A glutathione-activated bismuth-gallic acid metal-organic framework nano-prodrug for enhanced sonodynamic therapy of breast tumor

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 679, P. 214 - 223

Published: Sept. 29, 2024

Language: Английский

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Facile Synthesis of a Multifunctional Porous Organic Polymer Nanosonosensitizer (mHM@HMME) for Enhanced Cancer Sonodynamic Therapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(22), P. 28104 - 28117

Published: May 20, 2024

Sonodynamic therapy (SDT), which involves the activation of sonosensitizers to generate cytotoxic reactive oxygen species under ultrasound irradiation, is a promising noninvasive modality for cancer treatment. However, clinical translational application SDT impeded by lack efficient sonosensitizers, inefficient accumulation at tumor sites, and complicated immunosuppressive microenvironment. Herein, we developed facilely synthesized multifunctional porous organic polymer nanosonosensitizer (mHM@HMME) enhanced SDT. Specifically, mHM@HMME nanosonosensitizers were prepared incorporating chemotherapeutic mitoxantrone into one-step synthesis process disulfide bond containing polymers, followed loading with sonosensitizer (HMME) camouflaging cell membrane. Due membrane camouflage, this showed prolonged blood circulation targeting aggregation. Under exhibited satisfactory performance both in vitro vivo. Moreover, potent combined glutathione-responsive drug release cells induced robust immunogenic death enhance antitumor effect turn. Overall, shows great potential

Language: Английский

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Oxidative Stress-Induced Gastrointestinal Diseases: Biology and Nanomedicines—A Review

BioChem, Journal Year: 2024, Volume and Issue: 4(3), P. 189 - 216

Published: July 29, 2024

Gastrointestinal diseases have been among the main concerns of medical and scientific societies for a long time. Several studies emphasized critical role oxidative stress in pathogenesis most common gastrointestinal diseases. To provide comprehensive overview caused by stress, their biological aspects, molecular mechanisms specific pathways, results recent published articles from online databases were studied considering both upper lower parts digestive tract. The revealed that although each part system manifests itself way, all these arise imbalance between generation reactive intermediates (especially oxygen species) antioxidant defense system. Annual incidence mortality statistics worldwide emphasize urgent need to find an effective non-invasive treatment method overcome life-threatening problems. Therefore, next step, variety nanomedicurfines developed treat effect investigated precisely. Furthermore, important nanomedicines responsive endogenous exogenous stimuli evaluated detail. This review could pave way open new horizon effectively treating

Language: Английский

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Design strategies and applications of cyanine dyes in phototherapy

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

An overview of cyanine dye-based phototherapy agents, including the design strategies, relationships between molecular structures and properties, as well applications in photodynamic therapy, photothermal multimodal combined therapy.

Language: Английский

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Sonocatalytic cancer therapy: theories, advanced catalysts and system design

Nanoscale, Journal Year: 2023, Volume and Issue: 15(48), P. 19407 - 19422

Published: Jan. 1, 2023

Sonocatalytic cancer therapy has emerged as a promising strategy through the combination of ultrasound waves and catalytic materials to selectively target destroy cells.

Language: Английский

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