Macromolecular Materials and Engineering,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
Abstract
Lung
cancer
remains
one
of
the
deadliest
cancers,
marked
by
uncontrolled
cell
growth
in
lungs
and
often
diagnosed
at
later
stages.
This
study
presents
a
novel
hydrogel‐embedded
nanocomposite
responsive
to
Near‐Infrared
(NIR)
light
(CN‐Pt‐DOX@CS+NIR)
induce
necroptosis
lung
cells.
The
composite,
created
combining
Carbon
Nanodots
(CNs),
Platinum
Nanoparticles
(PtNPs),
Doxorubicin
(DOX)
within
Chitosan
(CS)‐based
hydrogel,
demonstrated
favorable
properties
for
sustained
drug
release.
Upon
NIR
irradiation,
CNs
increase
oxidative
stress
initiate
apoptosis
due
generation
reactive
oxygen
species
(ROS)
caspase
activation
(3,
8,
9).
PtNPs
enhance
ROS
production
disrupt
mitochondrial
membrane
potential
(MMP),
further
promoting
death.
DOX,
well‐known
chemotherapeutic,
intercalates
DNA
inhibits
topoisomerase
II,
leading
apoptosis.
These
combined
effects
result
significant
cytotoxicity
under
stimulation,
as
shown
vitro
on
A549
H1299
cells,
confirmed
through
various
assays
including
AO/EB
DAPI
staining,
flow
cytometry,
RT‐PCR.
Additionally,
hydrogel
matrix
provides
controlled
release
therapeutic
agents
improves
localized
delivery.
Combining
CNs,
PtNPs,
DOX
with
enhanced
cytotoxic
effects,
apoptosis,
generation,
targeted
therapy.
Coordination Chemistry Reviews,
Journal Year:
2024,
Volume and Issue:
508, P. 215754 - 215754
Published: March 12, 2024
The
science
of
nanotechnology
has
been
proposed
as
a
factor
main
change
in
the
field
cancer
diagnosis
and
treatment.
challenges
common
clinical
treatment
breast
can
be
dominate
by
proof
targeting
cells
nanoscale
drug
delivery
system.
Due
to
specific
properties
nanoparticles
such
biocompatibility,
minimum
toxicity,
excellent
stability,
multifunctional
encapsulations
therapeutic
agents,
increased
permeability
retention
effect,
selective
targeting,
they
apply
for
therapy.
Multidrug
resistance
many
chemotherapy
drugs
is
one
conventional
that
overcome
nanoparticles.
However,
vivo
vitro
studies
limited
this
field,
number
approved
nano
formulation
not
significantly
over
years.
Successful
translation
nanomedicines
arduous
requiring
considerable
preclinical
tests.
Two-dimensional
(2D)
monolayer
cell
cultures
animal
models,
which
are
routinely
used
research
discovery/screening
seem
inadequate.
To
address
challenge,
biomimetic
three-dimensional
(3D)
tumor
models
like
spheroids,
organoids,
scaffolds/hydrogels,
bioprinted,
microfluidic
chips
have
established
using
engineering
approach.
Taking
physiopathology
microenvironment
into
account,
potential
enhance
disease
modeling
drug/nanomedicine
screening.
development
3D
comprised
patient's
own
cancer,
stromal,
immune
exploited
promising
platform
provide
personalized
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 23, 2024
Conventional
therapeutic
models
based
on
the
premise
of
a
universal
solution
are
facing
decrease
in
efficiency,
emphasized
by
large
number
patients
who
show
resistance
or
do
not
respond
positively
to
classic
treatments.
This
perspective
highlights
urgency
for
more
precise
approaches
personalized
treatments
that
adaptable
specific
complexities
and
unique
challenges
faced
each
patient.
Hydrogels
biocompatible
biodegradable
systems
well-controlled
targeted
administration
agents,
being
formed
3D
reticulated
networks
water-soluble
polymeric
biomaterials,
natural,
synthetic,
hybrid
origin,
with
intrinsic
extrinsic
properties.
Due
easily
adjustable
porous
structure,
hydrogels
allow
encapsulation
macromolecular
drugs,
proteins,
small
molecules,
cells,
hormones,
growth
factors
gel
matrix
their
subsequent
controlled
release.
The
biomaterials
used,
crosslinking
methods,
design,
functionalization
strategies
obtaining
improved
properties
presented.
different
possibilities
application
described
transdermally,
as
dressing
materials,
oral,
ocular,
spray-able,
injectable,
up
intracellular
level.
chapter
extensively
investigates
advances
advantages
enable
effective,
noninvasive,
provide
greater
patient
comfort
wide
range
applications.
Gels,
Journal Year:
2024,
Volume and Issue:
10(6), P. 381 - 381
Published: June 2, 2024
At
the
forefront
of
advanced
material
technology,
radiation-induced
hydrogels
present
a
promising
avenue
for
innovation
across
various
sectors,
utilizing
gamma
radiation,
electron
beam
and
UV
radiation.
Through
unique
synthesis
process
involving
radiation
exposure,
these
exhibit
exceptional
properties
that
make
them
highly
versatile
valuable
multitude
applications.
This
paper
focuses
on
intricacies
methods
employed
in
creating
hydrogels,
shedding
light
their
structural
characteristics
functional
benefits.
In
particular,
analyzes
diverse
utility
biomedicine
agriculture,
showcasing
potential
applications
such
as
targeted
drug
delivery,
injury
recovery,
even
environmental
engineering
solutions.
By
analyzing
current
research
trends
highlighting
future
directions,
this
review
aims
to
underscore
transformative
impact
could
have
industries
advancement
biomedical
agricultural
practices.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(7), P. 4666 - 4691
Published: Jan. 1, 2024
Despite
the
advancements
in
cancer
therapies
during
past
few
years,
chemo/photo
resistance,
severe
toxic
effects,
recurrence
of
metastatic
tumors,
and
non-selective
targeting
remain
incomprehensible.
Discover Materials,
Journal Year:
2024,
Volume and Issue:
4(1)
Published: Aug. 28, 2024
Nanocomposite
hydrogels
(NHs)
have
emerged
as
a
groundbreaking
tool
in
biomedical
applications,
offering
remarkable
versatility
and
efficacy.
Integrating
wide
range
of
nanoparticles,
including
carbon-based,
polymeric,
ceramic,
metallic
nanomaterials,
within
hydrogel
networks
results
nanocomposites
with
superior
properties
tailored
functionalities.
Recent
research
has
highlighted
their
potential
to
address
key
challenges
drug
delivery,
cancer
therapy,
tissue
regeneration,
biosensing,
wound
healing,
outstanding
biocompatibility
bioavailability.
Nanohydrogels
demonstrate
significant
promise
delivery
systems
biological
sensors,
providing
sustained
therapeutic
activity
at
targeted
sites.
This
reduces
the
frequency
administration
minimizes
harmful
side
effects.
In
healthcare
sector,
they
applications
ranging
from
therapy
aesthetic
corrections
are
leading
topic
regeneration
research.
comprehensive
review
Biomedical
Applications
investigates
latest
advancements
NHs,
focusing
on
classification,
unique
properties,
diverse
applications.
By
identifying
future
prospects
existing
gaps,
this
aims
highlight
diagnostic
nanocomposite
technology,
covering
way
for
further
advancement
field.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(36), P. 42965 - 42980
Published: Sept. 1, 2023
Titanium-based
implants
often
lead
to
premature
implant
failure
due
the
lack
of
antimicrobial,
osteogenic,
and
angiogenic
properties.
To
this
end,
a
new
strategy
was
developed
fabricate
CaO2@ZIF-67-HA-ADH
coating
on
titanium
surfaces
by
combining
calcium
peroxide
(CaO2)
nanoparticles,
zeolite
imidazolate
framework-67
(ZIF-67),
chemical
coupling
hyaluronic
acid-adipic
acid
dihydrazide
(HA-ADH).
We
characterized
with
scanning
electron
microscopy
(SEM),
transmission
(TEM),
Fourier
transform
infrared
(FTIR)
spectroscopy,
X-ray
photoelectron
spectroscopy
(XPS),
inductively
coupled
plasma-atomic
emission
spectrometry
(ICP-AES).
The
results
demonstrated
that
pH-sensitive
decomposed
rapidly
under
acidic
conditions,
it
released
inclusions
slowly
neutral
conditions.
Antibacterial
experiments
showed
had
excellent
antibacterial
properties
effectively
killed
methicillin-resistant
Staphylococcus
aureus
(MRSA)
Pseudomonas
aeruginosa
(PAO-1).
Cell
revealed
promoted
pro-osteoblast
adhesion,
proliferation,
differentiation
also
migration
angiogenesis
human
umbilical
vein
endothelial
cells
(HUVECs),
exhibiting
osteogenic
In
in
vivo
animal
implantation
experiments,
exhibited
strong
antimicrobial
activity
early
after
osseointegration
later
implantation.
conclusion,
pH-responsive
conferred
antibacterial,
implants,
which
enhanced
prevented
bacterial
infection;
shows
promise
for
use
treatment
bone
defects.
Materials,
Journal Year:
2024,
Volume and Issue:
17(6), P. 1423 - 1423
Published: March 20, 2024
MXenes
are
two-dimensional
transition
metal
carbides,
nitrides,
and
carbonitrides
that
have
become
important
materials
in
nanotechnology
because
of
their
remarkable
mechanical,
electrical,
thermal
characteristics.
This
review
emphasizes
how
crucial
MXene
conjugates
for
several
biomedical
applications,
especially
the
field
cancer.
These
(2D)
nanoconjugates
with
photothermal,
chemotherapeutic,
photodynamic
activities
demonstrated
promise
highly
effective
noninvasive
anticancer
therapy.
conjugates,
distinctive
optical
capabilities,
been
employed
bioimaging
biosensing,
excellent
light-to-heat
conversion
efficiency
makes
them
perfect
biocompatible
notably
proficient
nanoscale
agents
photothermal
applications.
The
synthesis
characterization
provide
a
framework
an
in-depth
understanding
various
fabrication
techniques
importance
customized
formation
conjugates.
following
sections
explore
MXene-based
nanotheranostics
demonstrate
enormous
potential
Nanoconjugates,
such
as
polymers,
metals,
graphene,
hydrogels,
biomimetics,
quantum
dots,
radio
exhibit
unique
properties
can
be
used
therapeutic
diagnostic
applications
cancer
nanotheranostics.
An
additional
layer
into
safety
concerns
is
provided
by
detailing
toxicity
viewpoints.
Furthermore,
concludes
addressing
opportunities
challenges
clinical
translation
nanoconjugates,
emphasizing
real-world
medical
practices.
