Cell Calcium, Journal Year: 2023, Volume and Issue: 113, P. 102762 - 102762
Published: May 20, 2023
Language: Английский
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: Sept. 21, 2024
are common members of the human gut microbiota. Multiple reports have emerged linking abundance
Language: Английский
Citations
7
Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)
Published: Sept. 24, 2022
Abstract Akkermansia muciniphila ( A. ) is present in the human gut microbiota from infancy and gradually increases adulthood. The potential impact of abundance has been studied major cardiovascular diseases including elevated blood pressure or hypertension (HTN). HTN a factor premature death worldwide, approximately 1.28 billion adults aged 30–79 years have hypertension. being considered next-generation probiotic though numerous studies had highlighted positive role lowering/controlling HTN, however, few negative increased management HTN. Thus, review, we aimed to discuss current facts, evidence, controversy about A . pathophysiology its effect on management/regulation, which could be beneficial identifying drug target for
Language: Английский
Citations
28
Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14
Published: July 28, 2022
Aging is the biggest risk factor for developing Parkinson's disease (PD), second most common neurodegenerative disorder. Several animal models have been developed to explore pathophysiology underlying neurodegeneration and initiation spread of alpha-synuclein-related PD pathology, investigate biomarkers therapeutic strategies. However, bench-to-bedside translation preclinical findings remains suboptimal successful disease-modifying treatments remain be discovered. Despite aging being main idiopathic PD, studies employ young animals in their experimental set-up, hereby ignoring age-related cellular molecular mechanisms at play. Consequently, may not an accurate reflection human limiting translational outcomes. Recently, it has shown that aged research demonstrate a higher susceptibility pathology neurodegeneration, present with more disseminated accelerated course, compared animals. Here we review recent advances investigation role research, including challenges related are widespread use. Overall, current indicate use required account interactions pathophysiology. Thus, although older disadvantages, model better represents clinical within elderly would beneficial long run, as will increase value minimize therapies failing during studies. Furthermore, provide recommendations manage models.
Language: Английский
Citations
26
Nutrients, Journal Year: 2022, Volume and Issue: 14(19), P. 3967 - 3967
Published: Sept. 24, 2022
Herein we gathered updated knowledge regarding the alterations of gut microbiota (dysbiosis) and its correlation with human neurodegenerative brain-related diseases, e.g., Alzheimer’s Parkinson’s. This review underlines importance gut-derived metabolites metabolic status as main players in gut-brain crosstalk their implications on severity neural conditions. Scientific evidence indicates that administration probiotic bacteria exerts beneficial protective effects reduced systemic inflammation, neuroinflammation, inhibited neurodegeneration. The experimental results performed animals, but also clinical trials, show designing a novel microbiota-based dietary supplementation aim to prevent or ease symptoms Parkinson’s diseases other forms dementia
Language: Английский
Citations
23
Cells, Journal Year: 2023, Volume and Issue: 12(9), P. 1237 - 1237
Published: April 25, 2023
Although previously restricted to a limited number of medical conditions, there is growing appreciation that 'autoimmune' (or immune-mediated) processes are important aspects wide array diverse including cancers, neurodegenerative diseases and psychiatric disorders. All these classes conditions associated with alterations in mitochondrial function across an cell types. Accumulating data indicate the presence melatonergic pathway possibly all body cells, consequences for pathways crucial driving CD8+ T B-cell 'autoimmune'-linked processes. Melatonin suppression coupled upregulation oxidative stress suppress PTEN-induced kinase 1 (PINK1)/parkin-driven mitophagy, raising levels major histocompatibility complex (MHC)-1, which underpins chemoattraction cells activation antibody-producing B-cells. Many factors closely autoimmunity, gut microbiome/permeability, circadian rhythms, aging, aryl hydrocarbon receptor, brain-derived neurotrophic factor (BDNF) its receptor tyrosine B (TrkB) interact pathway. A future research directions novel treatment implications indicated this collection poorly conceptualized treated presentations. It proposed etiology many 'autoimmune'/'immune-mediated' disorders should be as significantly determined by dysregulation, being aspect pathoetiologies.
Language: Английский
Citations
14
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 201, P. 106655 - 106655
Published: Aug. 30, 2024
This study aims to identify distinct microbial and functional biomarkers characteristic of body-first or brain-first subtypes Parkinson's disease (PD). could illuminate the unique pathogenic mechanisms within these subtypes.
Language: Английский
Citations
5
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 122 - 122
Published: Jan. 7, 2025
The role of α-synuclein (α-syn) pathology in Parkinson's disease (PD) is well established; however, effective therapies remain elusive. Two mechanisms central to PD neurodegeneration are the intracellular aggregation misfolded α-syn and uptake aggregates into neurons. Cationic arginine-rich peptides (CARPs) an emerging class molecule with multiple neuroprotective action, including protein stabilisation. This study characterised both cortical neurons vitro. Thereafter, this examined therapeutic potential CARP, R18D (18-mer D-arginine), prevent aforementioned pathogenic processes through a cell-free thioflavin-T (ThT) assay To induce aggregation, rat primary were exposed seed (0.14 μM) for 2 h allow protein, followed by treatment (0.0625, 0.125, 0.25, 0.5 μM), subsequent measurement 48 later using homogenous time-resolved fluorescence (HTRF) assay. assess neuronal uptake, seeds covalently labelled Alexa-Fluor 488 fluorescent tag, pre-incubated (0.125, then 24 assessed via confocal microscopy. It was demonstrated that significantly reduced 37.8% 77.7%, respectively. Also, monomers These findings highlight inhibit key pathological progression.
Language: Английский
Citations
0
Movement Disorders Clinical Practice, Journal Year: 2025, Volume and Issue: unknown
Published: March 13, 2025
Abstract Background The gut‐brain axis, i.e. the bidirectional communication system between gut and brain, has become of central importance in Parkinson disease (PD) research over past 20 years. Aims We aimed to describe milestones axis PD development theories proposing involvement gastrointestinal tract pathogenesis. Methods searched PubMed using terms ‘gut‐brain axis’ AND ‘Parkinson disease’, selected relevant articles provide foundation for reconstructing an historical overview PD. Results Mounting evidence from preclinical, clinical post‐mortem studies suggests that a subgroup patients present with range prodromal symptoms (e.g., autonomic dysfunction, rapid eye movement sleep behaviour disorder) which reflect initial accumulation later spread pathological α‐synuclein rostrally (“body‐first” PD). Through neural connections along may producing clinically manifest disease. Recently, two mechanisms involving have attracted increasing attention their role pathogenesis progression, namely perturbation composition microorganisms living (the microbiome), dysfunction enteroendocrine cells. Conclusion Treatments targeting especially microbiome cells pathway, could potentially slow progression or even prevent onset. Among these, pre/probiotics, faecal microbiota transplantation, glucagon‐like peptide‐1 receptor agonists, entered advanced stages trials humans shown potential symptomatic disease‐modifying effects.
Language: Английский
Citations
0
Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)
Published: March 27, 2025
Microglia and astrocytes are the primary glial cells in central nervous system (CNS) their function is shaped by multiple factors. Regulation of CNS glia microbiota have been reported, although role specific bacteria has not identified. We colonized germ-free mice with type strain Akkermansia muciniphila (AmT) a novel A. BWH-H3 (Am-H3) isolated from subject sclerosis compared to Bacteroides cellulosilyticus BWH-E5 (Bc) healthy control subject. then investigated effect these on microglia astrocyte gene expression RNA sequencing. found altered profiles brain microglia, downregulating genes related antigen presentation cell migration. Furthermore, we observed effects, H3 upregulating histone protein binding associated channel ion transport genes. Astrocyte pathways that were mono-colonization included upregulation proliferation downregulation cytoskeletal animals had effects immune including elevated splenic γδ-T increased IFNγ production CD4 + T cells. also measured intestinal short chain fatty acids both strains produced proprionate while B. acetate, proprionate, isovalerate. Taken together, our study shows members influence microglial astroyctes which may be mediated changes peripheral signaling.
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 396(11), P. 2911 - 2923
Published: June 7, 2023
Language: Английский
Citations
10