)], five- ten-fold higher concentration. Cyto- genoprotective effects tested using cytokinesis-block micronucleus cytome assay. Treatment with selected exerted biocompatibility diminished level cytogenetic damage caused by irinotecan. at same concentration offered stronger protective effect than single galangin. Also, apoptosis prevailing mechanism cell death our experimental conditions. These preliminary results speak favour future investigations other available methods models.

Language: Английский

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Construction of Redox-Responsive PEG Cloaked Mesoporous Silica Core-Shell Nanoparticles: Examination of Prostate Cancer Cells Proliferation and Apoptosis Induction

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

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Uptake of Self-Assembling Amphiphilic Tryptophan-Based Polymer Nanoparticles in Three-Dimensional Cell Culture Models

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(17), P. 21181 - 21190

Published: Sept. 4, 2024

Language: Английский

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