International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 649, P. 123669 - 123669
Published: Dec. 4, 2023
Language: Английский
Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 392, P. 123472 - 123472
Published: Nov. 2, 2023
Language: Английский
Citations
77
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(4)
Published: Nov. 9, 2023
Diabetic wounds are more likely to develop into complex and severe chronic wounds. The objective of this study is assess a reactive oxygen species (ROS)-responsive multifunctional injectable hydrogel for the purpose diabetic wound healing. A (HA@Cur@Ag) successfully synthesized with dual antioxidant, antibacterial, anti-inflammatory properties by crosslinking thiol hyaluronic acid (SH-HA) disulfide-bonded hyperbranched polyethylene glycol (HB-PBHE) through Michael addition; while, incorporating curcumin liposomes silver nanoparticles (AgNPs). HA@Cur@Ag exhibits favorable biocompatibility, degradability, injectivity. outcomes in vitro vivo experiments demonstrate that can effectively be loaded release liposomes, as well ions, thereby facilitating healing multiple mechanisms, including ROS scavenging, bactericidal activity, effects, promotion angiogenesis. Transcriptome sequencing reveals suppresses activation tumour necrosis factor (TNF)/nuclear κB (NF-κB) pathway ameliorate oxidative stress inflammation These findings suggest ROS-responsive hydrogel, which possesses ability precisely coordinate integrate intricate biological molecular processes involved healing, notable potential expediting
Language: Английский
Citations
50
Biosensors, Journal Year: 2022, Volume and Issue: 12(8), P. 617 - 617
Published: Aug. 8, 2022
Immunotherapy is one of the four pillars cancer treatment that has recently emerged as a beacon hope for patients. Certain immunotherapies, example, immune checkpoint inhibitor therapy, monoclonal antibody therapy and chimeric antigen T-cell have garnered extensive interest in response to their exceptional properties activate system respond cells, inhibiting progression. In era rapid development, dostarlimab, an anti-programmed cell death protein (PD-1) mesmerized medical profession by showing complete (100%) cure patients with colorectal cancer. Not only this, results obtained from clinical trials revealed no major side effects any participants study. Dostarlimab also shown promising endometrial cancer, ovarian melanoma, head neck breast therapy. This review focuses upon action immunotherapy, extensively emphasizing miraculous T-cells treatment. Based on we discuss ongoing combination immunotherapies enlighten future clinicians researchers about dostarlimab against various cancers.
Language: Английский
Citations
44
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)
Published: March 3, 2024
Abstract Curcumin, a natural bioactive polyphenol with diverse molecular targets, is well known for its anti‐oxidation and anti‐inflammatory potential. However, curcumin exhibits low solubility (<1 µg mL −1 ), poor tissue‐targeting ability, rapid oxidative degradation, resulting in bioavailability stability inflammatory therapy. Here, poly(diselenide‐oxalate‐curcumin) nanoparticle (SeOC‐NP) dual‐reactive oxygen species (ROS) sensitive chemical moieties (diselenide peroxalate ester bonds) fabricated by one‐step synthetic strategy. The results confirmed that dual‐ROS endowed SeOC‐NP the ability of targeted delivery significantly suppress degradation high‐efficiency In detail, amount SeOC about 4‐fold lower than free an microenvironment. As result, enhanced antioxidant activity efficacy vitro analysis scavenging intracellular ROS suppressing secretion nitric oxide pro‐inflammatory cytokines. mouse colitis models, orally administered can remarkably alleviate symptoms IBD maintain homeostasis gut microbiota. This work provided simple effective strategy to fabricate ROS‐responsive micellar enhance oxidation medicine precise therapeutic inflammation.
Language: Английский
Citations
11
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Sept. 30, 2024
Language: Английский
Citations
10
Matter, Journal Year: 2024, Volume and Issue: 7(3), P. 794 - 825
Published: Jan. 15, 2024
Language: Английский
Citations
9
Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 40(7-9), P. 564 - 593
Published: Jan. 22, 2024
Significance: Currently, a large amount of evidence beneficial effects diets enriched with polyphenols on various aspects health has been accumulated. These phytochemicals have geroprotective potential slowing down the pathological processes associated aging and ensuring longevity. In this study, comprehensive analysis was conducted to determine adherence individual geroprotector criteria. Data from experimental models, clinical trials, epidemiological studies were analyzed. Recent Advances: Sixty-two described increase life span improve biomarkers in animal models. They act via evolutionarily conserved molecular mechanisms, including hormesis maintenance redox homeostasis, epigenetic regulation, response cellular damage, metabolic control, anti-inflammatory senolytic activity. Epidemiological suggest that certain for prevention treatment diseases, cancer, disorders, cardiovascular conditions humans. Critical Issues: Among reviewed phytochemicals, chlorogenic acid, quercetin, epicatechin, genistein, resveratrol, curcumin identified as compounds highest potential. However, there is lack unambiguous information effectiveness safety increasing span, preventing treating aging-associated diseases Future Directions: Further research needed fully understand considering their long-term consumption, modification bioavailability, complex interactions between different groups other well individuals status. Antioxid. Redox Signal. 40, 564–593. Color images are available online.
Language: Английский
Citations
7
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 20, 2024
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease of yet undetermined etiology that accompanied by significant oxidative stress, inflammatory responses, and damage to joint tissues. In this study, we designed chondroitin sulfate (CS)-modified tragacanth gum–gelatin composite nanocapsules (CS-Cur-TGNCs) loaded with curcumin nanocrystals (Cur-NCs), which rely on the ability CS target CD44 accumulate drugs in inflamed joints. Cur was encapsulated form into (TGNCs) using an inborn microcrystallization method, produced CS-Cur-TGNCs particle size approximately 80 ± 11.54 nm drug loading capacity 54.18 5.17%. vitro release assay, showed MMP-2-responsive properties. During treatment RA, significantly inhibited promoted polarization M2-type macrophages M1-type macrophages, decreased expression factors (TNF-α, IL-1β, IL-6). addition, it also exerted excellent anti-inflammatory effects, alleviated swelling joints during gouty (GA). Therefore, CS-Cur-TGNCs, as novel delivery system, could lead new ideas for clinical therapeutic regimens RA GA. Graphical
Language: Английский
Citations
7
FEBS Journal, Journal Year: 2024, Volume and Issue: unknown
Published: July 31, 2024
Transforming growth factor‐β (TGF‐β) plays a complex role in lung cancer pathophysiology, initially acting as tumor suppressor by inhibiting early‐stage growth. However, its evolves the advanced stages of disease, where it contributes to progression not directly promoting cell proliferation but enhancing epithelial–mesenchymal transition (EMT) and creating conducive microenvironment. While EMT is typically associated with enhanced migratory invasive capabilities rather than per se , TGF‐β's influence on this process facilitates dynamics metastasis. Additionally, TGF‐β impacts microenvironment interacting immune cells, influenced genetic epigenetic changes within cells. This interaction highlights evasion chemoresistance, further complicating therapy. review provides critical overview recent findings involvement cancer, contribution modulation response. Despite considerable challenges encountered clinical trials development new treatments targeting pathway, necessity for continued, in‐depth investigation into roles TGF‐β. A deeper comprehension these may lead novel, targeted therapies cancer. intricate behavior signaling tumors previous challenges, research could yield innovative treatment strategies.
Language: Английский
Citations
7
Small Methods, Journal Year: 2024, Volume and Issue: unknown
Published: April 5, 2024
Abstract Intracerebral hemorrhage (ICH) represents one of the most severe subtypes stroke. Due to complexity brain injury mechanisms following ICH, there are currently no effective treatments significantly improve patient functional outcomes. Curcumin, as a potential therapeutic agent for is limited by its poor water solubility and oral bioavailability. In this study, mPEG‐PCL used encapsulate curcumin, forming curcumin nanoparticles, utilized intranasal administration route directly deliver nanoparticles from nasal cavity brain. By inhibiting pro‐inflammatory neuroinflammation microglia ICH in mice, reprogramming toward an anti‐inflammatory function, consequently reducing neuronal inflammatory death hematoma volume, approach improved blood‐brain barrier damage mice promoted recovery neurological function post‐stroke. This study offers promising strategy mediate neuroinflammatory microenvironments.
Language: Английский
Citations
6