Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Nov. 17, 2023
Dengue
virus
(DENV)
infection
remains
a
challenging
health
threat
worldwide.
Ubiquitin-specific
protease
18
(USP18),
which
preserves
the
anti-interferon
(IFN)
effect,
is
an
ideal
target
through
DENV
mediates
its
own
immune
evasion.
However,
much
of
function
and
mechanism
USP18
in
regulating
replication
incompletely
understood.
In
addition,
whether
regulates
merely
by
causing
IFN
hyporesponsiveness
not
clear.
present
study,
using
several
different
approaches
to
block
signaling,
including
neutralizing
antibodies
(Abs),
anti-IFN
receptor
Abs,
Janus
kinase
inhibitors
alpha
beta
subunit
1
(IFNAR1)knockout
cells,
we
showed
that
may
regulate
IFN-associated
IFN-unassociated
manners.
Localized
mitochondria,
regulated
release
mitochondrial
DNA
(mtDNA)
cytosol
affect
viral
replication,
mechanisms
such
as
reactive
oxygen
species
(mtROS)
production,
changes
membrane
potential,
mobilization
calcium
into
8-oxoguanine
glycosylase
(OGG1)
expression,
oxidation
fragmentation
mtDNA,
opening
permeability
transition
pore
(mPTP)
were
involved
USP18-regulated
mtDNA
cytosol.
We
therefore
identify
machineries
are
association
with
effects.
BJU International,
Journal Year:
2024,
Volume and Issue:
134(5), P. 696 - 713
Published: July 5, 2024
The
mitochondrion
serves
as
a
critical
intracellular
organelle,
engaging
in
essential
roles
the
regulation
of
energy
production,
oxidative
stress
management,
calcium
homeostasis,
and
apoptosis.
One
such
disease
that
has
been
particularly
associated
with
these
functions
is
kidney
stone
(KSD),
specifically
oxalate
(CaOx).
It
underpinned
by
tissue
inflammation.
Recent
studies
have
shed
light
on
vital
involvement
mitochondrial
dysfunction,
nucleotide-binding
domain
leucine-rich
repeat
containing
protein
3
(NLRP3)
inflammasome,
endoplasmic
reticulum
subsequent
cell
death
CaOx
crystal
retention
aggregation.
These
processes
are
pivotal
pathogenesis
formation.
This
review
focuses
mitochondria
renal
provides
an
overview
intricate
interconnectedness
between
dysfunction
NLRP3
inflammasome
activation
context
KSD.
to
recognise
utmost
significance
gaining
comprehensive
understanding
mechanisms
safeguard
function
regulate
inflammasome.
Such
knowledge
carries
significant
scientific
implications
opens
up
promising
avenues
for
development
innovative
strategies
prevent
formation
stones.
Gene Expression,
Journal Year:
2023,
Volume and Issue:
22(4), P. 329 - 344
Published: Nov. 30, 2023
Inflammation
is
a
natural
reaction
of
the
innate
immune
system
that
evolved
primarily
to
protect
human
body
from
invading
pathogens
and
heal
injuries.
There
are
two
different
types
inflammation,
acute
chronic
differing
in
duration,
underlying
causes,
characteristics.
The
acute-to-chronic
transition
can
be
determined
by
several
pathomechanisms,
including
dysregulation
response
failure
eliminate
cause.
Moreover,
epigenetic
changes
refer
modifications
gene
expression
heritable
but
do
not
involve
DNA
sequence
also
contribute
prolonged
inflammation.
Emerging
evidence
suggests
dysfunctional
mitochondria
promote
development
In
this
respect,
mechanisms
triggering
defective
mitophagy,
selective
form
autophagy
exterminates
maintain
cellular
homeostasis,
attracted
special
attention.
hypothesis
on
pivotal
role
mutations
mitochondrial
causing
mitophagy
stimulated
area
research
applies
editing
genome.
mitoCAS9
vector
single
guide
RNAs
G15059A
mutation
were
used
macrophage-like
cells.
normal
activity
initially
was
restored
intact
cells,
confirming
causal
disruption
process.
unraveling
inflammation
will
help
develop
targeted
therapeutic
approaches
aimed
at
restoring
health
alleviating
for
treatment
wide
range
inflammatory
diseases.
PLoS Pathogens,
Journal Year:
2024,
Volume and Issue:
20(8), P. e1012387 - e1012387
Published: Aug. 30, 2024
Infection
of
Rift
Valley
fever
virus
(RVFV),
a
highly
pathogenic
mosquito-borne
zoonotic
virus,
triggers
severe
inflammatory
pathogenesis
but
the
underlying
mechanism
inflammation
activation
is
currently
unclear.
Here,
we
report
that
non-structural
protein
NSs
RVFV
mitochondrial
damage
to
activate
NLRP3
inflammasome
leading
viral
in
vivo.
It
found
host
transcription
inhibition
effect
causes
rapid
down-regulation
myeloid
cell
leukemia-1(MCL-1),
pro-survival
member
Bcl-2
(B-cell
lymphoma
2)
family.
MCL-1
led
BAK
mitochondria,
which
triggered
mtROS
production
and
release
oxidized
DNA
(ox-mtDNA)
into
cytosol.
Cytosolic
ox-mtDNA
binds
activates
triggering
NLRP3-GSDMD
pyroptosis
infected
cells.
A
mutant
(RVFV-NSsRM)
compromised
inducing
did
not
trigger
nor
pyroptosis.
infection
Nlrp3-/-
mouse
model
demonstrated
RVFV-triggered
contributed
fatal
with
RVFV-NSsRM
similarly
showed
alleviated
reduced
fatality
rate.
Taken
together,
these
results
revealed
by
virulence
factor
MCL-1-BAK
axis
through
NLRP3-dependent
pathogenesis.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Nov. 17, 2023
Dengue
virus
(DENV)
infection
remains
a
challenging
health
threat
worldwide.
Ubiquitin-specific
protease
18
(USP18),
which
preserves
the
anti-interferon
(IFN)
effect,
is
an
ideal
target
through
DENV
mediates
its
own
immune
evasion.
However,
much
of
function
and
mechanism
USP18
in
regulating
replication
incompletely
understood.
In
addition,
whether
regulates
merely
by
causing
IFN
hyporesponsiveness
not
clear.
present
study,
using
several
different
approaches
to
block
signaling,
including
neutralizing
antibodies
(Abs),
anti-IFN
receptor
Abs,
Janus
kinase
inhibitors
alpha
beta
subunit
1
(IFNAR1)knockout
cells,
we
showed
that
may
regulate
IFN-associated
IFN-unassociated
manners.
Localized
mitochondria,
regulated
release
mitochondrial
DNA
(mtDNA)
cytosol
affect
viral
replication,
mechanisms
such
as
reactive
oxygen
species
(mtROS)
production,
changes
membrane
potential,
mobilization
calcium
into
8-oxoguanine
glycosylase
(OGG1)
expression,
oxidation
fragmentation
mtDNA,
opening
permeability
transition
pore
(mPTP)
were
involved
USP18-regulated
mtDNA
cytosol.
We
therefore
identify
machineries
are
association
with
effects.
