Progress and challenges in the translation of cancer nanomedicines

Current Opinion in Biotechnology, Journal Year: 2023, Volume and Issue: 85, P. 103045 - 103045

Published: Dec. 14, 2023

Language: Английский

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Bioinspired Tumor Calcification‐Guided Early Diagnosis and Eradication of Hepatocellular Carcinoma

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Jan. 8, 2024

Abstract Tumor calcification is found to be associated with the benign prognostic, and which shows considerable promise as a somewhat predictive index of tumor response clinically. However, still missing area in clinical cancer treatment. A specific strategy proposed for inducing through synergy calcium peroxide (CaO 2 )‐based microspheres transcatheter arterial embolization treatment hepatocellular carcinoma (HCC). The persistent stress situ specifically leads powerful calcioptosis, resulting diffuse high‐density shadow on computed tomography that enables clear localization vivo site partial delineation margins an orthotopic HCC rabbit model. This osmotic can facilitate diagnosis, great significance differentiating during early follow‐up periods. Proteome phosphoproteome analysis identify calreticulin (CALR) crucial target protein involved calcioptosis. Further fluorescence molecular imaging also indicates CALR used prodromal marker predict at earlier stage different preclinical rodent models. These findings suggest upregulated association calcification, may broadly useful quick visualization response.

Language: Английский

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Nanotechnology‐based CRISPR/Cas9 delivery system for genome editing in cancer treatment

MedComm – Biomaterials and Applications, Journal Year: 2024, Volume and Issue: 3(1)

Published: Jan. 14, 2024

Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (CRISPR/Cas9) systems initiate a revolution in genome editing, which have significant potential for treating cancer. A amount of research has been conducted regarding genetic modification using CRISPR/Cas9 systems, and 33 clinical trials ex vivo or gene editing techniques carried out to treat Despite its advantages, the main obstacle convert technology into applications is safe efficient transport material owing various extra‐ intracellular biological hurdles. We outline characteristics three forms cargos, plasmids, mRNA/sgRNA, ribonucleoprotein (RNP) complexes this review. recent nanotechnology‐based delivery these categories cancer are then reviewed. In end, we prerequisites effective secure contexts discuss challenges with current nanocarriers. This review offers thorough overview nano‐delivery system treatment cancer, serving as resource design building offering fresh perspectives on tumors.

Language: Английский

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Multitargeted molecular docking and dynamics simulation of thymol-based chalcones against cancer protein markers: Synthesis, characterization, and computational study

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1317, P. 139116 - 139116

Published: June 27, 2024

Language: Английский

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Hydrophilic biomaterials: From crosslinked and self-assembled hydrogels to polymer-drug conjugates and drug-free macromolecular therapeutics

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 1 - 22

Published: May 17, 2024

Language: Английский

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Optimizing Surface Maleimide/cRGD Ratios Enhances Targeting Efficiency of cRGD-Functionalized Nanomedicines

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Thiol-maleimide (MI) chemistry is a cornerstone of bioconjugation strategies, particularly in the development drug delivery systems. The cyclic arginine-glycine-aspartic acid (cRGD) peptide, recognized for its ability to target integrin α

Language: Английский

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3D Printing in Development of Nanomedicines

Nanomaterials, Journal Year: 2021, Volume and Issue: 11(2), P. 420 - 420

Published: Feb. 7, 2021

Three-dimensional (3D) printing is gaining numerous advances in manufacturing approaches both at macro- and nanoscales. being explored for various biomedical applications fabrication of nanomedicines using additive techniques, shows promising potential fulfilling the need patient-centric personalized treatment. Initial reports attributed this to availability novel natural biomaterials precisely engineered polymeric materials, which could be fabricated into exclusive 3D printed nanomaterials as nanomedicines. Nanomedicine defined application nanotechnology designing different medicinal applications, including diagnosis, treatment, monitoring, prevention, control diseases. also showing great impact design development precision medicine. In contrast “one-size-fits-all” criterion conventional medicine system, or medicines consider differences traits, pharmacokinetics genetics patients, have shown improved results over last few years, much literature has been published on nanomedicine. This article deals with progress made tailor-made nanomedicine technology.

Language: Английский

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Selective transferrin coating as a facile strategy to fabricate BBB-permeable and targeted vesicles for potent RNAi therapy of brain metastatic breast cancer in vivo

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 337, P. 521 - 529

Published: Aug. 2, 2021

Language: Английский

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Recent advances in tumor microenvironment-targeted nanomedicine delivery approaches to overcome limitations of immune checkpoint blockade-based immunotherapy

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 332, P. 109 - 126

Published: Feb. 9, 2021

Language: Английский

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Facile fabrication of robust, hyaluronic acid-surfaced and disulfide-crosslinked PLGA nanoparticles for tumor-targeted and reduction-triggered release of docetaxel

Acta Biomaterialia, Journal Year: 2021, Volume and Issue: 125, P. 280 - 289

Published: March 7, 2021

Language: Английский

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