Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(22), P. 5656 - 5679
Published: Jan. 1, 2024
This review is focused on using natural products for cancer therapy by inducing pyroptosis-related signaling pathways. Natural product-based compounds can also be combined with other antitumor therapies a synergistic effect.
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(45)
Published: Sept. 17, 2024
Abstract The overexpression of polyamines in tumor cells contributes to the establishment immunosuppressive microenvironment and facilitates growth. Here, it have ingeniously designed multifunctional copper‐piceatannol/HA nanopills (Cu‐Pic/HA NPs) that effectively cause total intracellular depletion by inhibiting synthesis, depleting polyamines, impairing uptake, resulting enhanced pyroptosis cuproptosis, thus activating a powerful immune response achieve anti‐tumor therapy. Mitochondrial dysfunction from overall not only leads surge copper ions mitochondria, thereby causing aggregation toxic proteins induce but also triggers accumulation reactive oxygen species (ROS) within which further upregulates expression zDHHC5 zDHHC9 promote palmitoylation gasdermin D (GSDMD) GSDMD‐N, ultimately inducing pyroptosis. Then occurrence cuproptosis is conductive remodel microenvironment, responses growth metastasis. This therapeutic strategy through comprehensive provides novel template for cancer immunotherapy.
Language: Английский
Citations
17
Small, Journal Year: 2024, Volume and Issue: 20(44)
Published: July 6, 2024
Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.
Language: Английский
Citations
12
Theranostics, Journal Year: 2025, Volume and Issue: 15(8), P. 3490 - 3516
Published: Feb. 24, 2025
Rationale: Dental implant restoration is essential for rehabilitating dentition defects. However, peri-implantitis (PI) seriously threatens the long-term stability of implants. Treating PI requires complete eradication plaque biofilm and meticulous modulation inflammatory responses. Antibacterial photodynamic therapy (aPDT) presents a promising potential in antibacterial realm. Nonetheless, traditional aPDT faces challenges such as inadequate penetration distribution photosensitizers, well lack precise bacteria targeting. Moreover, excessive ROS generated by will aggravate oxidative stress peri-implant tissues, this issue cannot be neglected. Methods: The CuTA-Por@ε-PL nanoplatforms (CPP NPs) were synthesized characterized using dynamic light scattering, transmission electron microscopy, dye probes detail. anti-inflammatory activities CPP NPs evaluated both vitro vivo. vivo therapeutic efficacy was successively analyzed through micro-CT, hematoxylin eosin staining, Masson's immunofluorescence colony formation units (CFU), among other techniques. Results: Porphyrin (Por), CuTA nanozyme with SOD/CAT activities, ε-Polylysine (ε-PL) combined to fabricate via straightforward approach. notable positive charge facilitated penetration, Then, irradiation 660 nm laser triggered burst elimination. After aPDT, scavenged residual modulated host immunity regulating macrophage polarization. As result, CPP-treated groups demonstrated most outstanding performance rat model. Conclusions: Given pathogenesis PI, strategy rationally designed multifunctional NP functions spatiotemporal regulation. It provides potentially novel approach treatment, which may have profound impact on improving prognosis patients advancing field dentistry.
Language: Английский
Citations
1
Advanced Science, Journal Year: 2024, Volume and Issue: 11(44)
Published: Oct. 9, 2024
Abstract Immunotherapy represents a widely employed modality in clinical oncology, leveraging the activation of human immune system to target and eradicate cancer cells tumor tissues via endogenous mechanisms. However, its efficacy remains constrained by inadequate responses within “cold” microenvironment (TME). In this study, multifunctional nanoscale pyroptosis inducer with cascade enzymatic activity (IMZF), comprising superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione oxidase (GSHO x ), is dissociated acidic glutathione‐rich TME. The vigorous not only generates oxygen (O 2 ) alleviate hypoxia promote M2 M1 macrophage polarization but also yields reactive species (ROS) depletes (GSH) Functioning as an immunogenic cell death (ICD) activator inducer, IMZF synergistically triggers dendritic maturation inflammatory lymphocyte infiltration ICD‐associated pyroptosis, thereby reversing suppression TMEs. Consequently, it exerts inhibitory effects on both primary distal tumors. This platform‐based offers intelligent strategy for effectively overcoming tumors, providing promising avenue advanced immunotherapeutic interventions.
Language: Английский
Citations
7
Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122805 - 122805
Published: Sept. 3, 2024
Language: Английский
Citations
5
Nano Today, Journal Year: 2025, Volume and Issue: 61, P. 102640 - 102640
Published: Jan. 14, 2025
Language: Английский
Citations
0
Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123571 - 123571
Published: Feb. 1, 2025
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123207 - 123207
Published: Feb. 28, 2025
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Photodynamic therapy (PDT) has emerged as a promising modality for cancer treatment, but its clinical application is constrained by unexpected phototoxicity arising from nonspecific photosensitizer activation and their "always-on" nature. Herein, we developed switchable nanophotosensitizer, poly(cation-π) nanoparticles (NP), which achieves supramolecular assembly through cation-π interactions. By coupling choline cationic moieties with aromatic photosensitizers (ZnPc), the polymer facilitates self-assembly driven interactions NP engineering. Surprisingly, photoactivity of ZnPc was completely quenched upon complexation via interactions, thereby significantly avoiding skin phototoxicity. Upon targeting tumor cells, undergoes GSH-responsive degradation process that weakens leading to spontaneous restoration amplifying immunogenic pyroptosis. In vivo studies demonstrated achieved high inhibition rate 84% while effectively This work provides novel perspective enhancing safety efficacy PDT-based treatment.
Language: Английский
Citations
0
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(22), P. 5656 - 5679
Published: Jan. 1, 2024
This review is focused on using natural products for cancer therapy by inducing pyroptosis-related signaling pathways. Natural product-based compounds can also be combined with other antitumor therapies a synergistic effect.
Language: Английский
Citations
1