Addressing the unmet needs of patients with BRAF-mutated melanoma in Latin America: Expert perspective DOI Creative Commons
Pamela Salman, Andréia Cristina de Melo, Mariana Rico-Restrepo

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: March 14, 2023

Melanoma represents an increasing public health burden with extensive unmet needs in Latin America (LA). A mutation the BRAF gene is present approximately 50% of all melanomas White populations and a target precision medicine, potential to dramatically improve patient outcomes. Thus, increased access testing therapy LA must be explored. At multi-day conference, panel American experts oncology dermatology were provided questions address barriers limiting for patients melanoma LA, who may eligible targeted their prognosis. During responses discussed edited until consensus on addressing was achieved. Identified challenges included ignorance -status implications, limited human infrastructural resources, affordability reimbursement, fragmented care delivery, pitfalls sample journey, lack local data. Despite clear benefits therapies -mutated other regions, there no path prepare sustainable personalized medicine approach this disease. Due melanoma’s time-sensitive nature, aim provide early consider mutational status within treatment decision making. To end, recommendations are include establishing multidisciplinary teams referral centers improving diagnosis treatment.

Language: Английский

Squamous-Cell Carcinoma of the Skin DOI
Ashley Wysong

New England Journal of Medicine, Journal Year: 2023, Volume and Issue: 388(24), P. 2262 - 2273

Published: June 14, 2023

Squamous-cell carcinoma is one of the most common cancers in humans. Most cases are localized and treatable; small percentage that recur or spread can be fatal. Immunocompromised patients at especially high risk.

Language: Английский

Citations

30
Integrated Copper Nanomaterials‐Decorated Microsphere Photothermal Platform for Comprehensive Melanoma Treatment DOI Creative Commons
Xinyi Zhang, Mengya Zhang,

Hengqing Cui

et al.

Small Structures, Journal Year: 2024, Volume and Issue: 5(6)

Published: April 1, 2024

Patients who undergo resection for melanoma face challenges, such as delayed healing and radiation dermatitis. Moreover, incomplete tumor is a key factor contributing to poor prognosis increased recurrence rates. However, therapeutic platform that can effectively prevent promote wound remains challenge. Hence, pioneering approach presented using melanoma‐derived cancer cell membrane (CM) antigen encapsulate copper (Cu)‐based metal‐organic framework (MOF) nanomaterials fabricate termed MOF@CM. Then MOF@CM adsorbed onto polydopamine (PDA)‐modified poly lactic‐co‐glycolic acid (PLGA) porous microspheres (PLGA/PDA) develop the nanomaterials‐decorated PLGA/PDA‐CCM (PLGA/PDA loaded with CM‐coated MOF). It exerts homologous targeting photothermal effects, inducing immunogenic death. Simultaneously, sustained release of shows enhanced presentation in dendritic cells (DCs) help CpG, induces DC maturation activated immune responses, acting an effective vaccine recurrence. The harnesses combined advantages local thermal effect presence Cu‐based MOF, which endow antibacterial properties stimulate angiogenesis, thereby facilitating mitigating This integrated microsphere treatment represents promising strategy addressing melanoma.

Language: Английский

Citations

12
Photodynamic Therapy in Cancer: Insights into Cellular and Molecular Pathways DOI Creative Commons

Vincenzo Papa,

Fabiana Furci, Paola Lucia Minciullo

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 69 - 69

Published: Jan. 21, 2025

Photodynamic therapy is a non-ionizing radiation treatment that utilizes photosensitizer in combination with light to produce singlet oxygen. This oxygen induces anti-cancer effects by causing apoptotic, necrotic, or autophagic cell death tumor cells. Currently, photodynamic employed oncology treat various cancers. In the presence of oxygen, this non-invasive approach leads direct death, damage microvasculature, and induction local inflammatory response. These allow be effective treating early-stage tumors, extending survival cases where surgery not feasible, significantly improving quality life. paper, we provide state art on cytomolecular mechanisms associated pathways involved therapy. By integrating these mechanistic insights most recent advancements nanotechnology, phototherapeutic has potential become prevalent option within conventional cancer therapies, enhancing its application precision medicine.

Language: Английский

Citations

1
Cutaneous melanoma in older patients DOI Creative Commons
Alessandra Buja, Massimo Rugge, Chiara Trevisiol

et al.

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 6, 2024

Abstract Background In industrialized countries, the aging population is steadily rising. The incidence of cutaneous malignant melanoma (CMM) highest in old people. This study focuses on clinicopathological profile CMM and indicators diagnostic-therapeutic performance older patients. Methods retrospective population-based cohort included 1,368 incident CMM, as recorded 2017 by Regional Veneto Cancer Registry (Northeast Italy). Older subjects were defined ≥ 80, 65–79, adults < 65 years age. strength association between pairs variables was tested Cramer’s-V. Using age groups dependent variable, ordered logistic regression fitted using profiles covariates. each three age-groups, clinical computed Clopper-Pearson exact method. Results Compared to patients aged younger than 80 (1,187), (181; 13.2%) featured different topography, a higher prevalence ulcers (43.3% versus 12.7%; p 0.001), Breslow index ( lower tumor-infiltrating lymphocytes (64.4% 76.5%, 0.01), more advanced pTNM stage at presentation 0.001). Elderly with positive sentinel-lymph node less frequently underwent sentinel- lymph biopsy lymphadenectomy (60.0% 94.2%, 44.4% 85.5%, respectively; Conclusions patients, shows distinctive profile. present results provide critical information optimize secondary prevention strategies refine procedures tailored

Language: Английский

Citations

6
Cutaneous Oncology: Strategies for Melanoma Prevention, Diagnosis, and Therapy DOI Creative Commons

Wajeeha Saeed,

Esha Shahbaz, Quratulain Maqsood

et al.

Cancer Control, Journal Year: 2024, Volume and Issue: 31

Published: Jan. 1, 2024

Skin cancer comprises one-third of all diagnosed cases and remains a major health concern. Genetic environmental parameters serve as the two main risk factors associated with development skin cancer, ultraviolet radiation being most common factor. Studies have also found fair complexion, arsenic toxicity, indoor tanning, family history among prevailing causes cancer. Prevention early diagnosis play crucial role in reducing frequency ensuring effective management Recent studies focused on exploring minimally invasive or non-invasive diagnostic technologies along artificial intelligence to facilitate rapid accurate diagnosis. The treatment ranges from traditional surgical excision various advanced methods such phototherapy, radiotherapy, immunotherapy, targeted therapy, combination therapy. introduction new checkpoint inhibitors personalized immunotherapy enhancing efficacy. Advancements multi-omics, nanotechnology, further deepened understanding mechanisms underlying tumoral growth their interaction therapeutic effects, which has paved way for precision oncology. This review aims highlight recent advancements provide an overview existing emerging diagnostic, prognostic, modalities, while highlighting areas that require research bridge knowledge gaps.

Language: Английский

Citations

6
Cutaneous Squamous Cell Carcinoma DOI

Mallory Suhling,

T. E. Thompson,

Imran Uddin

et al.

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25

Published: Jan. 1, 2024

Citations

6
Targeting tumor-associated macrophages: Novel insights into immunotherapy of skin cancer DOI Creative Commons
Jun Liu, Jiaye Lu,

Ling Wu

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The incidence of skin cancer is currently increasing, and conventional treatment options inadequately address the demands disease management. Fortunately, recent rapid advancement immunotherapy, particularly immune checkpoint inhibitors (ICIs), has ushered in a new era for numerous patients. However, efficacy immunotherapy remains suboptimal due to impact tumor microenvironment (TME). Tumor-associated macrophages (TAMs), major component TME, play crucial roles invasion, metastasis, angiogenesis, evasion, significantly impacting development. Consequently, TAMs have gained considerable attention years, their been extensively studied various tumors. specific regulatory mechanisms remain unclear. This paper aims elucidate origin classification TAMs, investigate interactions between cells, comprehensively understand precise by which contribute pathogenesis different types cancer, finally discuss current strategies targeting cancer. With emphasis on interrelationship this posits that therapeutic modalities centered hold promise augmenting harmonizing with prevailing clinical interventions thereby charting novel trajectory advancing landscape immunotherapeutic approaches

Language: Английский

Citations

5
Isorhamnetin: what is the in vitro evidence for its antitumor potential and beyond? DOI Creative Commons
Jiaming Lei,

Jianbao Yang,

Cuiyu Bao

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 8, 2024

Isorhamnetin (ISO) is a phenolic compound belonging to flavonoid family, showcasing important in vitro pharmacological activities such as antitumor, anti-inflammation, and organ protection. ISO predominantly extracted from Hippophae rhamnoides L . This plant well-known China abroad because of its “medicinal food homologous” characteristics. As noteworthy natural drug candidate, has received considerable attention recent years owing low cost, wide availability, high efficacy, toxicity, minimal side effects. To comprehensively elucidate the multiple biological functions ISO, particularly antitumor other potentials, literature search was conducted using electronic databases including Web Science, PubMed, Google Scholar, Scopus. review primarily focuses on ISO’s ethnopharmacology. By synthesizing advancements made existing research, it found that general effects involve series protection cardiovascular cerebrovascular, antioxidant, more. illustrates providing theoretical basis for further research new development ISO.

Language: Английский

Citations

5
LncRNA MALAT1 in Keratinocyte function: A review of recent advances DOI Creative Commons
Yaneli Juárez-Vicuña, Dayanara Ruiz-Ojeda, Javier González-Ramírez

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(2), P. 594 - 601

Published: Feb. 1, 2024

Keratinocytes, the principal epidermal cells, play a vital role in maintaining structural integrity and functionality of skin. Beyond their protective role, keratinocytes are key contributors to process wound healing, as they migrate injury sites, proliferate, generate new layers epidermis, facilitating tissue repair remodeling. Moreover, actively participate skin's immune responses, expressing pattern recognition receptors (PRRs) detect microbial components interact with cells influence adaptive immunity. Keratinocytes express diverse repertoire signaling pathways, transcription factors, epigenetic regulators regulate growth, differentiation, response environmental cues. Among these regulatory elements, long non-coding RNAs (lncRNAs) have emerged essential players keratinocyte biology. LncRNAs, including MALAT1, roles gene regulation cellular processes, influencing proliferation, migration, stimuli. Dysregulation specific lncRNAs such MALAT1 can disrupt homeostasis, leading impaired compromised barrier integrity, contributing pathogenesis various skin disorders. Understanding intricate interplay between offers promising insights into molecular underpinnings health disease, potential implications for targeted therapies advancements dermatological research. Hence, our objective is provide comprehensive summary available knowledge concerning relationship MALAT1.

Language: Английский

Citations

4
Exploring nanocomposite materials in clinical dermatology: Innovations for treating skin diseases DOI Creative Commons
Sandipan Dasgupta, Subhasundar Maji, Sanjay Dey

et al.

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 7, P. 100139 - 100139

Published: Jan. 1, 2025

Language: Английский

Citations

0