Challenges and advances for glioma therapy based on inorganic nanoparticles DOI Creative Commons

Die Hu,

Miao Xia,

Linxuan Wu

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100673 - 100673

Published: June 1, 2023

Glioma is one of the most serious central nervous system diseases, with high mortality and poor prognosis. Despite continuous development existing treatment methods, median survival time glioma patients still only 15 months. The main difficulties are invasive growth obstruction blood-brain barrier (BBB) to drugs. With rapid advancements in nanotechnology, inorganic nanoparticles (INPs) have shown favourable application prospects diagnosis glioma. Due their extraordinary intrinsic features, INPs can be easily fabricated, while doping other elements surface modification by biological ligands used enhance BBB penetration, targeted delivery biocompatibility. Guided theranostics improve efficacy traditional methods such as chemotherapy, radiotherapy gene therapy. New strategies, immunotherapy, photothermal photodynamic therapy, magnetic hyperthermia multifunctional nanoplatforms, also been facilitated INPs. This review emphasizes current state research clinical applications INPs, including targeting penetration enhancement vivo vitro biocompatibility, diagnostic strategies. As such, it provides insights for novel

Language: Английский

Hydrogel systems for targeted cancer therapy DOI Creative Commons
Xinlin Li, Xinyi Xu,

Mengfei Xu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 16, 2023

When hydrogel materials with excellent biocompatibility and biodegradability are used as new drug carriers in the treatment of cancer, they confer following three advantages. First, can be a precise controlled release systems, which continuously sequentially chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents other substances widely cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy photothermal therapy. Second, have multiple sizes delivery routes, targeted to different locations types cancer. This greatly improves targeting thereby reducing dose drugs improving effectiveness. Finally, intelligently respond environmental changes according internal external stimuli so that anti-cancer active remotely released on demand. Combining abovementioned advantages, transformed into hit field treatment, bringing hope further increase survival rate quality life patients

Language: Английский

Citations

51
Metabolic Intervention Liposome Boosted Lung Cancer Radio‐Immunotherapy via Hypoxia Amelioration and PD‐L1 Restraint DOI Creative Commons

Saijun Wang,

Zaigang Zhou, Rui Hu

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(18)

Published: April 24, 2023

At present, radiotherapy (RT) still acquires limited success in clinical due to the lessened DNA damage under hypoxia and acquired immune tolerance owing amplified programmed death ligand-1 (PD-L1) expression. Incredibly, intracellular PD-L1 expression depression is proven better sensitize RT by inhibiting repair. However, disability of clinically used antibodies disrupting extracellular PD-L1function limits effectiveness radio-immunotherapy. Therefore, regulation strategies are urgently needed Hence, for this purpose, TPP-LND synthesized linking mitochondrial-targeted triphenylphosphine cations (TPP+ ) antineoplastic agent lonidamine (LND), which significantly reduces dose LND induce effective oxidative phosphorylation inhibition (2 vs 300 µM). Then, wrapped with liposomes form TPP-LND@Lip nanoparticles. By doing this, nanoparticles can reversing hypoxic microenvironment tumors generate more reducing via enhancing adenosine 5'-monophosphate-activated protein kinase activation. As expected, these well-designed economical than conventional anti-PD-L1 some extent.

Language: Английский

Citations

49
Biomaterials Facilitating Dendritic Cell‐Mediated Cancer Immunotherapy DOI Creative Commons
Heng Dong, Qiang Li, Yu Zhang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(18)

Published: April 23, 2023

Dendritic cell (DC)-based cancer immunotherapy has exhibited remarkable clinical prospects because DCs play a central role in initiating and regulating adaptive immune responses. However, the application of traditional DC-mediated is limited due to insufficient antigen delivery, inadequate presentation, high levels immunosuppression. To address these challenges, engineered biomaterials have been exploited enhance immunotherapeutic effects. In this review, vital principal components that can effects are first introduced. The parameters considered rational design biomaterials, including targeting modifications, size, shape, surface, mechanical properties, which affect biomaterial optimization DC functions, further summarized. Moreover, recent applications various field reviewed, those serve as component delivery platforms, remodel tumor microenvironment, synergistically other antitumor therapies. Overall, present review comprehensively systematically summarizes related promotion functions; specifically focuses on advances designs for activation eradicate tumors. challenges opportunities treatment strategies designed amplify via discussed with aim inspiring translation future immunotherapies.

Language: Английский

Citations

48
A Hybrid Nanoadjuvant Simultaneously Depresses PD‐L1/TGF‐β1 and Activates cGAS‐STING Pathway to Overcome Radio‐Immunotherapy Resistance DOI
Yi Lei, Xin Jiang, Zaigang Zhou

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Jan. 17, 2024

Abstract Currently, certain cancer patients exhibit resistance to radiotherapy due reduced DNA damage under hypoxic conditions and acquired immune tolerance triggered by transforming growth factor‐β1 (TGF‐β1) membrane‐localized programmed death ligand‐1 (PD‐L1). Meanwhile, cytoplasm‐distributed PD‐L1 induces through accelerating repair (DDR). However, the disability of clinically used antibodies in inhibiting limits their effectiveness. Therefore, a nanoadjuvant is developed sensitize via multi‐level immunity activation depressing TGF‐β1 triphenylphosphine‐derived metformin, activating cGAS‐STING pathway generating Mn 2+ from MnO 2 producing more dsDNA reversing tumor hypoxia impairing DDR. Thus, Tpp‐Met@MnO @Alb effectively enhances efficiency inhibit progression irradiated local abscopal tumors lung metastases, offering long‐term memory antitumor without discernible side effects. Overall, has potential be applied for overcoming radio‐immunotherapy resistance.

Language: Английский

Citations

30
Enhancing photodynamic immunotherapy by reprograming the immunosuppressive tumor microenvironment with hypoxia relief DOI

Mengying He,

Mengyao Zhang,

Tao Xu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 233 - 250

Published: Feb. 29, 2024

Language: Английский

Citations

20
Mitochondria Energy Metabolism Depression as Novel Adjuvant to Sensitize Radiotherapy and Inhibit Radiation Induced‐Pulmonary Fibrosis DOI Creative Commons
Zaigang Zhou, Xin Jiang, Yi Lei

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 7, 2024

Abstract Currently, the typical combination therapy of programmed death ligand‐1 (PD‐L1) antibodies with radiotherapy (RT) still exhibits impaired immunogenic antitumor response in clinical due to lessened DNA damage and acquired immune tolerance via upregulation some other checkpoint inhibitors. Apart from this, such may raise occurrence rate radiation‐induced lung fibrosis (RIPF) enhanced systemic inflammation, leading ultimate cancer patients (average survival time about 3 years). Therefore, it is newly revealed that mitochondria energy metabolism regulation can be used as a novel effective PD‐L1 transforming growth factor‐β (TGF‐β) dual‐downregulation method. Following IR‐TAM prepared by conjugating mitochondria‐targeted heptamethine cyanine dye IR‐68 oxidative phosphorylation (OXPHOS) inhibitor Tamoxifen (TAM), which then self‐assembled albumin (Alb) form IR‐TAM@Alb nanoparticles. By doing tumor‐targeting nanoparticle effectively reversed tumor hypoxia depressed TGF‐β expression sensitize RT. Meanwhile, capacity targeting RIPF function TAM depressing TGF‐β, also ameliorated development induced

Language: Английский

Citations

20
Dual‐Responsive Supramolecular Polymeric Nanomedicine for Self‐Cascade Amplified Cancer Immunotherapy DOI Creative Commons

Wenting Hu,

Binglin Ye,

Guocan Yu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(20)

Published: March 17, 2024

Abstract Insufficient tumor immunogenicity and immune escape from tumors remain common problems in all immunotherapies. Recent studies have shown that pyroptosis, a form of programmed cell death is accompanied by checkpoint inhibitors, can induce effective immunogenic long‐term activation. Therapeutic strategies to jointly pyroptosis reverse immunosuppressive microenvironments are promising for cancer immunotherapy. In this regard, dual‐responsive supramolecular polymeric nanomedicine (NCSNPs) self‐cascade amplify the benefits immunotherapy designed. The NCSNPs formulated β‐cyclodextrin coupling nitric oxide (NO) donor, activator, NLG919, an indoleamine 2,3‐dioxygenase (IDO) inhibitor, self‐assembled through host–guest molecular recognition hydrophobic interaction obtain nanoparticles. possess excellent accumulation bioavailability attributed ingenious engineering. study not only confirms occurrence NO‐triggered first time but also reverses microenvironment sites via IDO inhibitor enhancing infiltration cytotoxic T lymphocytes, achieve remarkable inhibition proliferation. Thus, provides novel strategy

Language: Английский

Citations

18
Mitochondria‐Targeted Nanoadjuvants Induced Multi‐Functional Immune‐Microenvironment Remodeling to Sensitize Tumor Radio‐Immunotherapy DOI Creative Commons
Zaigang Zhou, Cheng Li, Chao Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 5, 2024

Abstract It is newly revealed that collagen works as a physical barrier to tumor immune infiltration, oxygen perfusion, and depressor in solid tumors. Meanwhile, after radiotherapy (RT), the programmed death ligand‐1 (PD‐L1) overexpression transforming growth factor‐β (TGF‐β) excessive secretion would accelerate DNA damage repair trigger T cell exclusion limit RT efficacy. However, existing drugs or nanoparticles can hardly address these obstacles of highly effective simultaneously, effectively, easily. In this study, it inducing mitochondria dysfunction by using oxidative phosphorylation inhibitors like Lonidamine (LND) serve multi‐immune pathway regulation strategy through PD‐L1, collagen, TGF‐β co‐depression. Then, IR‐LND prepared combining mitochondria‐targeted molecule IR‐68 with LND, which then loaded liposomes (Lip) create IR‐LND@Lip nanoadjuvants. By doing this, more effectively sensitizes generating cold tumors into hot ones activation co‐inhibition. conclusion, combined treatment ultimately almost completely suppressed bladder breast

Language: Английский

Citations

17
Recent strategies for evoking immunogenic Pyroptosis in antitumor immunotherapy DOI Creative Commons

Zhangxin He,

Dexiang Feng,

Chaoji Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 375 - 394

Published: Jan. 9, 2024

Pyroptosis is a specific type of programmed cell death (PCD) characterized by distinct morphological changes, including swelling, membrane blebbing, DNA fragmentation, and eventual lysis. closely associated with human-related diseases, such as inflammation malignancies. Since the initial observation pyroptosis in Shigella flexneri-infected macrophages more than 20 years ago, various pyroptosis-inducing agents, ions, small molecules, biological nanomaterials, have been developed for tumor treatment. Given that can activate body's robust immune response against promote formation long-term memory treatment, its status immunogenic self-evident. Therefore, should be used powerful anti-tumor strategy. However, there still lack comprehensive summary most recent advances pyroptosis-based cancer therapy. it vital to fill this gap inspire future drug design better induce cells undergo achieve advanced effects. In review, we summarize detail triggering adequate clearance based on treatment modalities, highlight material therapeutic advantages. Besides, also provide an outlook prospects emerging field next development.

Language: Английский

Citations

16
Reprogramming exosomes for immunity-remodeled photodynamic therapy against non-small cell lung cancer DOI Creative Commons

Jiao Guo,

Wei Zhao, Xinyu Xiao

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 206 - 223

Published: May 21, 2024

Traditional treatments against advanced non-small cell lung cancer (NSCLC) with high morbidity and mortality continue to be dissatisfactory. Given this situation, there is an urgent requirement for alternative modalities that provide lower invasiveness, superior clinical effectiveness, minimal adverse effects. The combination of photodynamic therapy (PDT) immunotherapy gradually become a promising approach high-grade malignant NSCLC. Nevertheless, owing the absence precise drug delivery techniques as well hypoxic immunosuppressive characteristics tumor microenvironment (TME), efficacy less than ideal. In study, we construct novel nanoplatform indocyanine green (ICG), photosensitizer, loads into hollow manganese dioxide (MnO

Language: Английский

Citations

16