Assay and Drug Development Technologies,
Journal Year:
2023,
Volume and Issue:
21(4), P. 157 - 165
Published: May 25, 2023
Candidosis
is
one
of
the
most
frequent
opportunistic
infections
and
exhibits
variable
clinical
presentations,
including
oral
localized
forms.
Drugs
affecting
renin-angiotensin
system
targets
inhibit
secreted
aspartic
proteases
from
Candida
albicans.
The
objective
study
was
to
evaluate
whether
losartan
has
antimicrobial
action
against
C.
albicans
biofilms.
Biofilms
were
treated
with
or
aliskiren
(for
comparison)
for
24
h.
Metabolic
activity
viable
cells
growth
inhibition
biofilms
assessed
using
XTT
[2,3-Bis(2-Methoxy-4-Nitro-5-Sulfophenyl)-5-[(Phenyl-Amino)Carbonyl]-2H-Tetrazolium
Hydroxide]
colony-forming
unit
assays,
respectively.
In
addition,
cytotoxicity
drugs
on
human
evaluated
AlamarBlue
assay.
Both
decreased
fungal
viability
at
all
concentrations.
concentrations
inhibited
biofilm,
ranging
47%
88.5%,
whereas
showed
1
10
mg/mL,
which
ranged
16%
97.6%.
Furthermore,
certain
concentrations,
these
maintained
cells.
Losartan
have
fungistatic
fungicidal
are
compatible
Therefore,
antihypertensive
can
be
repurposed
interfere
metabolism
development
biofilms,
widely
associated
forms
candidosis,
such
as
denture
stomatitis.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(10), P. 1410 - 1410
Published: Oct. 4, 2023
Metal
nanoparticles
(NPs)
have
garnered
considerable
attention,
due
to
their
unique
physicochemical
properties,
that
render
them
promising
candidates
for
various
applications
in
medicine
and
industry.
This
article
offers
a
comprehensive
overview
of
the
most
recent
advancements
manufacturing,
characterization,
biomedical
utilization
metal
NPs,
with
primary
focus
on
silver
gold
NPs.
Their
potential
as
effective
anticancer,
anti-inflammatory,
antimicrobial
agents,
drug
delivery
systems,
imaging
agents
diagnosis
treatment
variety
disorders
is
reviewed.
Moreover,
translation
therapeutic
settings,
issue
inclusion
clinical
trials,
are
assessed
light
over
30
investigations
concentrate
administering
either
or
NPs
conditions
ranging
from
nosocomial
infections
different
types
cancers.
paper
aims
not
only
examine
biocompatibility
nanomaterials
but
also
emphasize
challenges
may
limit
safe
integration
into
healthcare
practices.
More
than
100
nanomedicines
currently
market,
which
justifies
ongoing
study
use
medicine.
Overall,
present
review
highlight
innovative
therapeutics
field
biomedicine,
citing
some
relevant
current
applications.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(3), P. 273 - 273
Published: March 18, 2024
Oral
infections
occur
due
to
contact
between
biofilm
rich
in
Candida
albicans
formed
on
the
inner
surface
of
complete
dentures
and
mucosa.
This
study
investigated
historical
advances
prevention
treatment
oral
mucosal
infection
identified
gaps
literature.
Bibliographic
research
was
conducted,
looking
at
PubMed,
Embase,
Web
Science,
Scopus,
where
935
articles
were
found.
After
removing
duplicates
excluding
by
reading
title
abstract,
131
selected
for
full
104
included.
Another
38
added
from
gray
review
followed
PRISMA-ScR
guidelines.
The
period
described
ranges
1969
2023,
which,
during
21st
century,
vitro
vivo
studies
became
more
common
and,
2010
number
randomized
controlled
trials
increased.
Among
various
approaches
tested
are
incorporation
antimicrobial
products
into
prosthetic
materials,
improvement
denture
hygiene
protocols,
development
synthetic
natural
chemical
control
microorganisms,
intervention
with
local
or
systemic
agents.
Studies
report
good
results
brushing
combined
sodium
hypochlorite,
new
disinfectant
solutions
incorporated
materials
promising.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(3), P. 104 - 104
Published: March 14, 2025
This
comprehensive
review
of
dental
resin
adhesives
explores
their
historical
development,
key
components,
recent
innovations,
and
potential
future
directions,
highlighting
a
dynamic
continually
advancing
field.
From
Buonocore’s
breakthrough
acid-etching
technique
Bowen’s
pioneering
invention,
successive
generations
clinicians
scientists
have
pushed
forward
the
technological
materials
development
for
secure
bonding,
while
preserving
tissues.
The
discusses
substantial
advances
in
improving
adhesive
reliability,
enabling
more
conservative
treatment
approaches.
It
also
delves
into
enhancing
fundamental
components
synergistic
combinations.
Recent
including
biostable
functional
resins,
nanotechnology,
bioactive
address
persistent
challenges
such
as
durability,
antimicrobial
efficacy,
therapeutic
functionality.
Emerging
technologies,
digital
dentistry,
artificial
intelligence,
bioinspired
adhesives,
portend
an
exciting
promising
adhesives.
underscores
critical
role
ongoing
research
developing
biocompatible,
multifunctional,
durable
aims
to
support
professionals
researchers
by
providing
understanding
progression
inspiring
continued
innovation
excellence
restorative
dentistry.
Colloids and Interfaces,
Journal Year:
2023,
Volume and Issue:
7(4), P. 66 - 66
Published: Nov. 8, 2023
This
study
focuses
on
the
synthesis
of
silver
nanoparticles
(AgNPs)
at
different
high
concentrations
and
investigates
their
physicochemical
properties,
antimicrobial
activity,
cytotoxicity.
AgNPs
were
synthesized
using
alcohol
reduction
process,
involving
AgNO3
its
subsequent
stabilization
via
PVP
80
°C
for
4
h.
The
AgNO3/PVP
molar
ratio
average
molecular
weight
modified
in
this
study.
Characterization
analyses
revealed
that
exhibited
characteristic
surface
plasmon
resonance
absorption
peaks
approximately
415
nm,
as
observed
UV–Vis
spectrum.
results
presented
X-ray
diffractograms
confirmed
face-centered
cubic
structure
metallic
Ag
nanoparticles.
demonstrated
uniform
size
shape,
with
controllable
dimensions
ranging
from
3
to
800
nm.
Regarding
MIC
solutions
higher
potency
against
planktonic
cells
Candida
albicans.
determination
inhibition
halos
indicated
had
an
impact
microorganisms
Streptococcus
mutans,
albicans,
Actinomyces
israelii.
Furthermore,
lower-concentration
compositions
showed
reduced
cytotoxic
effects
compared
higher-concentration
particles.
Based
findings,
it
was
concluded
plays
a
crucial
role
production
AgNPs.
These
exhibit
desirable
properties
demonstrate
potential
activity
controlled
Future Microbiology,
Journal Year:
2024,
Volume and Issue:
19(8), P. 655 - 665
Published: May 3, 2024
Aim:
To
evaluate
the
biological
and
mechanical
properties
of
an
adhesive
with
nanostructured
silver
vanadate
(AgVO3).
Materials
&
methods:
Specimens
in
poly(methyl
methacrylate)
(PMMA)
were
treated
Ultra
Corega
Cream
(UCCA)
denture
or
without
AgVO3.
Biofilms
Candida
albicans,
glabrata
Streptococcus
mutans
grown
viable
cells
counted.
Fluorescence
microscopy
was
used.
The
viability
VERO
cell
strength
evaluated.
Results:
All
concentrations
AgVO3
reduced
biofilm
formation
showed
no
cytotoxic
effect.
At
5
min
24
h,
UCCA
10%
better
performance,
respectively.
Conclusion:
promoted
antibiofilm
activity
adhesive,
a
positive
effect
on
strength,
biocompatible.
Middle East Journal of Rehabilitation and Health Studies,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: Sept. 3, 2023
Background:
Denture
stomatitis
(DS)
is
a
chronic
mucosa
inflammation
that
supports
removable
dentures.
Candida
albicans
the
most
critical
factor
in
pathogenesis
of
DS.
Systemic
antifungal
drugs
such
as
nystatin
are
effective
people
with
acute
candidiasis.
Yet,
cases
predisposing
factors
denture,
cannot
completely
control
infection,
and
recurrences
common.
Objectives:
In
this
study,
resistance
sensitivity
oral
C.
species
to
were
evaluated,
effect
silver
nanoparticles
(AgNPs)
was
investigated
on
nystatin-resistant
specimens.
Methods:
This
vitro
study
performed
20
specimens
isolated
from
patients
denture
stomatitis.
After
confirmation
biofilm
preparation,
applied
biofilm.
The
results
recorded
minimum
growth
inhibitory
concentration
(MIC)
using
Clinical
&
Laboratory
Standards
Institute
(CLSI)
standard
protocol,
MIC
more
than
1
µg/mL
categorized
resistant.
Then,
biofilms
re-formed
for
exposed
AgNPs,
reported.
Results:
revealed
8
(40%)
represented
when
nystatin.
AgNPs
exposure
group
showed
significantly
higher
efficiency
(P
<
0.05).
can
reduce
6
(75%
all
resistant
specimens).
Conclusions:
Both
against
formed
surfaces.
However,
seem
case
species.
