Journal of Physics Conference Series,
Journal Year:
2024,
Volume and Issue:
2837(1), P. 012046 - 012046
Published: Oct. 1, 2024
Abstract
Bioflavonoid
myricetin-capped
silver-selenium
nanoparticles
(Myr-AgSeNPs)
are
biosynthesized
successfully
by
a
green
approach.
The
physicochemical
properties
of
the
Myr-AgSeNPs
were
characterized
using
SEM,
EDS,
and
FTIR
techniques.
appeared
as
combined
spherical
rod
in
form
with
average
size
100
to
600
nm
size.
EDS
micrograph
confirms
appearance
Se
Ag
carbon
oxygen
atoms,
which
suggests
that
particles
have
high
purity.
atoms
correspond
organic
molecules
(myricetin)
attached
on
surface
nanoparticles.
results
indicates
functional
groups
myricetin
AgSeNPs,
coated
anticandidal
activity
was
examined
based
zone
inhibition
(ZOI)
studies
agar
well-diffusion
method.
shows
against
tested
candidiasis-causing
Candida
albicans
is
almost
equal
standard
antibiotic
fluconazole.
Finally,
this
study
might
be
good
candidate
for
effective
treatment
C.
albicans.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(17), P. 7912 - 7912
Published: Sept. 5, 2024
Recent
decades
clearly
demonstrate
the
growing
use
of
nanomaterials
in
medical
practice,
and
their
effectiveness
is
systematically
confirmed
by
consequent
scientific
research.
An
example
dentistry
endodontic
treatment,
which,
due
to
its
specificity,
one
most
demanding
procedures,
fraught
with
numerous
challenges,
such
as
difficulties
reaching
tooth
roots
ineffective
cleaning
or
insufficient
sealing
root
canals,
which
may
lead
re-infection
damage
adjacent
structures.
The
has
a
positive
impact
on
solving
these
problems,
combination
biomaterials
nanometric
technology
makes
treatment
more
effective,
precise
comfortable
for
patients,
contributes
improving
quality
dental
care.
Currently,
high
biocompatibility
can
be
used
endodontics
components
irrigation
solutions,
rinsing
canals
drug
carriers
intracanal
use.
Nanomaterials
are
also
sealants
filling
canals.
However,
latest
research
shows
that
reducing
size
materials
“nano”
scale
significantly
affects
basic
physicochemical
properties,
leads
increased
reactivity
ability
interact
at
molecular
level.
These
unique
have
contributed
medical-related
raise
concerns
provoke
discussions
about
safety
direct
contact
tissues.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 21, 2025
Abstract
Calcium
titanate
nanoparticles
(CaTiO
3
NPs)
have
garnered
significant
attention
due
to
their
unique
properties
and
excellent
biocompatibility,
which
led
increased
use
in
various
fields
consumer
products.
This
rise
application
necessitates
a
better
understanding
of
biological
toxicological
effects.
However,
there
is
limited
data
on
the
cytotoxicity
genotoxicity
CaTiO
NPs
human
normal
skin
fibroblasts
(HSF)
non-small
lung
cancer
(A-549)
cells.
Consequently,
this
study
aimed
explore
effect
48-hour
exposure
cell
viability,
genomic
DNA
integrity,
oxidative
stress
induction
A-549
cells,
compared
HSF
The
were
assessed
using
Sulforhodamine
B
(SRB)
Alkaline
Comet
assays,
respectively.
To
estimate
possible
variation
apoptotic
gene
expression,
reactive
oxygen
species
(ROS)
analysis
quantitative
real-time
polymerase
chain
reaction
(qRT-PCR)
also
performed.
Our
findings
demonstrated
that
for
48
h
resulted
low
toxicity
toward
both
with
death
observed
only
at
high
concentrations
(100
1000
µg/ml).
IC50
value
cells
was
greater
than
µg/ml;
specifically,
1670.65
µg
/ml.
treatment
concentration
/ml
damage
excessive
ROS
generation,
along
notable
disturbance
expression
level
(p53
Bax)
anti-apoptotic
Bcl2
genes
In
contrast,
no
changes
treated
same
(1670.65
/ml)
NPs.
Collectively,
these
indicated
despite
short-term
causing
selectively
genotoxic
mediated
through
disrupted
integrity
altered
genes,
triggering
apoptosis
Further
vitro
vivo
studies
are
needed
fully
understand
