Journal of Biomaterials Applications,
Journal Year:
2024,
Volume and Issue:
39(5), P. 439 - 454
Published: Aug. 28, 2024
Since
conventional
antibiotics
are
almost
ineffective
on
methicillin-resistant
Staphylococcus
aureus
(MRSA)
strains,
designing
their
antibacterial
alternatives
is
necessary.
Besides,
the
use
of
vancomycin
applied
for
specific
detection
bacteria.
Silver-incorporated
vancomycin-modified
mesoporous
silica
nanoparticles
(MSNs@Van@Ag
NPs)
were
designed
and
treatment
MRSA
Mesoporous
(MSNs)
synthesized
through
template
method,
modified
with
vancomycin,
finally
incorporated
silver
(Ag
NPs).
The
MSNs@Van@Ag
NPs
a
homogenously
spherical
shape,
average
size
50-100
nm,
surface
area
955.8
m
2
/g,
thermal
stability
up
to
200°C
successfully
characterized.
amount
Ag
into
was
calculated
at
3.9
ppm
release
received
2.92
(75%)
after
100
h.
in
vitro
susceptibility
test
showed
MIC
μg
mL
−1
MSNs@Van
50
MSNs@Van@Ag,
showing
enhanced
effect
bactericidal
process.
An
vivo
acute
pneumonia
model
performed
biochemical
assays
pathological
studies
confirmed
nanomedicine’s
short-term
safety
application.
Cytokine
assay
using
ELISA
that
MSN@Van@Ag
causes
reduction
pro-inflammatory
cytokines
bacterial
proliferation
leading
alleviation
inflammatory
response.
Advances in Colloid and Interface Science,
Journal Year:
2023,
Volume and Issue:
322, P. 103035 - 103035
Published: Nov. 3, 2023
Surface-functionalized
nanostructures
are
at
the
forefront
of
biotechnology,
providing
new
opportunities
for
biosensors,
drug
delivery,
therapy,
and
bioimaging
applications.
The
modification
significantly
impacts
performance
success
various
applications
by
enabling
selective
precise
targeting.
This
review
elucidates
widely
practiced
surface
strategies,
including
click
chemistry,
cross-coupling,
silanization,
aldehyde
linkers,
active
ester
maleimide
epoxy
other
protein
DNA-based
methodologies.
We
also
delve
into
application-focused
landscape
nano-bio
interface,
emphasizing
four
key
domains:
therapeutics,
biosensing,
environmental
monitoring,
point-of-care
technologies,
highlighting
prominent
studies.
insights
presented
herein
pave
way
further
innovations
intersection
nanotechnology
a
useful
handbook
beginners
professionals.
draws
on
sources,
latest
research
articles
(2018-2023),
to
provide
comprehensive
overview
field.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(3), P. 303 - 303
Published: Feb. 1, 2024
Recently,
drug
delivery
strategies
based
on
nanomaterials
have
attracted
a
lot
of
interest
in
different
kinds
therapies
because
their
superior
properties.
Polydopamine
(PDA),
one
the
most
interesting
materials
nanomedicine
its
versatility
and
biocompatibility,
has
been
widely
investigated
field.
It
can
be
easily
functionalized
to
favor
processes
like
cellular
uptake
blood
circulation,
it
also
induce
release
through
two
stimuli:
NIR
light
irradiation
pH.
In
this
review,
we
describe
PDA
nanomaterials’
performance
delivery,
size,
morphology,
surface
charge.
Indeed,
these
characteristics
strongly
influence
main
mechanisms
involved
system:
uptake,
loading,
release.
The
understanding
connections
between
nanosystems’
properties
phenomena
is
pivotal
obtain
controlled
design
new
nanocarriers
specific
applications.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Nov. 29, 2023
Abstract
Traditional
Chinese
Medicines
(TCMs)
have
been
used
for
centuries
the
treatment
and
management
of
various
diseases.
However,
their
effective
delivery
to
targeted
sites
may
be
a
major
challenge
due
poor
water
solubility,
low
bioavailability,
potential
toxicity.
Nanocarriers,
such
as
liposomes,
polymeric
nanoparticles,
inorganic
nanoparticles
organic/inorganic
nanohybrids
based
on
active
constituents
from
TCMs
extensively
studied
promising
strategy
improve
achieve
higher
therapeutic
effect
with
fewer
side
effects
compared
conventional
formulations.
This
review
summarizes
recent
advances
in
nanocarrier-based
systems
types
TCMs,
including
terpenoids,
polyphenols,
alkaloids,
flavonoids,
quinones,
different
natural
sources.
covers
design
preparation
nanocarriers,
characterization,
vitro/vivo
evaluations.
Additionally,
this
highlights
challenges
opportunities
field
suggests
future
directions
research.
Nanocarrier-based
shown
great
improving
efficacy
serve
comprehensive
resource
researchers
field.
Graphical
abstract
International Journal of Pharmaceutics X,
Journal Year:
2024,
Volume and Issue:
8, P. 100281 - 100281
Published: Aug. 28, 2024
Cancer
is
the
leading
cause
of
death
globally,
and
conventional
treatments
have
limited
efficacy
with
severe
side
effects.
The
use
nanotechnology
has
potential
to
reduce
effects
drugs
by
creating
efficient
controlled
anticancer
drug
delivery
systems.
Nanoparticles
(NPs)
used
as
carriers
offer
several
advantages,
including
enhanced
protection,
biodistribution,
selectivity
and,
pharmacokinetics.
Therefore,
this
review
devoted
various
organic
(lipid,
polymeric)
well
inorganic
nanoparticles
based
on
different
building
units
providing
a
wide
range
potent
Within
these
nanoparticulate
systems,
chitosan
(CS)-based
NPs
are
discussed
particular
emphasis
due
unique
properties
CS
its
derivatives
non-toxicity,
biodegradability,
mucoadhesivity,
tunable
physico-chemical
biological
allowing
their
alteration
specifically
target
cancer
cells.
In
context
streamlining
systems
(DDS),
innovative
nanoplatform-based
therapy
pathways
involving
passive
active
targeting
stimuli-responsive
DDS
enhancing
overall
orthogonality
developed
NP-DDS
towards
included.
most
up-to-date
information
delivering
anti-cancer
using
modern
dosage
forms
specifically,
CSNPs,
summarised
evaluated
concerning
benefits,
limitations,
advanced
applications.
