Niosomal Bupropion: Exploring Therapeutic Frontiers through Behavioral Profiling

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(3), P. 366 - 366

Published: March 12, 2024

Bupropion (Bup) belongs to the norepinephrine–dopamine reuptake inhibitor (NDRI) class and it is only FDA-approved drug of its for treatment major depressive disorder (MDD), sold under name Wellbutrin. Although bupropion effective in suppressing symptoms, regular use overdose might lead seizures liver failure. Thus, we aimed nanoformulate onto a niosomal vesicle improve efficacy achieve same therapeutic effect at lower scheduled doses. A thin film hydration method was adopted synthesize optimize Bup entrapped niosomes using three different surfactants sorbitan ester series (Span 20, 40, 60) combination with cholesterol. The optimization data determined that niosome formulated cholesterol-to-surfactant ratio 1:1.5 most stable system, containing Span 20 (Bup@N20C) exhibiting minimal vitro vivo toxicity, demonstrating sustained release artificial cerebrospinal fluid (ACSF). Bup@N20C formulation showed increased exploration activity reduced irregular movements reserpine-induced depression adult zebrafish model, suggesting potential mood improvement through suppression depression-like behavior which established by statistical analysis trajectory data. Bup@N20C-treated group even surpasses positive control comparable group. Hence, can be inferred formulations represent promising delivery system capable achieving brain cargo bypassing blood–brain barrier facilitated their small architectural structure.

Language: Английский

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Facile sonochemically-assisted bioengineering of titanium dioxide nanoparticles and deciphering their potential in treating breast and lung cancers: biological, molecular, and computational-based investigations

RSC Advances, Journal Year: 2024, Volume and Issue: 14(12), P. 8583 - 8601

Published: Jan. 1, 2024

Combining sonochemistry with phytochemistry is a modern trend in the biosynthesis of metallic nanoparticles (NPs), which contributes to sustainability chemical processes and minimizes hazardous effects.

Language: Английский

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Advancements in Protein-Based Bionanocomposites for Targeted and Controlled Drug Delivery Systems: A Comprehensive Review

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106698 - 106698

Published: Feb. 1, 2025

Language: Английский

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Formulation, pharmacokinetics, and antibacterial activity of florfenicol-loaded niosome

Drug Delivery and Translational Research, Journal Year: 2023, Volume and Issue: 14(4), P. 1077 - 1092

Published: Nov. 13, 2023

Abstract The growing interest in employing nano-sized pharmaceutical formulations veterinary medicine has prompted the exploration of novel nanocarriers’ ability to augment therapeutic outcome. In this study, we harnessed niosomes, spherical nanocarriers formed through non-ionic surfactant self-assembly, enhance efficacy broad-spectrum antibiotic florfenicol. Pre-formulation studies were conducted identify optimal parameters for preparing florfenicol-loaded niosomes (FLNs). These revealed that formulation consisted Span 60, cholesterol, and dihexadecyl phosphate (DDP) at a molar ratio 1:1:0.1 exhibited highest entrapment efficiency (%EE) uniform size distribution. vitro antibacterial testing demonstrated niosomal capacity significantly reduce florfenicol minimum inhibitory concentration (MIC) against E. coli S. aureus . Pharmacokinetic profiles free FLN assessed following oral administration 30 mg florfenicol/kg body weight healthy or –infected chickens. substantially higher maximum plasma ( C max ) compared Furthermore, showed area under curve (AUC 0–t than as from relative bioavailability studies. Lethal dose (LD) 50 values both exceeded 5 g/kg weight, indicating high safety profile. Assessment mortality protection mice lethal infections capability improve survival rate (75%) (25%). Collectively, these findings demonstrate well activity incorporated Graphical abstract

Language: Английский

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Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer

Nanoscale, Journal Year: 2023, Volume and Issue: 16(6), P. 2713 - 2746

Published: Dec. 7, 2023

Nanoniosome-based drug codelivery systems have become popular therapeutic instruments, demonstrating tremendous promise in cancer therapy, infection treatment, and other domains. An emerging form of vesicular nanocarriers, niosomes are self-assembling vesicles composed nonionic surfactants, along with cholesterol or amphiphilic molecules. This comprehensive review focuses on how nanosystems may aid making anticancer antibacterial pharmaceuticals more stable soluble. As malleable nanodelivery the composition, types, preparation procedures, variables affecting structure stability extensively investigated. In addition, advantages dual for combination therapy administration multiple medications simultaneously highlighted. Along categorizing niosomal delivery systems, a analysis various techniques, including thin-layer injection, ether microfluidization, is provided. Dual treatment discussed detail regarding two organic, plant-based bioactive compounds gene agents. niogelosomes metallic carriers targeted distribution discussed. The also investigates simultaneous substances agents, siRNA, microRNA, shRNA, lncRNA, DNA. Additional sections discuss use cutaneous treating leishmanial infections,

Language: Английский

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Optimized mucoadhesive niosomal carriers for intranasal delivery of carvedilol: A quality by design approach

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 654, P. 123935 - 123935

Published: Feb. 21, 2024

Language: Английский

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From antigen uptake to immune modulation: the multifaceted potential of peptide nanofibers as vaccine nanocarriers

Materials Advances, Journal Year: 2024, Volume and Issue: 5(10), P. 4112 - 4130

Published: Jan. 1, 2024

Peptide nanofibers have exhibited a remarkable ability to enhance immune response induction. Herein, we explore the peptide nanofibers' transformative potential, providing comprehensive examination of their application in vaccine development.

Language: Английский

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Synergistic Enhancement of Carboplatin Efficacy through pH-Sensitive Nanoparticles Formulated Using Naturally Derived Boswellia Extract for Colorectal Cancer Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1282 - 1282

Published: Sept. 30, 2024

Carboplatin (Cp) is a potent chemotherapeutic agent, but its effectiveness constrained by associated side effects. Frankincense, an oleo-gum resin from the

Language: Английский

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Liposomes and Niosomes: New trends and applications in the delivery of bioactive agents for cancer therapy

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124994 - 124994

Published: Nov. 1, 2024

Language: Английский

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Enhanced Efficacy and Bioavailability of Amikacin-Loaded Niosomal Nanovesicles Based on Low-HLB Amphiphiles: In Vitro/Ex Vivo/In Vivo Studies

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106709 - 106709

Published: Feb. 1, 2025

Language: Английский

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