Enhanced lysosomal escape of cell penetrating peptide-functionalized metal–organic frameworks for co-delivery of survivin siRNA and oridonin DOI Creative Commons
Mengru Cai,

Yu Yao,

Dongge Yin

et al.

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 646, P. 370 - 380

Published: April 28, 2023

In recent years, small interfering RNA (siRNA) has been widely used in the treatment of human diseases, especially tumors, and shown great appeal. However, clinical application siRNA faces several challenges. Insufficient efficacy, poor bioavailability, stability, lack responsiveness to a single therapy are main problems affecting tumor therapy. Here, we designed cell-penetrating peptide (CPP)-modified metal organic framework nanoplatform (named PEG-CPP33@ORI@survivin siRNA@ZIF-90, PEG-CPP33@NPs) for targeted co-delivery oridonin (ORI), natural anti-tumor active ingredient) survivin vivo. This can improve stability bioavailability efficacy monotherapy. The high drug-loading capacity pH-sensitive properties zeolite imidazolides endowed PEG-CPP33@NPs with lysosomal escape abilities. Polyethylene glycol (PEG)-conjugated CPP (PEG-CPP33) coating significantly improved uptake vitro results showed that ORI greatly enhanced effect PEG-CPP33@NPs, demonstrating synergistic between siRNA. summary, novel nanobiological platform loaded presented herein advantages cancer therapy, provides an attractive strategy chemotherapy gene

Language: Английский

Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy DOI Creative Commons
Jie Yang, Dihua Dai, Xi Zhang

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 13(1), P. 295 - 323

Published: Dec. 19, 2022

Cancer remains a severe threat to human health. To date, although various therapeutic methods, including radiotherapy (RT), chemotherapy, chemodynamic therapy (CDT), phototherapy, starvation therapy, and immunotherapy, have entered new stage of rapid progress in cancer theranostics, their limited effect significant side effects need be considered carefully. With the development nanotechnology, marriage nanomaterials methods provides practical possibility improve deficiencies therapy. Notably, metal-organic frameworks (MOFs) composed ions/clusters bridging ligands through coordination bonds been widely applied deal with drawbacks different such as effects, low stability, poor efficacy, owing controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, good biocompatibility. This review summarizes recent advanced developments achievements multifunctional MOF-based nanoplatforms for single RT, CDT, phototherapy (photodynamic photothermal therapy), combination methods. Moreover, prospects challenges used tumor are also discussed.

Language: Английский

Citations

140
A new 3D 8-connected Cd(ii) MOF as a potent photocatalyst for oxytetracycline antibiotic degradation DOI
Xiu‐Yan Dong, Yuyan Li, Duqingcuo Li

et al.

CrystEngComm, Journal Year: 2022, Volume and Issue: 24(39), P. 6933 - 6943

Published: Jan. 1, 2022

1 exhibits the best photocatalytic decomposition efficiency towards antibiotic OXY. The plausible mechanism has been explained with help of density states calculations and Hirshfeld surface analysis.

Language: Английский

Citations

128
Recent advances in bimetallic metal–organic frameworks (BMOFs): synthesis, applications and challenges DOI
Si Liu,

Yuzhi Qiu,

Yafen Liu

et al.

New Journal of Chemistry, Journal Year: 2022, Volume and Issue: 46(29), P. 13818 - 13837

Published: Jan. 1, 2022

An overview on the recent progress in bimetallic MOFs regarding their design strategies, syntheses and multifarious applications.

Language: Английский

Citations

110
Recent advances in Ti-based MOFs in biomedical applications DOI
Jinyi Chen, Fan Cheng,

Dongwen Luo

et al.

Dalton Transactions, Journal Year: 2022, Volume and Issue: 51(39), P. 14817 - 14832

Published: Jan. 1, 2022

This study reviews the development of titanium-based MOFs in therapeutic areas antibacterial therapy, tumor anti-inflammatory and bone injury therapy.

Language: Английский

Citations

99
Current Challenges and Opportunities of Photodynamic Therapy against Cancer DOI Creative Commons

Ruben V. Huis in ‘t Veld,

Jeroen Heuts, Sen Ma

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 330 - 330

Published: Jan. 18, 2023

BACKGROUND: Photodynamic therapy (PDT) is an established, minimally invasive treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are generated that ultimately induce cell death and disruption the tumor area. Moreover, PDT can result in damage to vasculature release and/or exposure damage-associated molecular patterns (DAMPs) may initiate antitumor immune response. However, there currently several challenges limit its widespread application certain indications clinic. METHODS: A literature study was conducted comprehensively discuss these identify opportunities improvement. RESULTS: The most notable improve them have been identified discussed. CONCLUSIONS: recent efforts current promising, notably those focus on enhancing responses initiated by treatment. improvements has potential enhance efficacy thereby broadening

Language: Английский

Citations

96
Metal–organic frameworks (MOFs) as apt luminescent probes for the detection of biochemical analytes DOI

Dongwen Luo,

Jie‐Feng Huang,

Yanhong Jian

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(29), P. 6802 - 6822

Published: Jan. 1, 2023

This article reviews the recent developments in use of MOF materials as probes and biosensing platforms for diverse chemicals (H 2 O , metal ions, H S, GSH, nucleic acids) biological cells.

Language: Английский

Citations

91
Recent Advances of Silver-Based Coordination Polymers on Antibacterial Applications DOI Creative Commons
Wenfeng Zhang,

Gaomin Ye,

Donghui Liao

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(21), P. 7166 - 7166

Published: Oct. 23, 2022

With the continuous evolution of bacteria and constant use traditional antibiotics, emergence drug-resistant super viruses has attracted worldwide attention. Antimicrobial therapy become most popular important research field at present. Coordination Polymer (CP) and/or metal-organic framework (MOF) platforms have advantages a high biocompatibility, biodegradability, non-toxicity, great antibacterial potential been widely used in treatment. This paper reviewed mechanism effect three typical MOFs (pure Ag-MOFs, hybrid Ag-containing-polymer @MOFs) silver-based coordination polymers. At same time, existing shortcomings future views are briefly discussed. The study on efficacy Ag-MOFs can provide better basis for its clinical application and, meanwhile, open up novel strategy preparation more advanced Ag-contained materials with characteristics.

Language: Английский

Citations

84
Current and promising applications of Hf(iv)-based MOFs in clinical cancer therapy DOI

Xuelin Chen,

Minmin Li,

Mingzi Lin

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(25), P. 5693 - 5714

Published: Jan. 1, 2023

Cancer is one of the greatest challenges in medical science today as it poses a serious threat to human life. In view this, myriad therapeutic strategies are being developed for treatment cancer. Despite use various approaches, they still insufficient The rapid advancement nanotechnology currently offers exciting possibilities creation novel cancer therapy approaches. Metal organic frameworks (MOFs) emerging multifunctional nanomaterials that find prospective applications biomedical field owing their porosity, large specific surface area, and diversified structures. Amongst varied categories MOFs, Hf(IV)-based MOFs have been since 2012 finding new hence this class gaining immense attention amongst material biomaterial chemists. Most importantly, Hf(IV)-MOFs comprising high Z-Hf metal content may be capable offering options therapy, nonlinear optics, fluorescent sensors, photoresponsive devices. review, progress using radiotherapy, chemotherapy, immunotherapy, phototherapeutic techniques, or combination two more these techniques explored. This review also provides insight regarding current limitations future prospects therapy.

Language: Английский

Citations

79
A metal-organic framework-based immunomodulatory nanoplatform for anti-atherosclerosis treatment DOI

Zhijue Xu,

Zhaoyu Wu, Sheng Huang

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 615 - 625

Published: Jan. 23, 2023

Language: Английский

Citations

78
Current status and prospects of MOFs in controlled delivery of Pt anticancer drugs DOI
Jinyi Chen, Zhixin Zhang, Jiaxin Ma

et al.

Dalton Transactions, Journal Year: 2023, Volume and Issue: 52(19), P. 6226 - 6238

Published: Jan. 1, 2023

This review focuses on the application of platinum as an anticancer drug and MOF materials loading species; prospect for its future development is also discussed.

Language: Английский

Citations

75