Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 30, 2023
Abstract
Background
Cuproptosis
is
a
novel
mode
of
cell
death,
which
strongly
related
to
energy
metabolism
in
mitochondria
and
regulated
by
protein
lipoylation.
Currently,
the
molecular
mechanisms
cuproptosis-related
genes
(CRGs)
involved
systemic
lupus
erythematosus
(SLE)
largely
remained
unclear,
our
study
aimed
explore
cuproptosis
CRGs
SLE.
Methods
Bulk
RNA-seq
datasets
were
collected
display
expressions
peripheral
blood
mononuclear
cells
(PBMCs)
SLE
healthy
individuals,
then
ROC
analysis
was
used
establish
diagnostic
models
CRGs.
Next,
immune
infiltration
analyses
applied
reveal
difference
LIAS-low
LIAS-high
group.
Additionally,
WGCNA
performed
find
gene
modules
significantly
corelated
with
LIAS
expression
level.
We
also
functional
enrichment
for
LIAS-related
determine
potential
pathways
development
Finally,
scRNA-seq
dataset
cluster
subsets,
activated
pathways,
cell-cell
interactions
cells.
Result
found
CDKN2A
increased
decreased
patients
compared
individuals.
The
AUC
score
showed
that
had
great
value
than
other
results
proportion
diverse
samples.
sets
level
dephosphorylation
JAK1
SHP1,
phosphorylation
STAT2,
cytokine
signaling
system,
interferon-alpha
beta,
inhibition
JAK
kinase
activity
SOCS1/3
so
on.
communication
CCL-
(CCL5
+
CCR1)
ANNEXIN-
(ANXA1
FPR1)
might
play
an
essential
role
network
between
Conclusions
Above
findings
inferred
LIAS-mediated
involve
comprehensive
cellular
mechanism
cause
occurrence
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 5, 2024
Systemic
lupus
erythematosus
(SLE)
is
a
prevalent
autoimmune
disease
primarily
characterized
by
the
involvement
of
multiple
systems
and
organs.
Cardiovascular
primary
cause
mortality
in
patients
with
SLE,
though
mechanisms
underlying
increased
cardiovascular
risk
SLE
remain
unclear.
Recent
studies
indicate
that
abnormal
activation
programmed
cell
death
(PCD)
signaling
crosstalk
among
various
forms
are
critical
immunopathogenesis
SLE.
Furthermore,
apoptosis,
necroptosis,
pyroptosis,
NETosis,
ferroptosis
recognized
as
key
cellular
processes
pathogenesis
closely
linked
to
cardiac
involvement.
This
review
uniquely
explores
intricate
between
other
pathways,
discussing
their
roles
interactions
Investigating
interplay
PCD
understanding
disease's
offers
opportunities
for
new
therapeutic
interventions.
The
integration
precision
medicine
innovative
strategies
targeting
these
complex
pathways
holds
promise
enhancing
treatment
prospects
Current Opinion in Rheumatology,
Journal Year:
2022,
Volume and Issue:
35(2), P. 82 - 88
Published: Oct. 14, 2022
Although
dysregulated
adaptive
immune
response
has
been
considered
as
the
main
culprit
for
systemic
lupus
erythematosus
(SLE),
emerging
studies
have
indicated
that
innate
immunity,
functioning
upstream
of
acts
an
important
trigger
autoimmune
diseases
and
promotes
SLE
development.
Here,
we
reviewed
most
recent
findings
to
highlight
influence
neutrophils
on
pathogenesis.Neutrophils
participate
in
development
mainly
via
promoting
self-antigen
exposure
autoantibody
production,
advocating
release
type
I
interferons
(IFNs)
other
pro-inflammatory
cytokines,
mediating
tissue
injury.
A
study
revealed
neutrophil
ferroptosis
exerts
a
strong
pathogenic
effect
SLE,
immunity
is
adequate
disrupt
homeostasis
tolerance.Insights
into
role
will
contribute
more
comprehensive
understanding
this
disease
may
propose
novel
clinical
targets
accurate
diagnosis
precision
medicine.
Lupus,
Journal Year:
2023,
Volume and Issue:
32(14), P. 1598 - 1609
Published: Oct. 30, 2023
Background
Cuproptosis
is
a
novel
mode
of
cell
death,
which
strongly
related
to
energy
metabolism
in
mitochondria
and
regulated
by
protein
lipoylation.
Currently,
the
molecular
mechanisms
cuproptosis-related
genes
(CRGs)
involved
systemic
lupus
erythematosus
(SLE)
largely
remained
unclear,
our
study
aimed
explore
cuproptosis
CRGs
SLE.
Methods
Bulk
RNA-seq
datasets
were
collected
display
expressions
peripheral
blood
mononuclear
cells
(PBMCs)
SLE
healthy
individuals,
then
ROC
analysis
was
used
establish
diagnostic
models
CRGs.
Next,
immune
infiltration
analyses
applied
reveal
difference
LIAS-low
LIAS-high
group.
Additionally,
WGCNA
performed
find
gene
modules
significantly
correlated
with
LIAS
expression
level.
We
also
functional
enrichment
for
LIAS-related
determine
potential
pathways
development
Finally,
scRNA-seq
dataset
cluster
subsets,
activated
pathways,
cell-cell
interactions
cells.
Result
found
CDKN2A
increased
decreased
patients
compared
individuals.
The
AUC
score
showed
that
had
great
value
than
other
results
proportion
diverse
samples.
sets
level
dephosphorylation
JAK1
SHP1,
phosphorylation
STAT2,
cytokine
signaling
system,
interferon-alpha
beta,
inhibition
JAK
kinase
activity
SOCS1/3,
so
on.
communication
CCL-
(CCL5
+
CCR1)
ANNEXIN-
(ANXA1
FPR1)
might
play
an
essential
role
network
between
Conclusion
Above
findings
inferred
LIAS-mediated
involve
comprehensive
cellular
mechanism
cause
occurrence
Acta Neurologica Scandinavica,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 8
Published: Sept. 12, 2023
Background.
Migraine
is
a
frequently
observed
neurological
disease
in
patients
with
systemic
lupus
erythematosus.
However,
the
relationship
between
these
two
conditions
still
subject
of
controversy.
Objectives.
Our
aim
was
to
investigate
association
migraine
and
risk
developing
erythematosus
through
meta-analysis
case-control
studies.
Methods.
Following
Preferred
Reporting
Project
for
Systematic
Reviews
Meta-Analysis
statement,
we
conducted
comprehensive
search
following
literature
databases,
including
PubMed,
Embase,
Web
Science,
identify
relevant
articles
published
up
June
2022
using
keywords
“migraine”
“systemic
erythematosus”
as
headings.
If
heterogeneity
expected
be
low
(
%),
pooled
analysis
performed
fixed-effects
model
calculated
by
Mantel-Haenszel
method.
Analysis
this
study
R
software
(http://www.r-project.org).
Results.
Six
experimental
studies
involving
908
participants
were
included
meta-analysis.
The
overall
combined
relative
migraine,
compared
control
group,
1.69
(95%
confidence
interval
(CI):
1.26
2.27).
revealed
minimal
evidence
publication
bias.
Conclusions.
Based
on
our
meta-analysis,
there
suggestive
that
may
have
an
elevated
attacks.
Pharmacological Reviews,
Journal Year:
2023,
Volume and Issue:
76(2), P. 228 - 250
Published: Dec. 13, 2023
Abstract
The
involvement
of
the
prostaglandin
E2
(PGE2)
system
in
cancer
progression
has
long
been
recognized.
PGE2
functions
as
an
autocrine
and
paracrine
signaling
molecule
with
pleiotropic
effects
human
body.
High
levels
intratumoral
overexpression
key
metabolic
enzymes
have
observed
suggested
to
contribute
tumor
progression.
This
claimed
for
different
types
solid
tumors,
including,
but
not
limited
to,
lung,
breast,
colon
cancer.
direct
on
cells
angiogenesis
that
are
known
promote
development.
However,
one
main
mechanisms
behind
driving
cancerogenesis
is
currently
thought
be
anchored
suppressed
antitumor
immunity,
thus
providing
possible
therapeutic
targets
used
immunotherapies.
EP2
EP4,
two
receptors
PGE2,
emerging
being
most
relevant
this
purpose.
review
aims
summarize
roles
immune
its
within
microenvironment.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(8), P. e0307651 - e0307651
Published: Aug. 26, 2024
Colorectal
cancer
(CRC)
ranks
as
the
third
most
prevalent
globally
and
stands
second
principal
contributor
to
cancer-related
fatalities.
Recently,
emerging
research
has
emphasized
role
of
pan
apoptosis
(PANoptosis)
in
tumor
development
anti-tumor
therapy.
In
course
this
investigation,
we
meticulously
identified
conducted
a
correlation
analysis
between
differentially
expressed
genes
associated
with
PANoptosis
CRC
(CPAN_DEGs)
proportion
immune
cells.
Subsequently,
formulated
prognostic
score
based
on
CPAN_DEGs.
Further
our
revealed
noteworthy
reduction
UNC5D
mRNA
expression
within
HCT116,
HT29
SW480
cells,
validated
by
qRT-PCR
assay.
Furthermore,
scrutinizing
TCGA
database
unveiled
distinctive
trend
wherein
individuals
low
exhibited
significantly
reduced
overall
survival
compared
their
counterparts
high
levels.
The
drug
susceptibility
was
further
performed,
which
showed
that
corassociated
sensitivity
6-Thioguanine.
outcomes
investigation
underscore
mechanisms
influences
dysregulation
well
outcome
CRC.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 30, 2023
Abstract
Background
Cuproptosis
is
a
novel
mode
of
cell
death,
which
strongly
related
to
energy
metabolism
in
mitochondria
and
regulated
by
protein
lipoylation.
Currently,
the
molecular
mechanisms
cuproptosis-related
genes
(CRGs)
involved
systemic
lupus
erythematosus
(SLE)
largely
remained
unclear,
our
study
aimed
explore
cuproptosis
CRGs
SLE.
Methods
Bulk
RNA-seq
datasets
were
collected
display
expressions
peripheral
blood
mononuclear
cells
(PBMCs)
SLE
healthy
individuals,
then
ROC
analysis
was
used
establish
diagnostic
models
CRGs.
Next,
immune
infiltration
analyses
applied
reveal
difference
LIAS-low
LIAS-high
group.
Additionally,
WGCNA
performed
find
gene
modules
significantly
corelated
with
LIAS
expression
level.
We
also
functional
enrichment
for
LIAS-related
determine
potential
pathways
development
Finally,
scRNA-seq
dataset
cluster
subsets,
activated
pathways,
cell-cell
interactions
cells.
Result
found
CDKN2A
increased
decreased
patients
compared
individuals.
The
AUC
score
showed
that
had
great
value
than
other
results
proportion
diverse
samples.
sets
level
dephosphorylation
JAK1
SHP1,
phosphorylation
STAT2,
cytokine
signaling
system,
interferon-alpha
beta,
inhibition
JAK
kinase
activity
SOCS1/3
so
on.
communication
CCL-
(CCL5
+
CCR1)
ANNEXIN-
(ANXA1
FPR1)
might
play
an
essential
role
network
between
Conclusions
Above
findings
inferred
LIAS-mediated
involve
comprehensive
cellular
mechanism
cause
occurrence
