Diabetic Cardiomyopathy

Circulation Research, Journal Year: 2018, Volume and Issue: 122(4), P. 624 - 638

Published: Feb. 15, 2018

Heart failure and related morbidity mortality are increasing at an alarming rate, in large part, because of increases aging, obesity, diabetes mellitus. The clinical outcomes associated with heart considerably worse for patients mellitus than those without In people mellitus, the presence myocardial dysfunction absence overt coronary artery disease, valvular other conventional cardiovascular risk factors, such as hypertension dyslipidemia, has led to descriptive terminology, diabetic cardiomyopathy. prevalence cardiomyopathy is parallel increase Diabetic initially characterized by fibrosis, dysfunctional remodeling, diastolic dysfunction, later systolic eventually failure. Impaired cardiac insulin metabolic signaling, mitochondrial oxidative stress, reduced nitric oxide bioavailability, elevations advanced glycation end products collagen-based cardiomyocyte extracellular matrix stiffness, impaired calcium handling, inflammation, renin-angiotensin-aldosterone system activation, autonomic neuropathy, endoplasmic reticulum microvascular a myriad abnormalities have all been implicated development progression Molecular mechanisms linked underlying pathophysiological changes include AMP-activated protein kinase, peroxisome proliferator-activated receptors, O-linked N-acetylglucosamine, kinase C, microRNA, exosome pathways. aim this review provide contemporary view these instigators cardiomyopathy, well mechanistically based strategies prevention treatment

Language: Английский

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miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

Acta Pharmacologica Sinica, Journal Year: 2018, Volume and Issue: 39(7), P. 1073 - 1084

Published: June 7, 2018

Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in world. Although considerable progress has been made diagnosis, treatment prognosis CVD, there is still a critical need for novel diagnostic biomarkers new therapeutic interventions to decrease incidence this disease. Recently, increasing evidence that circulating miRNAs (miRNAs), i.e. endogenous, stable, single-stranded, short, non-coding RNAs, can be used as CVD. Furthermore, represent potential targets several cardiovascular disorders. In review we provides an overview effects CVD; including heart failure, acute myocardial infarction, arrhythmias pulmonary hypertension; on levels miRNAs. addition, use miRNA also discussed, well challenges recommendations their diagnosis

Language: Английский

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Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

Ageing Research Reviews, Journal Year: 2018, Volume and Issue: 47, P. 214 - 277

Published: July 30, 2018

Use of the frailty index to measure an accumulation deficits has been proven a valuable method for identifying elderly people at risk increased vulnerability, disease, injury, and mortality. However, complementary molecular biomarkers or ideally biomarker panels have not yet identified. We conducted systematic search identify candidates panel.Gene expression databases were searched (http://genomics.senescence.info/genes including GenAge, AnAge, LongevityMap, CellAge, DrugAge, Digital Aging Atlas) genes regulated in aging, longevity, age-related diseases with focus on secreted factors molecules detectable body fluids as potential biomarkers. Factors broadly expressed, related several "hallmark aging" pathways well used predicted other disease settings, particularly pathologies, This set was further expanded according expertise experience authors. In next step, assigned six pathways, namely (1) inflammation, (2) mitochondria apoptosis, (3) calcium homeostasis, (4) fibrosis, (5) NMJ (neuromuscular junction) neurons, (6) cytoskeleton hormones, (7) principles extensive literature performed each candidate explore their priority biomarkers.A total 44 markers evaluated seven categories listed above, 19 awarded high score, 22 identified medium three low priority. category identified.Biomarker would be value better than single markers. Based our we propose core panel consisting CXCL10 (C-X-C motif chemokine ligand 10), IL-6 (interleukin 6), CX3CL1 (C-X3-C 1), GDF15 (growth differentiation factor 15), FNDC5 (fibronectin type III domain containing 5), vimentin (VIM), regucalcin (RGN/SMP30), calreticulin, PLAU (plasminogen activator, urokinase), AGT (angiotensinogen), BDNF (brain derived neurotrophic factor), progranulin (PGRN), α-klotho (KL), FGF23 (fibroblast growth 23), FGF21, leptin (LEP), miRNA (micro Ribonucleic acid) (to defined), AHCY (adenosylhomocysteinase) KRT18 (keratin 18). An also include pentraxin (PTX3), sVCAM/ICAM (soluble vascular cell adhesion molecule 1/Intercellular defensin α, APP (amyloid beta precursor protein), LDH (lactate dehydrogenase), S100B (S100 binding protein B), TGFβ (transforming beta), PAI-1 activator inhibitor TGM2 (transglutaminase 2), sRAGE receptor advanced glycosylation end products), HMGB1 (high mobility group box C3/C1Q (complement 3/1Q), ST2 (Interleukin 1 like agrin (AGRN), IGF-1 (insulin-like resistin (RETN), adiponectin (ADIPOQ), ghrelin (GHRL), hormone (GH), microparticle GpnmB (glycoprotein nonmetastatic melanoma B) lactoferrin (LTF). believe that these need experimentally explored animal models frail cohorts order ascertain diagnostic, prognostic therapeutic potential.

Language: Английский

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Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2017, Volume and Issue: unknown, P. 1 - 12

Published: Nov. 16, 2017

Hypoxia treatment enhances paracrine effect of mesenchymal stem cells (MSCs). The aim this study was to investigate whether exosomes from hypoxia-treated MSCs (ExoH) are superior those normoxia-treated (ExoN) for myocardial repair. Mouse bone marrow-derived were cultured under hypoxia or normoxia 24 h, and conditioned media intramyocardially injected into infarcted heart C57BL/6 mouse. ExoH resulted in significantly higher survival, smaller scar size better cardiac functions recovery. conferred increased vascular density, lower cardiomyocytes (CMs) apoptosis, reduced fibrosis recruitment progenitor the relative ExoN. MicroRNA analysis revealed levels microRNA-210 (miR-210) compared with Transfection a miR-210 mimic endothelial (ECs) CMs similar biological effects as ExoH. expression neutral sphingomyelinase 2 (nSMase2) which is crucial exosome secretion. Blocking activity nSMase2 secretion abrogated beneficial In conclusion, hypoxic culture augments activities their secreted exosomes, responsible at least part enhanced cardioprotective actions derived cells.

Language: Английский

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Novel biomarkers for cardiovascular risk prediction.

PubMed, Journal Year: 2017, Volume and Issue: 14(2), P. 135 - 150

Published: Feb. 1, 2017

Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. The primary prevention CVD dependent upon ability to identify high-risk individuals long before development overt events. This highlights need for accurate risk stratification. An increasing number novel biomarkers have been identified predict cardiovascular Biomarkers play a critical role in definition, prognostication, decision-making regarding management review focuses on variety promising that provide diagnostic prognostic information. myocardial tissue-specific biomarker cardiac troponin, high-sensitivity assays heart-type fatty acid binding proteinall help diagnose infarction (MI) early hours following symptoms. Inflammatory markers such as growth differentiation factor-15, C-reactive protein, fibrinogen, uric MI death. Pregnancy-associated plasma protein A, myeloperoxidase, matrix metalloproteinases acute coronary syndrome. Lipoprotein-associated phospholipase A2 secretory incident recurrent Finally, elevated natriuretic peptides, ST2, endothelin-1, mid-regional-pro-adrenomedullin, copeptin, galectin-3 all well validated heart failure stratification information failure. Rapidly developing new areas, assessment micro-RNA, are also explored. All reflect different aspects atherosclerosis.

Language: Английский

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Systems biology in cardiovascular disease: a multiomics approach

Nature Reviews Cardiology, Journal Year: 2020, Volume and Issue: 18(5), P. 313 - 330

Published: Dec. 18, 2020

Language: Английский

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Biomaterials and cells for cardiac tissue engineering: Current choices

Materials Science and Engineering C, Journal Year: 2017, Volume and Issue: 79, P. 950 - 957

Published: May 17, 2017

Language: Английский

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Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease

Atherosclerosis, Journal Year: 2019, Volume and Issue: 285, P. 1 - 9

Published: March 23, 2019

Language: Английский

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MicroRNA Biomarkers and Platelet Reactivity

Circulation Research, Journal Year: 2017, Volume and Issue: 120(2), P. 418 - 435

Published: Jan. 19, 2017

Over the last few years, several groups have evaluated potential of microRNAs (miRNAs) as biomarkers for cardiometabolic disease. In this review, we discuss emerging literature on role miRNAs and other small noncoding RNAs in platelets circulation, use platelet activation. Platelets are a major source miRNAs, YRNAs, circular RNAs. By harnessing multiomics approaches, may gain valuable insights into their function. Because not all detectable also created gene ontology annotation circulating using term extracellular space part blood plasma. Finally, share key measuring miRNAs. We propose ways to standardize miRNA measurements, particular by platelet-poor plasma avoid confounding caused residual or adding RNase inhibitors serum reduce degradation. This should enhance comparability measurements across different cohorts. provide recommendations future biomarker studies, emphasizing need accurate interpretation within biological methodological context.

Language: Английский

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The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 67, P. 101271 - 101271

Published: Feb. 9, 2021

While the elderly segment of population continues growing in importance, neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition, exercise, and education, among others, influence ageing progression, throughout life. Notably, Central Nervous System (CNS) can benefit from nutritional strategies dietary interventions that prevent signs senescence, cognitive decline or Alzheimer's disease Parkinson's Disease. The polyphenol Resveratrol (RV) possesses antioxidant cytoprotective effects, producing neuroprotection several organisms. oxidative stress (OS) occurs because Reactive oxygen species (ROS) accumulation has been proposed to explain cause ageing. One most harmful effects ROS cell is DNA damage. Nevertheless, there also evidence demonstrating OS produce other molecular changes mitochondrial dysfunction, inflammation, apoptosis, epigenetic modifications, others. Interestingly, RV a potent pleiotropic actions, exerting its activity through various pathways. In addition, recent shown mediates involved function CNS persists across generations. Furthermore, it demonstrated interacts with gut microbiota, showing modifications bacterial composition associated beneficial effects. this review, we give comprehensive overview main mechanisms action different experimental models, including clinical trials discuss how interconnection these events could neuroprotective induced by RV.

Language: Английский

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