Potential role of insulin on the pathogenesis of depression DOI Creative Commons

Xiao Han Zou,

Li Sun, Wei Yang

et al.

Cell Proliferation, Journal Year: 2020, Volume and Issue: 53(5)

Published: April 13, 2020

Abstract The regulation of insulin on depression and depression‐like behaviour has been widely reported. Insulin activation its receptor can promote learning memory, affect the hypothalamic‐pituitary‐adrenal axis (HPA) balance, regulate secretion neurotrophic factors neurotransmitters, interact with gastrointestinal microbiome, exert neuroprotective effects have an impact depression. However, role remains largely unclear. Therefore, in this review, we summarized potential It may provide new insight for clarifying pathogenesis

Language: Английский

The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders DOI Creative Commons
Katarzyna Socała, Urszula Doboszewska, Aleksandra Szopa

et al.

Pharmacological Research, Journal Year: 2021, Volume and Issue: 172, P. 105840 - 105840

Published: Aug. 24, 2021

Emerging evidence indicates that the gut microbiota play a crucial role in bidirectional communication between and brain suggesting microbes may shape neural development, modulate neurotransmission affect behavior, thereby contribute to pathogenesis and/or progression of many neurodevelopmental, neuropsychiatric, neurological conditions. This review summarizes recent data on microbiota-gut-brain axis pathophysiology neuropsychiatric disorders including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, epilepsy. Also, involvement co-existing with conditions is highlighted. We discuss from both vivo preclinical experiments clinical reports including: (1) studies germ-free animals, (2) exploring composition animal models diseases or humans, (3) evaluating effects probiotic, prebiotic antibiotic treatment as well (4) fecal transplantation.

Language: Английский

Citations

499
Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health DOI Open Access

Brigitte M. González Olmo,

Michael J. Butler, Ruth M. Barrientos

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(1), P. 196 - 196

Published: Jan. 10, 2021

The relatively rapid shift from consuming preagricultural wild foods for thousands of years, to postindustrial semi-processed and ultra-processed endemic the Western world less than 200 years ago did not allow evolutionary adaptation commensal microbial species that inhabit human gastrointestinal (GI) tract, this has significantly impacted gut health. microbiota, diverse dynamic population microbes, been demonstrated have extensive important interactions with digestive, immune, nervous systems. diet-induced dysbiosis microbiota shown negatively impact digestive physiology, pathogenic effects on immune system, and, in turn, cause exaggerated neuroinflammation. Given tremendous amount evidence linking neuroinflammation neural dysfunction, it is no surprise diet implicated development many diseases disorders brain, including memory impairments, neurodegenerative disorders, depression. In review, we discuss each these concepts understand how what eat can lead cognitive psychiatric diseases.

Language: Английский

Citations

113
Irritable bowel syndrome and mental health comorbidity — approach to multidisciplinary management DOI Open Access
Heidi M. Staudacher, Christopher J. Black, Scott Teasdale

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(9), P. 582 - 596

Published: June 2, 2023

Language: Английский

Citations

100
Inflammation, Lifestyle Factors, and the Microbiome‐Gut‐Brain Axis: Relevance to Depression and Antidepressant Action DOI Creative Commons
Francisco Donoso, John F. Cryan,

Loreto Olavarría‐Ramírez

et al.

Clinical Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 113(2), P. 246 - 259

Published: March 12, 2022

Depression is considered a major public health concern, where existing pharmacological treatments are not equally effective across all patients. The pathogenesis of depression involves the interaction complex biological components, such as immune system and microbiota‐gut‐brain axis. Adjunctive lifestyle‐oriented approaches for depression, including physical exercise special diets promising therapeutic options when combined with traditional antidepressants. However, mechanisms action these strategies incompletely understood. Accumulating evidence suggests that specific dietary regimens can modulate both gut microbiota composition. Here, we review current information about to alleviate their crosstalk inflammatory microbiome. We further discuss role axis possible mediator adjunctive therapies through mechanisms. Finally, future manipulate potential use exercise, interventions, prebiotics/probiotics, fecal transplantation.

Language: Английский

Citations

97
Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options DOI Creative Commons
Akash Kumar, Jhilam Pramanik, Nandani Goyal

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 565 - 565

Published: April 9, 2023

The gut microbiota is critical for maintaining human health and the immunological system. Several neuroscientific studies have shown significance of in developing brain systems. are interconnected a bidirectional relationship, as research on microbiome–gut–brain axis shows. Significant evidence links anxiety depression disorders to community microbes that live gastrointestinal Modified diet, fish omega-3 fatty acid intake, macro- micro-nutrient prebiotics, probiotics, synbiotics, postbiotics, fecal transplantation, 5-HTP regulation may all be utilized alter treatment approach. There few preclinical clinical effectiveness reliability various therapeutic approaches anxiety. This article highlights relevant association with different possibilities modification.

Language: Английский

Citations

49
Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3 DOI Creative Commons
Wenzhi Hao, Qingyu Ma, Lu Wang

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Feb. 20, 2024

Abstract Background Remodeling eubiosis of the gut microenvironment may contribute to preventing occurrence and development depression. Mounting experimental evidence has shown that complement C3 signaling is associated with pathogenesis depression, disruption microbiota be an underlying cause system activation. However, mechanism by which participates in gut-brain crosstalk depression remains unknown. Results In present study, we found chronic unpredictable mild stress (CUMS)-induced mice exhibited obvious depression-like behavior as well cognitive impairment, was significant dysbiosis, especially enrichment Proteobacteria elevation microbiota-derived lipopolysaccharides (LPS). addition, peripheral central activation C3/CR3-mediated aberrant synaptic pruning microglia have also been observed. Transplantation from CUMS-induced model into specific pathogen-free germ-free induced concomitant impairment recipient mice, accompanied increased C3/CR3 pathway prefrontal cortex abnormalities microglia-mediated pruning. Conversely, antidepressants fecal transplantation antidepressant-treated donors improved behaviors restored microbiome disturbances depressed mice. Concurrently, inhibition pathway, amelioration abnormal pruning, expression synapsin postsynaptic density protein 95 were Collectively, our results revealed dysbiosis induces through synapse C3, key targeting microbes treat Conclusions Our findings provide novel insights involvement chemotactic

Language: Английский

Citations

29
Diet, nutrients and the microbiome DOI
Wendy J. Dahl, Daniela Rivero‐Mendoza,

Jason M. Lambert

et al.

Progress in molecular biology and translational science, Journal Year: 2020, Volume and Issue: unknown, P. 237 - 263

Published: Jan. 1, 2020

Language: Английский

Citations

128
Remodeling of the gut microbiome during Ramadan-associated intermittent fasting DOI Creative Commons
Junhong Su, Yueying Wang, Xiaofang Zhang

et al.

American Journal of Clinical Nutrition, Journal Year: 2020, Volume and Issue: 113(5), P. 1332 - 1342

Published: Nov. 25, 2020

Intermittent fasting is a popular dietary intervention with perceived relatively easy compliance and linked to various health benefits, including weight loss improvement in blood glucose concentrations. The mechanistic explanations underlying the beneficial effects of intermittent remain largely obscure but may involve alterations gut microbiota.We sought establish 1 mo on microbiome.We took advantage being voluntarily observed during Islamic faith-associated Ramadan sampled feces blood, as well collected longitudinal physiologic data 2 cohorts, different years. fecal microbiome was determined by 16S sequencing. Results were contrasted age- body weight-matched controls correlated parameters (e.g., mass calorie intake).We that Ramadan-associated increased diversity specifically associated upregulation Clostridiales order-derived Lachnospiraceae [no 24.6 ± 13.67 compared 39.7 15.9 relative abundance (%); linear discriminant analysis = 4.9, P < 0.001 coupled effect size measurements] Ruminococcaceae 13.4 6.9 23.2 12.9 4.7, bacterial families. Microbiome composition returned baseline upon cessation feeding. Furthermore, changes concentrations mirrored fasting-provoked parameters.Intermittent provokes substantial remodeling microbiome. butyric acid-producing provides an obvious possible explanation for fasting.

Language: Английский

Citations

101
Autism Spectrum Disorder Associated With Gut Microbiota at Immune, Metabolomic, and Neuroactive Level DOI Creative Commons
Enriqueta García-Gutiérrez, Arjan Narbad, Juan M. Rodrı́guez

et al.

Frontiers in Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: Oct. 8, 2020

There is increasing evidence suggesting a link between the autism spectrum disorder (ASD) and gastrointestinal (GI) microbiome. Experimental clinical studies have shown that patients diagnosed with ASD display alterations of gut microbiota. These do not only extend to microbiota composition but also metabolites they produce, as result its connections diet bidirectional interaction host. Thus, production neurotransmitters stimulate immune system influence central nervous (CNV) by stimulation vagal nerve, an example gut-brain axis pathway. In this review we compose overview interconnectivity different GI-related elements been associated development severity in animal models. We potential biomarkers be used future unlock further interventions treatment ASD.

Language: Английский

Citations

97
Molecular Mechanisms of Microbiota-Mediated Pathology in Irritable Bowel Syndrome DOI Open Access
Yoshiyuki Mishima, Shunji Ishihara

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(22), P. 8664 - 8664

Published: Nov. 17, 2020

Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders, and accumulating evidence gained in both preclinical clinical studies indicate involvement enteric microbiota its pathogenesis. Gut resident appear to influence brain activity through nervous system, while their composition function are affected by central system. Based on these results, term "brain-gut-microbiome axis" has been proposed have become a potential therapeutic target IBS cases. However, details regarding microbe-related pathophysiology remain elusive. This review summarizes existing knowledge molecular mechanisms pathogenesis as well recent progress related microbiome-derived neurotransmitters, compounds, metabolites, neuroendocrine factors, enzymes.

Language: Английский

Citations

71