Viruses,
Journal Year:
2023,
Volume and Issue:
15(3), P. 596 - 596
Published: Feb. 21, 2023
More
than
600
million
people
worldwide
have
been
infected
with
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
resulting
in
the
pandemic
of
disease
2019
(COVID-19).
In
particular,
new
waves
COVID-19
caused
by
emerging
SARS-CoV-2
variants
pose
health
risks
to
global
population.
Nanotechnology
has
developed
excellent
solutions
combat
virus
pandemic,
such
as
ACE2-based
nanodecoys,
nanobodies,
nanovaccines,
and
drug
nanocarriers.
Lessons
learned
strategies
during
this
battle
against
may
also
serve
inspiration
for
developing
nanotechnology-based
other
infectious
diseases
their
future.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(17)
Published: April 20, 2023
Extracellular
vesicles
(EVs)
are
transport
secreted
by
living
cells
and
released
into
the
extracellular
environment.
Recent
studies
have
shown
that
EVs
serve
as
"messengers"
in
intercellular
inter-organismal
communication,
both
normal
pathological
processes.
EVs,
natural
nanocarriers,
can
deliver
bioactivators
therapy
with
their
endogenous
properties.
This
review
article
describes
engineering
of
sources,
isolation
method,
cargo
loading,
boosting
approach,
adjustable
targeting
EVs.
Furthermore,
summarizes
recent
progress
made
EV-based
delivery
systems
applications,
including
cancer,
cardiovascular
diseases,
liver,
kidney,
nervous
system
COVID-19
emphasizes
obstacles
challenges
therapies
possible
strategies.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(33)
Published: May 6, 2023
Extracellular
vesicle
(EV)-based
therapies
have
emerged
as
a
promising
means
in
regenerative
medicine.
However,
the
conventional
EV
therapy
strategy
displays
some
limitations,
such
inefficient
production
and
lack
of
tissue-specific
repair
effects.
Here,
it
is
reported
that
neonatal-tissue-derived
(NEXT)
potent
for
precision
tissue
repair.
In
brief,
large
amounts
EVs
with
higher
yield/purity
can
be
readily
isolated
from
desired
tissues
less
time/cost
compared
to
cell-culture-based
method.
Moreover,
source
factors,
age
type,
affect
efficacy
tissue-derived
different
injury
models
(skin
wounds
acute
kidney
injury),
show
superior
potency
adult-tissue-derived
EVs.
Different
age-
or
tissue-type-derived
distinct
composition
(e.g.,
protein)
signatures
are
likely
due
diverse
metabolic
patterns
donor
tissues,
which
may
contribute
specific
action
modes
NEXT
types
injury.
Furthermore,
incorporated
bioactive
materials
advanced
This
study
highlights
provide
new
avenue
many
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(8), P. 7562 - 7575
Published: April 6, 2023
Integrins
expressed
on
extracellular
vesicles
(EVs)
secreted
by
various
cancers
are
reported
to
mediate
the
organotropism
of
these
EVs.
Our
previous
experiment
found
that
pancreatic
tissue
mice
with
severe
cases
acute
pancreatitis
(SAP)
overexpresses
several
integrins
and
serum
EVs
(SAP-EVs)
can
lung
injury
(ALI).
It
is
unclear
if
SAP-EV
express
promote
their
accumulation
in
ALI.
Here,
we
report
overexpress
preincubation
integrin
antagonist
peptide
HYD-1
markedly
attenuates
pulmonary
inflammation
disrupt
microvascular
endothelial
cell
(PMVEC)
barrier.
Further,
injecting
SAP
engineered
two
(ITGAM
ITGB2)
attenuate
pancreas-derived
similarly
decrease
disruption
Based
findings,
propose
ALI
patients
this
response
could
be
attenuated
administering
ITGAM
and/or
ITGB2,
which
worthy
further
study
due
lack
effective
therapies
for
SAP-induced
Small,
Journal Year:
2023,
Volume and Issue:
20(10)
Published: Nov. 2, 2023
Abstract
Diabetic
alveolar
bone
defect
(DABD)
causes
persistent
bacterial
infection,
prolonged
inflammation,
and
delayed
healing,
making
it
a
considerable
clinical
challenge.
In
this
study,
by
integrating
silver
nanoclusters
(AgNCs)
M2
macrophage‐derived
extracellular
vesicles
(M2EVs),
multifunctional
DNA‐based
hydrogel,
called
Agevgel,
is
developed
with
antibacterial,
anti‐inflammatory,
immunomodulatory,
osteogenic
properties
to
promote
DABD
rebuilding.
AgNCs
are
tightly
embedded
into
the
DNA
scaffolds
exhibit
effective
anti‐bacterial
activity,
while
immunomodulatory
M2EVs
encapsulated
within
shape‐variable
potent
anti‐inflammatory
properties.
The
results
reveal
that
Agevgel
effectively
prolongs
local
retention
time
bioactivity
of
in
vivo.
particular,
sustained
release
can
last
for
at
least
7
days
when
applying
DABD.
Compared
free
or
Aggel
(AgNCs
hydrogel)
treatments,
treatment
accelerates
healing
rate
dramatically
improves
trabecular
architecture.
Mechanistically,
plays
key
role
regulating
macrophage
polarization
promoting
expression
proliferative
factors.
summary,
provides
comprehensive
strategy
great
translational
value,
highlighting
application
hydrogels
as
an
ideal
bioscaffolds
periodontal
diseases.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(12)
Published: Jan. 15, 2024
The
Ilizarov
technique
has
been
continuously
innovated
to
utilize
tensile
stress
(TS)
for
inducing
a
bone
development-like
regenerative
process,
aiming
achieve
skeletal
elongation
and
reconstruction.
However,
it
remains
uncertain
whether
this
distraction
osteogenesis
(DO)
process
induced
by
TS
involves
the
pivotal
coupling
of
angiogenesis
mediated
type
H
endothelial
cells
(THECs).
In
study,
is
demonstrated
that
induces
formation
metaphysis-like
architecture
composed
THECs,
leading
segmental
regeneration
during
DO
process.
Mechanistically,
cell-matrix
interactions-mediated
activation
yes-associated
protein
(YAP)/transcriptional
co-activator
with
PDZ-binding
motif
(TAZ)
transcriptionally
upregulates
expression
Notch1
Delta-like
ligand
4,
which
act
as
direct
positive
regulators
THECs
phenotype,
in
marrow
(BMECs)
upon
stimulation.
Simultaneously,
Notch
intracellular
domain
enhances
YAP/TAZ
activity
upregulating
YAP
stabilizing
TAZ
protein,
thus
establishing
YAP/TAZ-Notch
circuit.
Additionally,
TS-stimulated
BMECs
secrete
exosomes
enriched
vital
molecules
feedback
pathway,
can
be
utilized
promote
defect
healing,
mimicking
therapeutic
effects
technique.
findings
advance
understanding
TS-induced
establish
foundation
innovative
biological
strategies
aimed
at
activating
THECs.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(7)
Published: Feb. 14, 2024
Extracellular
vesicle
(EV)-based
immunotherapeutics
have
emerged
as
promising
strategy
for
treating
diseases,
and
thus,
a
better
understanding
of
the
factors
that
regulate
EV
secretion
function
can
provide
insights
into
developing
advanced
therapies.
Here,
we
report
nutrient
availability,
even
changes
in
individual
components,
may
affect
biogenesis
composition
immune
cells
[e.g.,
macrophages
(Mφs)].
As
proof
concept,
EVs
from
M1-Mφ
under
glutamine-depleted
conditions
(EV
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8607 - 8607
Published: Aug. 7, 2024
The
characteristic
feature
of
chronic
peritoneal
damage
in
dialysis
(PD)
is
a
decline
ultrafiltration
capacity
associated
with
pathological
fibrosis
and
angiogenesis.
pathogenesis
attributed
to
bioincompatible
factors
PD
fluid
peritonitis.
Uremia
membrane
inflammation
that
affects
fibrosis,
neoangiogenesis,
baseline
function.
Net
volume
affected
by
capillary
surface
area,
vasculopathy,
lymphangiogenesis.
Many
inflammatory
cytokines
induce
fibrogenic
growth
factors,
crosstalk
between
macrophages
fibroblasts.
Transforming
factor
(TGF)-β
vascular
endothelial
(VEGF)-A
are
the
key
mediators
angiogenesis,
respectively.
Bioincompatible
upregulate
TGF-β
expression
mesothelial
cells
contributes
development
fibrosis.
Angiogenesis
lymphangiogenesis
can
progress
during
via
TGF-β–VEGF-A/C
pathways.
Complement
activation
occurs
fungal
peritonitis
progresses
insidiously
PD.
Analyses
human
have
clarified
mechanisms
which
encapsulating
sclerosis
develops.
Different
effects
dialysates
on
were
also
recognized,
particularly
terms
damage.
Understanding
pathophysiologies
will
lead
preservation
function
improvements
technical
survival,
mortality,
quality
life
for
patients.
Frontiers in Veterinary Science,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 25, 2024
Extracellular
vesicles
are
nanoscale
that
transport
signals
between
cells,
mediating
both
physiological
and
pathological
processes.
EVs
facilitate
conserved
intercellular
communication.
By
transferring
bioactive
molecules
coordinate
systemic
responses,
regulating
homeostasis,
immunity,
disease
progression.
Given
their
biological
importance
involvement
in
pathogenesis,
show
promise
as
biomarkers
for
veterinary
diagnosis,
candidates
vaccine
production,
treatment
agents.
Additionally,
different
or
engineering
methods
could
be
used
to
boost
the
capability
of
extracellular
vesicles.
Despite
emerging
interest,
EV
research
has
been
predominantly
human-based.
Critical
knowledge
gaps
remain
regarding
isolation
protocols,
cargo
loading
mechanisms,
vivo
biodistribution,
species-specific
functions.
Standardized
characterization
validation
lacking.
Regulatory
uncertainties
impede
clinical
translation.
Advances
fundamental
biology
technology
needed
propel
field
forward.
This
review
introduces
from
a
perspective
by
introducing
latest
studies,
highlighting
potential
while
analyzing
challenges
motivate
expanded
investigation
