Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 10, 2024
Glioblastoma
(GBM)
is
a
highly
malignant,
invasive,
and
poorly
prognosed
brain
tumor.
Unfortunately,
active
comprehensive
treatment
does
not
significantly
prolong
patient
survival.
With
the
deepening
of
research,
it
has
been
found
that
gut
microbiota
plays
certain
role
in
GBM,
can
directly
or
indirectly
affect
efficacy
immune
checkpoint
inhibitors
(ICIs)
various
ways.
(1)
The
metabolites
produced
by
host’s
homeostasis,
these
function
distribution
cells,
promote
inhibit
inflammatory
responses,
phenotype,
angiogenesis,
response,
cell
infiltration
GBM
thereby
affecting
effectiveness
ICIs.
(2)
Some
members
may
reverse
T
inhibition,
increase
anti-tumor
activity,
ultimately
improve
ICIs
targeting
specific
immunosuppressive
cytokines.
(3)
participate
metabolic
process
drugs,
which
degrade,
transform,
produce
metabolites,
effective
concentration
bioavailability
drugs.
Optimizing
structure
help
(4)
also
regulate
status
through
axis
communication,
progression
therapeutic
response
to
(5)
Given
importance
for
ICI
therapy,
researchers
have
begun
exploring
use
fecal
transplantation
(FMT)
transplant
healthy
optimized
patients,
order
their
enhance
therapy.
Preliminary
studies
suggest
FMT
therapy
some
patients.
In
summary,
crucial
regulating
with
deeper
understanding
relationship
between
tumor
immunity,
expected
develop
more
precise
personalized
strategies
prognosis.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Dysbiosis
of
the
gut
microbiota
is
emerging
as
a
pivotal
factor
in
pathogenesis
colorectal
cancer
(CRC).
Ginsenoside
Rh4
(Rh4)
an
active
compound
isolated
from
ginseng
with
beneficial
effects
modulating
intestinal
inflammation
and
dysbiosis,
but
how
regulates
to
alleviate
CRC
remains
underexplored.
We
investigated
impact
on
mechanism
its
action
inhibiting
via
modulation
microbiota.
used
AOM/DSS
model
employed
transcriptomics,
genomics
metabolomics
techniques
explore
inhibitory
CRC.
Furthermore,
we
experiments
involving
antibiotic
treatment
fecal
transplantation
(FMT)
investigate
role
Finally,
elucidated
key
functional
bacteria
metabolites
regulated
by
Our
research
findings
indicated
that
repaired
barrier
damage
caused
CRC,
alleviated
inflammation,
inhibited
development
Additionally,
microbiota-dependent
manner.
increased
diversity
microbiota,
enriched
probiotic
Akkermansia
muciniphila
(A.
muciniphila),
dysbiosis
Subsequently,
A.
muciniphila-mediated
bile
acid
metabolism.
promoted
production
UDCA
enhancing
activity
7α-hydroxysteroid
dehydrogenase
(7α-HSDH).
further
activated
FXR,
modulated
TLR4-NF-κB
signaling
pathway,
thus
results
confirm
inhibits
manner
microbiota-mediated
metabolism
promoting
UDCA,
which
activates
FXR
receptor
pathway.
has
potential
be
modulator
for
preventing
Lipids in Health and Disease,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Aug. 3, 2024
Despite
centuries
of
traditional
use
silymarin
for
hepatoprotection,
current
randomized
controlled
trial
(RCT)
studies
on
the
effectiveness
in
managing
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
are
limited
and
inconclusive,
particularly
when
it
is
administered
alone.
The
low
bioavailability
highlights
possible
influence
gut
microbiota
silymarin;
however,
no
human
have
investigated
this
aspect.
To
determine
potential
efficacy
improving
MASLD
indicators
to
investigate
underlying
mechanisms
related
microbiota.
In
24-week
randomized,
double-blind,
placebo-controlled
trial,
83
patients
with
were
either
placebo
(n
=
41)
or
(103.2
mg/d,
n
42).
At
0,
12,
24
weeks,
stiffness
hepatic
steatosis
assessed
using
FibroScan,
blood
samples
gathered
biochemical
detection,
while
faecal
collected
at
0
weeks
16S
rRNA
sequencing.
Silymarin
supplementation
significantly
reduced
(LSM,
-0.21
±
0.17
vs.
0.41
0.17,
P
0.015)
serum
levels
γ-glutamyl
transpeptidase
(GGT,
-8.21
3.01
1.23
3.16,
0.042)
ApoB
(-0.02
0.03
0.07
0.03,
0.023)
but
had
significant
effect
attenuation
parameter
(CAP),
other
(aminotransferases,
total
bilirubin,
glucose
lipid
parameters,
hsCRP,
SOD,
UA),
physical
measurements
(DBP,
SBP,
BMI,
WHR,
BF%,
BMR),
APRI
FIB-4
indices.
Gut
analysis
revealed
increased
species
diversity
enrichment
Oscillospiraceae
group.
These
findings
suggest
that
could
improve
patients,
possibly
by
modulating
was
registered
Chinese
Clinical
Trial
Registry
(ChiCTR2200059043).
Foods,
Journal Year:
2025,
Volume and Issue:
14(4), P. 608 - 608
Published: Feb. 12, 2025
As
a
key
component
of
both
traditional
medicine
and
modern
healthcare,
Food–Medicine
Homologous
Herbal
Materials
have
attracted
considerable
attention
in
recent
years.
However,
issues
related
to
the
quality
authenticity
medicinal
materials
on
market
often
arise,
not
only
compromising
their
efficacy
but
also
presenting
potential
risks
consumer
health.
Therefore,
establishment
accurate
efficient
identification
methods
is
crucial
for
ensuring
safety
Food-Medicine
Materials.
This
paper
provides
systematic
review
research
progress
Materials,
starting
with
such
as
morphological
microscopic
identification,
focusing
applications
techniques,
including
biomimetic
recognition,
chromatography,
mass
spectrometry,
chromatography–mass
spectrometry
coupling,
hyperspectral
imaging,
near-infrared
spectroscopy,
terahertz
DNA
barcoding.
Moreover,
it
comprehensive
analysis
fundamental
principles,
advantages,
limitations
these
methods.
Finally,
outlines
current
challenges
faced
by
suggests
future
directions
improvement,
aiming
offer
technical
perspective
identifying
foster
further
development
this
field.
