Small,
Journal Year:
2023,
Volume and Issue:
20(17)
Published: Dec. 21, 2023
Abstract
The
clinical
application
of
oncology
therapy
is
hampered
by
high
glutathione
concentrations,
hypoxia,
and
inefficient
activation
cell
death
mechanisms
in
cancer
cells.
In
this
study,
Fe
Mo
bimetallic
sulfide
nanomaterial
(FeS
2
@MoS
)
based
on
metal‐organic
framework
structure
rationally
prepared
with
peroxidase
(POD)‐,
catalase
(CAT)‐,
superoxide
dismutase
(SOD)‐like
activities
depletion
ability,
which
can
confer
versatility
for
treating
tumors
mending
wounds.
the
lesion
area,
FeS
SOD‐like
activity
facilitate
transformation
anions
(O
−
to
hydrogen
peroxide
(H
O
),
then
resulting
H
serves
as
a
substrate
Fenton
reaction
FMS
produce
highly
toxic
hydroxyl
radicals
(
∙
OH).
Simultaneously,
has
an
ability
deplete
(GSH)
catalyze
decomposition
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
curb
regeneration
GSH
from
source.
Thus
it
realize
effective
tumor
elimination
through
synergistic
apoptosis‐ferroptosis
strategy.
Based
alteration
system,
free
radical
production,
alleviation
hypoxia
microenvironment,
NPS
not
only
significantly
inhibit
vivo
vitro,
but
also
multidrug‐resistant
bacteria
hasten
wound
healing.
It
may
open
door
development
cascade
nanoplatforms
treatment
overcoming
infection.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(29), P. 6802 - 6822
Published: Jan. 1, 2023
This
article
reviews
the
recent
developments
in
use
of
MOF
materials
as
probes
and
biosensing
platforms
for
diverse
chemicals
(H
2
O
,
metal
ions,
H
S,
GSH,
nucleic
acids)
biological
cells.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(25), P. 5693 - 5714
Published: Jan. 1, 2023
Cancer
is
one
of
the
greatest
challenges
in
medical
science
today
as
it
poses
a
serious
threat
to
human
life.
In
view
this,
myriad
therapeutic
strategies
are
being
developed
for
treatment
cancer.
Despite
use
various
approaches,
they
still
insufficient
The
rapid
advancement
nanotechnology
currently
offers
exciting
possibilities
creation
novel
cancer
therapy
approaches.
Metal
organic
frameworks
(MOFs)
emerging
multifunctional
nanomaterials
that
find
prospective
applications
biomedical
field
owing
their
porosity,
large
specific
surface
area,
and
diversified
structures.
Amongst
varied
categories
MOFs,
Hf(IV)-based
MOFs
have
been
since
2012
finding
new
hence
this
class
gaining
immense
attention
amongst
material
biomaterial
chemists.
Most
importantly,
Hf(IV)-MOFs
comprising
high
Z-Hf
metal
content
may
be
capable
offering
options
therapy,
nonlinear
optics,
fluorescent
sensors,
photoresponsive
devices.
review,
progress
using
radiotherapy,
chemotherapy,
immunotherapy,
phototherapeutic
techniques,
or
combination
two
more
these
techniques
explored.
This
review
also
provides
insight
regarding
current
limitations
future
prospects
therapy.
Dalton Transactions,
Journal Year:
2023,
Volume and Issue:
52(19), P. 6226 - 6238
Published: Jan. 1, 2023
This
review
focuses
on
the
application
of
platinum
as
an
anticancer
drug
and
MOF
materials
loading
species;
prospect
for
its
future
development
is
also
discussed.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(28)
Published: Aug. 2, 2023
Critical
limb
ischemia,
the
final
course
of
peripheral
artery
disease,
is
characterized
by
an
insufficient
supply
blood
flow
and
excessive
oxidative
stress.
H2
S
molecular
therapy
possesses
huge
potential
for
accelerating
revascularization
scavenging
intracellular
reactive
oxygen
species
(ROS).
Moreover,
it
found
that
BMP6
most
significantly
up-expressed
secreted
protein-related
gene
in
HUVECs
treated
with
GYY4137,
a
donor,
based
on
transcriptome
analysis.
Herein,
UIO-66-NH2
@GYY4137@BMP6
co-delivery
nanoplatform
to
strengthen
therapeutic
effects
ischemia
developed.
The
established
exerts
its
proangiogenic
anti-oxidation
functions
regulating
key
pathways.
underlying
mechanisms
dual-loading
system
lie
upregulation
phosphorylated
YAP/TAZ
Jun
promote
proliferation
downregulation
p53/p21
scavenge
ROS.
Meanwhile,
laser-doppler
perfusion
imaging
(LDPI),
injury
severity
evaluation,
histological
analysis
confirm
excellent
vivo.
This
work
may
shed
light
treatment
critical
YAP,
Jun,
p53
signaling
pathways
gas-protein
synergistic
therapy.
Small,
Journal Year:
2024,
Volume and Issue:
20(30)
Published: March 7, 2024
Abstract
In
recent
years,
there
has
been
growing
interest
in
developing
innovative
materials
and
therapeutic
strategies
to
enhance
wound
healing
outcomes,
especially
for
chronic
wounds
antimicrobial
resistance.
Metal–organic
frameworks
(MOFs)
represent
a
promising
class
of
next‐generation
dressings.
Their
high
surface
area,
pore
structures,
stimuli‐responsiveness,
antibacterial
properties,
biocompatibility,
potential
combination
therapies
make
them
suitable
complex
care
challenges.
MOF‐based
composites
promote
cell
proliferation,
angiogenesis,
matrix
synthesis,
acting
as
carriers
bioactive
molecules
promoting
tissue
regeneration.
They
also
have
stimuli‐responsivity,
enabling
photothermal
skin
cancer
infections.
Herein,
critical
analysis
the
current
state
research
on
MOFs
dressings
is
provided,
offering
valuable
insights
into
applications,
challenges,
future
directions
this
field.
This
literature
review
targeted
multifunctionality
nature
wound‐disease
therapy
from
different
aspects
discussed
most
advancements
made
context,
reader
will
find
how
contributed
field
yield
more
effective,
functional,
they
lead
next
generation
biomaterials
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(17), P. 10979 - 11024
Published: April 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
