STIMULI-RESPONSIVE SUPRAMOLECULAR HYDROGELS FOR PACLITAXEL DELIVERY: PROGRESS AND PROSPECTS

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: 5, P. 100062 - 100062

Published: Jan. 5, 2025

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For and against tumor microenvironment: Nanoparticle-based strategies for active cancer therapy

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101626 - 101626

Published: March 1, 2025

Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive innovative perspective on how nanomedicine can modify TME to enhance therapy. Strategies include using nanoparticles improve oxygenation, adjust acidity, alter extracellular matrix, making treatments more effective. Additionally, immune responses activating cells reducing suppression within tumors. By integrating these approaches with existing therapies, such as chemotherapy radiotherapy, show promise in overcoming traditional barriers. The discusses changes effectiveness of itself, creating reciprocal relationship that boosts overall efficacy. We also highlight novel strategies aimed at exploiting TME, leveraging nanoparticle-based for targeted therapy through precise modulation.

Language: Английский

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Targeted apoptosis in breast cancer cells via niosome-mediated delivery of cyclophosphamide and sodium oxamate

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 18, 2025

Language: Английский

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Recent advances in biomimetic cell membrane–camouflaged nanoparticles for cancer therapy

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 116951 - 116951

Published: June 19, 2024

The emerging strategy of biomimetic nanoparticles (NPs) via cellular membrane camouflage holds great promise in cancer therapy. This scholarly review explores the utilization membranes derived from diverse entities; blood cells, immune stem and bacterial cells as examples NP coatings. camouflaging endows NPs with nuanced tumor-targeting abilities such self-recognition, homotypic targeting, long-lasting circulation, thus also improving tumor therapy efficacy overall. comprehensive examination encompasses a variety cell camouflaged (CMCNPs), elucidating their underlying targeted mechanisms delineating strategies for anti-cancer applications. Furthermore, systematically presents synthesis source materials methodologies employed order to construct characterize these CMCNPs, specific emphasis on use treatment.

Language: Английский

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Codelivery of methotrexate and silibinin by niosome nanoparticles for enhanced chemotherapy of CT26 colon cancer cells

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(5), P. 055015 - 055015

Published: July 2, 2024

Abstract Colon cancer (CC) is one of the most prevalent cancers in world, and chemotherapy widely applied to combat it. However, drugs have severe side effects emergence multi drug resistance (MDR) common. This bottleneck can be overcome by niosome nanocarriers that minimize dose/toxicity meanwhile allow co-loading incompatible for combination therapy. In this research, silibinin (Sil) as a hydrophobic was loaded into lipophilic part, methotrexate (MTX) hydrophilic part thin film hydration (TFH) method form Nio@MS NPs CT26 colon therapy vitro . Our results indicated synthesis ideal nanoparticles (NPs) with spherical morphology, size ∼100 nm, zeta potential −10 mV. The IC 50 value determined ∼2.6 µg ml −1 , which significantly lower than MTX-Sil (∼6.86 ), Sil (18.46 MTX (9.8 ). Further, reduced cell adhesion density, promoted apoptosis increased gene expression level caspase 3 BAX while significant downregulation BCL2. conclusion, design application co-administer increase cytotoxicity, reduce their dose improve anti-cancer combating MDR.

Language: Английский

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Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 564 - 586

Published: Dec. 5, 2024

Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science

Language: Английский

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GSH-Responsive Heterodimeric Dual-Targeted Nanomedicine Modulates EMT to Conquer Paclitaxel-Induced Invasive Breast Cancer Metastasis

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Paclitaxel (PTX), although effective against primary breast cancer, presents formidable clinical challenges due to severe toxicity and pro-metastatic potential, a critical concern as distant metastasis causes 90% of cancer-related deaths. To address these limitations, we designed prepared tumor microenvironment-responsive nanoprodrug, PTX-SS-3'HPT@RGD-HA NPs, that engineered RGD peptide-modified hyaluronic acid (HA) nanocarriers encapsulating the antimetastatic 3'-hydroxy pterostilbene (3'HPT) PTX heterodimer linked by glutathione (GSH)-cleavable disulfide bond. These nanoparticles targeting CD44 αvβ receptors overexpressed in aggressive cancer cells synergized enhanced permeability retention effects with receptor-mediated endocytosis, facilitating superior tumor-specific drug deposition GSH-activated payload release vitro vivo. Moreover, NPs achieved excellent growth inhibition while mitigating systemic metastatic risks 4T1 tumor-bearing mice. Mechanistically, 3'HPT counteracted PTX-induced epithelial-mesenchymal transition downregulating MMP-9/N-cadherin restoring E-cadherin expression, thereby neutralizing PTX-triggered effects. This study pioneers dual-targeted, toxicity-shielding nanoplatform simultaneously improves therapeutic efficacy addresses chemotherapy-driven metastasis, offering revolutionary strategy for managing highly invasive cancer.

Language: Английский

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αvβ3 integrin aptamer functionalized pH-responsive lipid polymer hybrid nanoparticles for targeted co-delivery of paclitaxel and tamoxifen

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141754 - 141754

Published: March 4, 2025

Language: Английский

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Integrating hyperthermia and chemotherapy: an intriguing approach based on Fe3O4 nanoparticles grafted with SN38 and MTX dual drugs for cancer theranostics

Journal of the Australian Ceramic Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Language: Английский

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Advances in acid-degradable and enzyme-cleavable linkers for drug delivery

Current Opinion in Chemical Biology, Journal Year: 2024, Volume and Issue: 84, P. 102552 - 102552

Published: Dec. 5, 2024

Language: Английский

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