Topical treatments for skin cancer

Advanced Drug Delivery Reviews, Journal Year: 2019, Volume and Issue: 153, P. 54 - 64

Published: Nov. 6, 2019

Language: Английский

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3D wide‐field multispectral photoacoustic imaging of human melanomas in vivo: a pilot study

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2020, Volume and Issue: 35(3), P. 669 - 676

Published: Oct. 10, 2020

Abstract Background The Breslow depth is an important parameter to determine the excision margin and prognosis of melanoma. However, it difficult accurately actual before surgery using existing ocular micrometer biopsy technique. Objectives To evaluate use 3D wide‐field multispectral photoacoustic imaging non‐invasively measure outline boundary melanomas for optimal surgical selection. Methods Six melanoma patients were examined in vivo system. For five cases (one situ , three nodular, one acral lentiginous type melanoma), spectrally unmixed depths calculated compared against histopathological depths. Results Spectrally match well within a mean absolute error 0.36 mm. In particular, measured minimum maximum nodular 0.6 9.1 mm, respectively. image metastatic melanoma, feeding vessels visualized suggesting neovascularization around tumour. Conclusions not only provides well‐measured sizes various types melanomas, also visualizes Obtaining accurate information would play useful role complete during surgery.

Language: Английский

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The State of Melanoma: Emergent Challenges and Opportunities

Clinical Cancer Research, Journal Year: 2021, Volume and Issue: 27(10), P. 2678 - 2697

Published: Jan. 7, 2021

Five years ago, the Melanoma Research Foundation (MRF) conducted an assessment of challenges and opportunities facing melanoma research community patients with melanoma. Since then, remarkable progress has been made on both basic clinical fronts. However, incidence, recurrence, death rates for remain unacceptably high significant remain. Hence, MRF Scientific Advisory Council Breakthrough Consortium, a group that includes clinicians scientists, reconvened to facilitate intensive discussions thematic areas essential researchers alike, prevention, detection, diagnosis, metastatic dormancy progression, response resistance targeted immune-based therapy, consequences COVID-19 providers. These extensive helped crystalize our understanding broader today. In this report, we discuss since last assessment, comment what remains be overcome, offer recommendations best path forward.

Language: Английский

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Prognostic Gene Expression Profiling in Cutaneous Melanoma

JAMA Dermatology, Journal Year: 2020, Volume and Issue: 156(9), P. 1004 - 1004

Published: July 29, 2020

Importance

Use of prognostic gene expression profile (GEP) testing in cutaneous melanoma (CM) is rising despite a lack endorsement as standard care.

Objective

To develop guidelines within the national Melanoma Prevention Working Group (MPWG) on integration GEP into management patients with CM, including (1) review published data using tests, (2) definition acceptable performance criteria, (3) current recommendations for use clinical practice, and (4) considerations future studies.

Evidence Review

The MPWG members other international specialists participated 2 online surveys then convened summit meeting. Published meeting abstracts from 2015 to 2019 were reviewed.

Findings

are optimistic about improve risk stratification enhance decision-making but acknowledge that utility limited by test stage I disease. studies have not evaluated results context all relevant clinicopathologic factors or predictors regional nodal metastasis replace sentinel lymph node biopsy (SLNB). tests has generally been reported small groups representing particular tumor stages aggregate form, such stage-specific cannot be ascertained, without survival outcomes compared American Joint Committee Cancer 8th edition staging system database. There significant challenges performing trials incorporating SLNB adjuvant therapy. favor conducting retrospective evaluate multiple platforms fully annotated archived samples before embarking costly prospective recommend avoiding routine direct patient until support their utility.

Conclusions Relevance

More evidence needed inform regarding SLNB, intensity follow-up imaging surveillance, postoperative recommends further research assess validity applicability existing emerging tests. Decisions based these should only made discussion limitations multidisciplinary group.

Language: Английский

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Skin cancer: Primary, secondary, and tertiary prevention. Part II.

Journal of the American Academy of Dermatology, Journal Year: 2022, Volume and Issue: 87(2), P. 271 - 288

Published: Feb. 14, 2022

Language: Английский

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Melanoma classification and management in the era of molecular medicine

Dermatologic Clinics, Journal Year: 2022, Volume and Issue: 41(1), P. 49 - 63

Published: Oct. 28, 2022

Language: Английский

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Risk of Mortality After a Diagnosis of Melanoma In Situ

JAMA Dermatology, Journal Year: 2023, Volume and Issue: 159(7), P. 703 - 703

Published: June 7, 2023

Importance The incidence of melanoma in situ (MIS) is increasing more rapidly than any invasive or cancer the US. Although half melanomas diagnosed are MIS, information about long-term prognosis following a diagnosis MIS remains unknown. Objective To evaluate mortality and factors associated with after MIS. Design, Setting, Participants This population-based cohort study adults first primary from 2000 to 2018 included data US Surveillance, Epidemiology, End Results Program, which were analyzed July September 2022. Main Outcomes Measures Mortality was evaluated using 15-year melanoma-specific survival, relative survival (ie, compared similar individuals without MIS), standardized ratios (SMRs). Cox regression used estimate hazard (HRs) for death by demographic clinical characteristics. Among 137 872 patients first-and-only mean (SD) age at 61.9 (16.5) years (64 027 women [46.4%]; 239 [0.2%] American Indian Alaska Native, 606 [0.4%] Asian, 344 Black, 3348 [2.4%] Hispanic, 133 335 [96.7%] White individuals). Mean (range) follow-up 6.6 (0-18.9) years. 98.4% (95% CI, 98.3%-98.5%), whereas 112.4% 112.0%-112.8%). SMR 1.89 1.77-2.02); however, all-cause 0.68 0.67-0.7). Risk higher older (7.4% those 80 vs 1.4% aged 60-69 years; adjusted HR, 8.2; 95% 6.7-10.0) acral lentiginous histology results (3.3% 0.9% superficial spreading; 5.3; 2.3-12.3). Of 6751 (4.3%) experienced second 11 628 (7.4%) Compared subsequent melanoma, risk increased (adjusted 4.1; 3.6-4.6) decreased 0.7; 0.6-0.9). Conclusions relevance this suggest that have an but low live longer people general population, suggesting there significant detection low-risk disease among health-seeking individuals. Factors include (≥80 years) melanoma.

Language: Английский

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Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 470 - 485

Published: Feb. 2, 2024

Language: Английский

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Photoacoustic imaging for cutaneous melanoma assessment: a comprehensive review

Journal of Biomedical Optics, Journal Year: 2024, Volume and Issue: 29(S1)

Published: Jan. 12, 2024

SignificanceCutaneous melanoma (CM) has a high morbidity and mortality rate, but it can be cured if the primary lesion is detected treated at an early stage. Imaging techniques such as photoacoustic (PA) imaging (PAI) have been studied implemented to aid in detection diagnosis of CM.AimProvide overview different PAI systems applications for study CM, including determination tumor depth/thickness, cancer-related angiogenesis, metastases lymph nodes, circulating cells (CTCs), virtual histology, studies using exogenous contrast agents.ApproachA systematic review classification configurations was conducted based on their specific detection. This encompasses animal preclinical studies, offering insights into future potential clinic.ResultsPAI holds great clinical noninvasive technique disease management. PA microscopy predominantly used image angiogenesis surrounding tumors provide information characteristics. Additionally, tomography, with its increased penetration depth, demonstrated ability assess thickness. Both modalities shown promise detecting nodes CTCs, all-optical implementation developed perform histology analyses. Animal human successfully capability detect, visualize, classify, stage CM.ConclusionsPAI promising assessing status skin without surgical procedure. The modality microvasculature, visualize boundaries, detect fast label-free identify CTCs could metastatic status. In addition, useful monitoring treatment efficacy noninvasively.

Language: Английский

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The Use of Gene Expression Profiling and Biomarkers in Melanoma Diagnosis and Predicting Recurrence: Implications for Surveillance and Treatment

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 583 - 583

Published: Jan. 30, 2024

Cutaneous melanoma is becoming more prevalent in the United States and has highest mortality among cutaneous malignancies. The majority of melanomas are diagnosed at an early stage and, as such, survival generally favorable. However, there remains prognostic uncertainty subsets early- intermediate-stage patients, some whom go on to develop advanced disease while others remain disease-free. Melanoma gene expression profiling (GEP) evolved with notion help bridge this gap identify higher- or lower-risk patients better tailor treatment surveillance protocols. These tests seek prognosticate independently established AJCC 8 cancer staging clinicopathologic features (sex, age, primary tumor location, thickness, ulceration, mitotic rate, lymphovascular invasion, microsatellites, and/or SLNB status). While a significant opportunity improve accuracy prognostication diagnosis, it equally important understand current landscape molecular for treatment. Society guidelines currently do not recommend testing outside clinical trials decision making, citing insufficient high-quality evidence guiding indications interpretation results. goal chapter review available literature GEP diagnosis their place paradigms.

Language: Английский

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