Nanoarchitectonics of Copper Sulfide Nanoplating for Improvement of Computed Tomography Efficacy of Bismuth Oxide Constructs towards Drugless Theranostics DOI Creative Commons

Ruo-Yin Meng,

Hong‐Ying Xia,

Ying Zhao

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract Triple-negative breast cancer (TNBC) has emerged as one of the dreadful metastatic tumors in women due to complexity, specificity and high recurrence, resulting poor therapeutic outcomes requiring real-time monitoring for improved theranostics. Despite success efficient radiosensitizers computed tomography (CT)-based contrast agents, bismuth (Bi)-based composites suffer from colloidal stability, dose-dependent toxicity pharmacokinetic shortcomings, leading monitoring. In addition, several small molecule-based therapeutics, including nanoparticle-based delivery systems, limitations acquired multidrug resistance by cells, depriving needs. To overcome this aspect, study demonstrates fabrication drug-like/drugless nanoarchitectures based on copper sulfide-nanoplated oxide (Bi2O3@CuS, shortly BC) theranostic efficacy against TNBC. These systematically characterized BC nanocomposites exhibited pH-/near-infrared (NIR, 808 nm) light-responsive degradability toward dual modal therapies. Due band transition Cu species, designed displayed exceptional photothermal (PTT) conversion efficiency localized PTT effects. addition pH-/NIR-responsiveness, internally overexpressed glutathione (GSH)-responsiveness facilitated release Cu2+ species chemodynamic therapy (CDT)-based end, Bi3+ core could be fully hydrated acidic tumor microenvironment, GSH depletion reducing CDT-induced reactive oxygen clearance, thereby ablating tumors. The acid-responsive CuS resulted intratumoral enrichment BC, demonstrating remarkable CT imaging vivo. Together, these pH-/NIR-/GSH-responsive biodegradable realize integrated PTT/CDT/CT theranostics carcinoma.

Language: Английский

Near-Infrared-II-Activatable Self-Assembled Manganese Porphyrin-Gold Heterostructures for Photoacoustic Imaging-Guided Sonodynamic-Augmented Photothermal/Photodynamic Therapy DOI

Peijing Xu,

Changchun Wen, Cunji Gao

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 18(1), P. 713 - 727

Published: Dec. 20, 2023

Porphyrins and their derivatives are widely used as photosensitizers sonosensitizers in tumor treatment. Nevertheless, poor water solubility low chemical stability reduce singlet oxygen (1O2) yield and, consequently, photodynamic therapy (PDT) sonodynamic (SDT) efficiency. Although strategies for porphyrin molecule assembly have been developed to augment 1O2 generation, there is scope further improving PDT SDT efficiencies. Herein, we synthesized ordered manganese (SM) nanoparticles with well-defined self-assembled metalloporphyrin networks that enabled efficient energy transfer enhanced photocatalytic sonocatalytic activity production. Subsequently, Au were grown situ on the SM surface by anchoring terminal alkynyl of form plasmonic SMA heterostructures, which showed excellent near-infrared-II (NIR-II) region absorption photothermal properties, facilitated electron–hole pair separation transfer. With modification hyaluronic acid (HA), SMAH heterostructure nanocomposites exhibited good actively targeted cancer cells. Under NIR-II light ultrasound (US) irradiation, generates hyperthermia, a large amount 1O2, inducing cell damage. Both vitro vivo studies confirmed effectively suppressed growth decreasing GSH levels SDT-augmented PDT/PTT. Moreover, utilizing strong window, can achieve photoacoustic imaging-guided combined This work provides paradigm enhancing metalloporphyrins improve synergistic therapeutic effect SDT/PDT/PTT.

Language: Английский

Citations

58
Construction of 2D/2D Ti3C2T MXene/CdS heterojunction with photothermal effect for efficient photocatalytic hydrogen production DOI
Taiyu Huang, Zhi Yang, Shenyuan Yang

et al.

Journal of Material Science and Technology, Journal Year: 2023, Volume and Issue: 171, P. 1 - 9

Published: Aug. 3, 2023

Language: Английский

Citations

46
Sulfur Vacancy‐Rich Bi2S3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria DOI
Dong Mo, Meng Pan, Wen Chen

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)

Published: Feb. 23, 2024

Abstract Antibacterial photocatalytic therapy (APCT) is one of the most promising non‐antibiotic treatment strategies for biofilm‐infected wounds and inflammation caused by drug‐resistant bacteria. However, it still faces issues such as inadequate single antibacterial capacity lack antioxidant capacity. In this study, a Z‐scheme heterojunction (Bi 2 S 3‐X @PDA) designed using polydopamine (PDA) shell firmly anchored to surface sulfur vacancy‐rich bismuth sulfide nanorods NRs). Under near‐infrared light hydrogen peroxide, Bi @PDA significantly improves efficiency reactive oxygen species generation shows nearly 100% broad‐spectrum effect against multiple bacterial strains biofilms in vitro. Interestingly, activity PDA remarkably downregulates expression pro‐inflammatory factors promotes macrophage reprogramming toward proregenerative M2 phenotype. mouse wound model methicillin‐resistant Staphylococcus aureus biofilm infection, effectively eliminates through APCT/mild photothermal therapy, while reducing normal tissues regulating immune microenvironment, thereby promoting rapid healing. Overall, light‐controlled strategy, which provides both anti‐inflammatory functions, reliable tool combating infection

Language: Английский

Citations

28
Biomimetic Gold Nanorods‐Manganese Porphyrins with Surface‐Enhanced Raman Scattering Effect for Photoacoustic Imaging‐Guided Photothermal/Photodynamic Therapy DOI
Huihui Liu, Cunji Gao,

Peijing Xu

et al.

Small, Journal Year: 2024, Volume and Issue: 20(42)

Published: June 20, 2024

Abstract Surface‐enhanced Raman scattering (SERS) imaging integrating photothermal and photodynamic therapy (PTT/PDT) is a promising approach for achieving accurate diagnosis effective treatment of cancers. However, most available reporters show multiple signals in the fingerprint region, which overlap with background from cellular biomolecules. Herein, 4T1 cell membrane‐enveloped gold nanorods‐manganese porphyrins system (GMCMs) designed successfully fabricated as biomimetic theranostic nanoplatform. Manganese are adsorbed on surface Au nanorods via terminal alkynyl group. Cell membrane encapsulation protects manganese falling off nanorods. The GMCMs confirm specific homologous targeting to cells good dispersibility, excellent photoacoustic (PA) properties, preferable 1 O 2 generation performance. exhibit distinct SERS silent region without endogenous biomolecule interference both vitro vivo. ions could not only quench fluorescence enhance effect but also deplete GSH increase yield. Both vivo studies demonstrate that effectively eradicate tumors through SERS/PA imaging‐guided PTT/PDT. This study provides feasible strategy augmenting effects group GSH‐depletion PTT/PDT efficacy.

Language: Английский

Citations

18
Multi-pathway oxidative stress amplification via controllably targeted nanomaterials for photoimmunotherapy of tumors DOI Creative Commons
Hang Li,

Yunheng Liu,

Xiaokang Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 22, 2025

Photoimmunotherapy, which combines phototherapy with immunotherapy, exhibits significantly improved therapeutic effects compared mono-treatment regimens. However, its use is associated drawbacks, such as insufficient reactive oxygen species (ROS) production and uneven photosensitizer distribution. To address these issues, we developed a controllable, targeted nanosystem that enhances oxidative stress through multiple pathways, achieving synergistic photothermal, photodynamic, immunotherapy for tumor treatment. These nanoparticles (D/I@HST NPs) accurately target overexpressed transferrin receptors (TfRs) on the surface of cells surface-modified (Tf). After endocytosis, D/I@HST NPs generate ROS under 808-nm laser irradiation, breaking ROS-responsive crosslinking agent increasing drug release utilization. Tf also carries Fe3+, reduced to Fe2+ by iron reductase in acidic microenvironment (TME). Consequently, endoperoxide bridge structure dihydroartemisinin cleaved, causing additional generation. Furthermore, released IR-780 exerts both photodynamic photothermal effects, enhancing cell death. This multi-pathway amplification effect can trigger immunogenic death tumors, promoting relevant antigens damage-associated molecular patterns, thereby dendritic maturation sensitivity immunotherapy. Mature transmit signals T cells, infiltration activation, facilitating growth inhibition suppression lung metastasis. myeloid-derived suppressor decreases after In summary, this stress-amplified effectively inhibits reverses immunosuppressive microenvironment, provides new insights into combined phototherapy.

Language: Английский

Citations

3
Engineering of Schottky heterojunction in Ru@Bi2S3/Nb2C MXene based on work function with enhanced carrier separation for promoted sterilization DOI

Jiafeng Xi,

Xiaojuan Liu,

Liang Zhang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 473, P. 145169 - 145169

Published: Aug. 3, 2023

Language: Английский

Citations

35
Polysaccharide-based gold nanomaterials: Synthesis mechanism, polysaccharide structure-effect, and anticancer activity DOI Creative Commons
Haoqiang Liu, Minwei Zhang,

Fanxing Meng

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 321, P. 121284 - 121284

Published: Aug. 14, 2023

Polysaccharide-based gold nanomaterials have attracted great interest in biomedical fields such as cancer therapy and immunomodulation due to their prolonged residence time vivo enhanced immune response. This review aims provide an up-to-date comprehensive summary of polysaccharide-based Au NMs synthesis, including mechanisms, polysaccharide structure-effects, anticancer activity. Firstly, research progress on the synthesis mechanism was addressed, which included three types based variety polysaccharides reaction environment: breaking glycosidic bonds via (III) or base-mediated production highly reduced intermediates, reduction free hydroxyl groups molecules, amino molecules. Then, potential effects structure characteristics (molecular weight, composition monosaccharides, functional groups, bonds, chain conformation) conditions (the temperature, time, pH, concentration precursor polysaccharides) size shape were explored. Finally, current status summarized before reaching our conclusions perspectives.

Language: Английский

Citations

23
Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment DOI
Min Zhang, Dandan Sun, Hui Huang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Language: Английский

Citations

10
pH-Responsive injectable self-healing hydrogels loading Au nanoparticles-decorated bimetallic organic frameworks for synergistic sonodynamic-chemodynamic-starvation-chemo therapy of cancer DOI

Sicheng Xu,

Hanyan Zhang,

Zhiyi Qian

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 675, P. 746 - 760

Published: July 9, 2024

Language: Английский

Citations

9
Natural supramolecular photosensitizer with in situ switchable photothermal/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy DOI Creative Commons

Shiyao Fu,

Jianjun Cheng, Hua Zhang

et al.

Acta Materia Medica, Journal Year: 2025, Volume and Issue: 4(2)

Published: Jan. 1, 2025

Treatment of cancer can be challenging, because the disease’s intricate and varied nature. Consequently, developing nanomedicines with multimodal therapeutic capabilities for precise tumor therapy holds substantial promise in advancing treatment. Herein, a nanoplatform strategy involving supramolecular photosensitizers (ETSCe6 NPs) chelated metal ions (Au Bi) was found to induce shift microenvironment responsiveness from photothermal photodynamic therapy, thus facilitating visualization diagnosis Self-assembly enhanced through aggregation-caused quenching. Moreover, glutathione triggered disulfide bond cleavage, consequently Ergosterol (ET) Chlorin e6 release. Therefore, chemotherapy achieved synergistic anticancer effects. Ce6 cavities were also used chelate high valence Au Bi computed tomography. The ETSCe6@Au, NPs demonstrated remarkable efficacy vitro vivo , achieving complete elimination after This integrated approach combining imaging, chemotherapy, photodynamic, therapies has clinical applications, may provide an innovative intelligent promising prospects.

Language: Английский

Citations

1