Influence of human gut microbiome on the healthy and the neurodegenerative aging DOI Creative Commons
Alejandro Borrego-Ruiz, Juan J. Borrego

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 194, P. 112497 - 112497

Published: June 27, 2024

The gut microbiome plays a crucial role in host health throughout the lifespan by influencing brain function during aging. microbial diversity of human decreases aging process and, as consequence, several mechanisms increase, such oxidative stress, mitochondrial dysfunction, inflammatory response, and dysbiosis. Moreover, evidence indicates that neurodegeneration are closely related; consequently, may serve novel marker elderly. In this narrative study, we investigated how changes composition occur influence to various neuropathological disorders, mild cognitive impairment (MCI), dementia, Alzheimer's disease (AD), Parkinson's (PD); which possible govern relationship between impairment. addition, studies suggest be potential target improve hallmarks promote healthy cognition; therefore, current future therapeutic interventions have been also reviewed.

Language: Английский

Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging DOI Creative Commons
Klaudia Jomová,

Renáta Raptová,

Suliman Yousef Alomar

et al.

Archives of Toxicology, Journal Year: 2023, Volume and Issue: 97(10), P. 2499 - 2574

Published: Aug. 19, 2023

Abstract A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or “good stress” characterized by low to mild levels oxidants involved in the regulation various biochemical transformations such carboxylation, hydroxylation, peroxidation, modulation signal transduction pathways Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2–related 2 (Nrf2) other processes. Increased ROS/RNS, generated from both endogenous (mitochondria, NADPH oxidases) and/or exogenous sources (radiation, certain drugs, foods, cigarette smoking, pollution) result a harmful condition stress (“bad stress”). Although it widely accepted, that many chronic diseases are multifactorial origin, they share common denominator. Here we review importance mechanisms through which contributes pathological states an organism. Attention focused on chemistry ROS RNS (e.g. superoxide radical, hydrogen peroxide, hydroxyl radicals, peroxyl nitric oxide, peroxynitrite), their role damage DNA, proteins, membrane lipids. Quantitative qualitative assessment biomarkers also discussed. Oxidative pathology cancer, cardiovascular diseases, diabetes, neurological disorders (Alzheimer’s Parkinson’s Down syndrome), psychiatric (depression, schizophrenia, bipolar disorder), renal disease, lung disease (chronic pulmonary obstruction, cancer), aging. The concerted action antioxidants ameliorate effect achieved antioxidant enzymes (Superoxide dismutases-SODs, catalase, glutathione peroxidase-GPx), small molecular weight (vitamins C E, flavonoids, carotenoids, melatonin, ergothioneine, others). Perhaps one most effective vitamin first line defense against peroxidation promising approach appears be use flavonoids), showing weak prooxidant properties may boost cellular systems thus act preventive anticancer agents. Redox metal-based enzyme mimetic compounds potential pharmaceutical interventions sirtuins therapeutic targets for age-related anti-aging strategies

Language: Английский

Citations

964
Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases DOI Creative Commons
Shuai Jiang, Hui Liu, Chunbao Li

et al.

Foods, Journal Year: 2021, Volume and Issue: 10(8), P. 1854 - 1854

Published: Aug. 11, 2021

Oxidative stress is a status of imbalance between oxidants and antioxidants, resulting in molecular damage interruption redox signaling an organism. Indeed, oxidative has been associated with many metabolic disorders due to unhealthy dietary patterns may be alleviated by properly increasing the intake antioxidants. Thus, it quite important adopt healthy mode regulate maintain cell tissue homeostasis, preventing inflammation chronic diseases. This review focuses on links nutrients health, summarizing role 'unhealthy' pathway activities individuals how further regulated balanced diets.

Language: Английский

Citations

133
Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics DOI
Lucia Migliore, Fabio Coppedè

Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(11), P. 643 - 660

Published: Sept. 30, 2022

Language: Английский

Citations

124
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence DOI Creative Commons
Angelica Varesi, Salvatore Chirumbolo, Lucrezia Irene Maria Campagnoli

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1224 - 1224

Published: June 22, 2022

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and oncogenic proteins. Although beneficial protective several physiological processes, excessive senescent burden has been involved various pathological conditions including aging, tissue dysfunction chronic diseases. Oxidative stress (OS) can drive due a loss balance between pro-oxidant stimuli antioxidant defences. Therefore, the identification characterization compounds capable preventing or counteracting phenotype major interest. However, despite considerable number studies, comprehensive overview main molecules OS-induced still lacking. Here, besides brief description molecular mechanisms implicated OS-mediated we review discuss role enzymes, mitochondria-targeting compounds, vitamins, carotenoids, organosulfur nitrogen non-protein molecules, minerals, flavonoids, non-flavonoids with anti-aging potential, therefore offering insights into innovative lifespan-extending approaches.

Language: Английский

Citations

93
Antioxidant Therapeutic Strategies in Neurodegenerative Diseases DOI Open Access
Constanza Morén,

Ruth Mary deSouza,

Darly Milena Giraldo

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 9328 - 9328

Published: Aug. 19, 2022

The distinguishing pathogenic features of neurodegenerative diseases include mitochondrial dysfunction and derived reactive oxygen species generation. neural tissue is highly sensitive to oxidative stress this a prominent factor in both chronic acute neurodegeneration. Based on this, therapeutic strategies using antioxidant molecules towards redox equilibrium have been widely used for the treatment several brain pathologies. Globally, polyphenols, carotenes vitamins are among most typical exogenous agents that tested neurodegeneration as adjunctive therapies. However, other types antioxidants, including hormones, such melatonin, also considered neuroprotective different contexts. This review highlights relevant targets main disorders Alzheimer's disease, Parkinson's Huntington's disease less represented amyotrophic lateral sclerosis, well traumatic injury, while summarizing latest randomized placebo-controlled trials.

Language: Английский

Citations

75
Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants DOI Creative Commons
Feng Jin,

Youle Zheng,

Mingyue Guo

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(10), P. 3988 - 4024

Published: July 16, 2023

In recent years, growing awareness of the role oxidative stress in brain health has prompted antioxidants, especially dietary to receive attention as possible treatments strategies for patients with neurodegenerative diseases (NDs). The most widely studied antioxidants include active substances such vitamins, carotenoids, flavonoids and polyphenols. Dietary are found usually consumed foods fresh fruits, vegetables, nuts oils gaining popularity due recently their potential preventive protective agents against NDs, well abundant natural sources, generally non-toxic nature, ease long-term consumption. This review article examines development explores ‘two-sidedness’ blood–brain barrier (BBB) a nervous system an impeding use drug medicinal products and/or supplements prevention therapy reviews BBB permeability common suplements efficacy treatment NDs. Finally, current challenges future directions NDs using discussed, useful information on is provided.

Language: Английский

Citations

67
Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer's disease DOI
Licong Yang, Yabin Wang, Zhiwei Li

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 310, P. 120714 - 120714

Published: Feb. 18, 2023

Language: Английский

Citations

48
Resveratrol Activates Antioxidant Protective Mechanisms in Cellular Models of Alzheimer’s Disease Inflammation DOI Creative Commons
Clara Bartra, Yi Yuan, Kristijan Vuraić

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 177 - 177

Published: Jan. 31, 2024

Resveratrol is a natural phenolic compound with known benefits against neurodegeneration. We analyzed in vitro the protective mechanisms of resveratrol proinflammatory monomeric C-reactive protein (mCRP). mCRP increases risk AD after stroke and we previously demonstrated that intracerebral induces AD-like dementia mice. Here, used BV2 microglia treated for 24 h presence or absence resveratrol. Cells conditioned media were collected analysis. Lipopolysaccharide (LPS) has also been implicated progression so LPS was as resveratrol-sensitive reference agent. at concentration 50 µg/mL activated nitric oxide pathway NLRP3 inflammasome pathway. Furthermore, induced cyclooxygenase-2 release cytokines. effectively inhibited these changes increased expression antioxidant enzyme genes Cat Sod2. As central defense, hub Sirt1 Nfe2l2 nuclear translocation signal transducer NF-ĸB. Proinflammatory by primary mixed glial cultures protected This work provides mechanistic insight into preventing agents.

Language: Английский

Citations

22
The hormesis principle of neuroplasticity and neuroprotection DOI Creative Commons
Mark P. Mattson, Rehana K. Leak

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 315 - 337

Published: Jan. 10, 2024

Language: Английский

Citations

20
Resveratrol—A Promising Therapeutic Agent with Problematic Properties DOI Creative Commons
Lyubomira Radeva, Krassimira Yoncheva

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 134 - 134

Published: Jan. 19, 2025

Resveratrol is a natural polyphenol (stilbenoid), which can be found in grape skin, red wine, blueberries, peanuts and others. The biological properties of resveratrol, particular antioxidant, anti-inflammatory, anticancer, estrogenic, vasorelaxant cardioprotective activity, are the main reason for its importance medicine pharmacy. Despite all advantages, however, there many problems related to this polyphenolic substance, such as low stability, water insolubility, poor bioavailability fast metabolism. For reason, scientists currently searching different approaches dealing with these problematic improving therapeutic usage resveratrol. This review summarizes mechanisms effects determined vitro vivo, limitations drug. article emphasizes new improvement resveratrol delivery, nanoencapsulation, formation nanocrystals, prodrugs structure analogues.

Language: Английский

Citations

3