Cladonia rangiformis Acetone Extract— New Insight into the Chemical Composition and Biological Activity DOI Creative Commons
Ivana Dimitrijević, Violeta Mitić, Vesnа Stаnkov-Jovаnović

et al.

Natural Product Communications, Journal Year: 2023, Volume and Issue: 18(11)

Published: Nov. 1, 2023

Introduction Cladonia rangiformis, also known as reindeer lichen, has been used for various remedies in folk medicine. The rich nutritional value of this lichen is reflected the fact that it contains atranorin, which proven to have numerous biological activities. Objective chemical composition, antioxidant, anticholinesterase, and antigenotoxic activities C. rangiformis acetone extract were investigated. novelty work anticholinesterase activity, protective effect on human lymphocytes, antioxidant activity by cupric-reducing capacity (CUPRAC) method determined first time, well gas chromatography - mass spectrometry (GC-MS) profile. Methods Chemical composition was carried out high-performance liquid (HPLC)-diode array detector GC-MS. Antigenotoxic evaluated lymphocytes cytokinesis-block micronucleus assay. Total phenolic content, DPPH ABTS radical scavenging capacities, CUPRAC, total reducing power spectrophotometrically. Determination acetylcholinesterase performed Ellman's colorimetry statistical analysis variance (One-way ANOVA) using Origin software package version 7.0. Results HPLC identified 3 compounds with atranorin predominant constituent (97.2%). Fumarprotocetraric atraric acid represented a much smaller mutually approximate amount, 0.3 0.5%, respectively. Rangiformic most abundant volatile compound. Acetone (2 μg/mL) decreased frequency micronuclei 15.5% while radioprotectant amifostine reduced occurrence 11.4%. On contrary, at concentration 1.0 mg/mL exhibited an activating cholinesterase (2.0%), 10.0 showed weak inhibitory (7.3%). phenol content 132.71 μg gallic equivalents per mg dry extract. IC 50 experiment 16.19 11.80 mg/mL. Cupric 17.81 Trolox 0.45 ascorbic extract, Conclusion In addition previously time method, orcinol, β-orcinol, lauric alcohol, atranol, rangiformic GC-MS method. results proved had activity. Reduction number classified promising substances source beneficial effects DNA damage.

Language: Английский

Salazinic Acid and Norlobaridone from the Lichen Hypotrachyna cirrhata: Antioxidant Activity, α-Glucosidase Inhibitory and Molecular Docking Studies DOI Creative Commons

Tatapudi Kiran Kumar,

Bandi Siva,

Basani Kiranmai

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7840 - 7840

Published: Nov. 29, 2023

The present study was intended for the identification of secondary metabolites in acetone extract lichen Hypotrachyna cirrhata using UPLC-ESI-QToF-MS/MS and detection bioactive compounds. This led to 22 based on their MS/MS spectra, accurate molecular masses, formula from a comparison literature database (DNP), fragmentation patterns. In addition, potent antioxidant α-glucosidase inhibitory potentials H. motivated us isolate 10 metabolites, which were characterized as salazinic acid (11), norlobaridone (12), atranorin (13), lecanoric (14), lichesterinic (15), protolichesterinic (16), methyl hematommate (17), iso-rhizonic (18), atranol (19), methylatratate (20) spectral data. All these isolates assessed free radicals scavenging, radical-induced DNA damage, intestinal activities. results indicated that (19) showed activity, while depsidones (salazinic (12)) monophenolic compound (iso-rhizonic acid, (18)) displayed significant activities (p < 0.001), is comparable standard acarbose. These further correlated with docking studies, alkyl chain norlobaridione (12) hooked into finger-like cavity allosteric pocket; moreover, it also established Van der Waals interactions hydrophobic residues pocket. Thus, potency inhibit enzyme might be associated its binding. Also, MM-GBSA (Molecular Mechanics-Generalized Born Surface Area) binding energies (11) superior acarbose may have contributed high activity compared

Language: Английский

Citations

5
Hepatoprotective potentials of Usnea longissima Ach. and Xanthoparmelia somloensis (Gyelnik) Hale extracts in ethanol-induced liver injury DOI
Mehmet Berköz, Alı Aslan, Oruç Yunusoğlu

et al.

Drug and Chemical Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Sept. 25, 2024

In our study, the antioxidant and anti-inflammatory effects of different lichen applications were investigated in rats using an experimental ethanol toxicity model. 48 used study they divided into 6 groups with 8 each group. These were: control, (2 g/kg), +

Language: Английский

Citations

1
Lichens in Pharmacological Action: What Happened in the Last Decade? DOI Creative Commons
Yalçın Karagöz, Berna Öztürk

Eurasian Journal of Medicine, Journal Year: 2023, Volume and Issue: 54(Supp1), P. S195 - S208

Published: Jan. 18, 2023

Lichens are a unique group of organisms, which can produce compounds that named secondary metabolites and rarely or not produced in other organisms. possess pharmacological actions related to their metabolites. Our knowledge lichens rapidly increases as new technologies devices, facilitate the investigation chemical profile biological activities lichens, introduced become more readily available. In addition, methods perspectives, well suggestions for mechanisms, accumulate daily. Furthermore, lichen substances stand relatively untapped source natural products. Accordingly, researchers investigate lichen-derived material frequently than it was past. This review focused on published last 11 years (2012-2022). Literature data obtained from WebOfScience PubMed databases using search keywords revealed anti-genotoxicity, anticancer, anti-microbial activity studies have constantly been conducted. More recently, immunomodulatory inflammation-related took stage. Enzyme inhibition were popular well. selection based novelty mechanistic insight papers presented.

Language: Английский

Citations

3
Anti-yeast potential of lichen-extracted substances – An analytical review DOI

Łukasz Furmanek,

M. R. D. Seaward

South African Journal of Botany, Journal Year: 2023, Volume and Issue: 161, P. 720 - 779

Published: Sept. 7, 2023

Language: Английский

Citations

3
Lichens as a Natural Source of Compounds Active on Microorganisms of Human Health Interest DOI Creative Commons

Carla Condò,

Igor Anfelli,

Luca Forti

et al.

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(3), P. 1976 - 1976

Published: Feb. 3, 2023

The antimicrobial properties of two lichen extracts (LC1 and LC2 solutions extracted in acetone cyclohexane, respectively) were investigated against both Gram-positive Gram-negative microorganisms through the agar well diffusion assay. Results displayed that samples similarly effective all indicator strains. activity was maintained up to 30 days Candida albicans ATCC 10231 with an inhibition zone 38 mm 37 for LC1 extracted, respectively. In order separate single chemical components associate them biological activity, subjected activity-guided fractionation followed by a liquid chromatography mass spectrometry (LC–MS) Ion Trap 6310A characterization. Chromatogram analysis each sample revealed presence significant peak, at retention time (tR) 10.8 min, corresponding scabrosin derivative could likely be associated activity. obtained present investigation, especially opportunistic pathogen C. albicans, are encouraging represent preliminary step future solution toward microorganism responsible fungal infections, mainly occurring immunocompromised patients recently caused drug-resistant

Language: Английский

Citations

2
Solvent Effect on Total Phenolic Content, Total Flavonoids Content and the Antioxidant Activity of <i>Ramalina lacera</i> and <i>Evernia prunastri</i> Lichens Collected from the Trunks of <i>Argania spinosa</i> L. DOI Creative Commons
Amal Naama, Basma Aghoutane, Hanae El Monfalouti

et al.

Ecological Engineering & Environmental Technology, Journal Year: 2023, Volume and Issue: 24(9), P. 183 - 190

Published: Oct. 11, 2023

The study was aimed to evaluate the impact of extraction solvent on phenolic content, total flavonoids and antioxidant activities acetonic, methanolic, aqueous extracts two lichen species: Evernia prunastri Ramalina lacera collected from trunks Argania spinosa using ultrasound assistance extraction.Various in vitro assays were utilized such as 2,2-diphenly-picryly-hydroxyl free radical (DPPH) assay, ferric reducing power (FRAP) assay.All tested samples exhibited a good activity, for DPPH inhibition percentage ranged 85±0.2% 27±0.01%, content 13.17±0.5mgGAE/g DW 3.31±0.3mgGAW/g DW, 5.84±0.03mgRE/g 0.01±0.03mgRE/g DW.This demonstrates that has significant influence lichens compounds their also showed contents are significantly correlated activity studies lichens; moreover, it shows method extract compound.This suggests could be natural source.

Language: Английский

Citations

2
Evaluation of anticancer, immunomodulatory and anti-inflammatory potential of antioxidant rich Anzia ornatoides, a lichen species from eastern Himalayan region DOI
Pungbili Islary, Rajesh Kumar Meher, Suparna Biswas

et al.

South African Journal of Botany, Journal Year: 2023, Volume and Issue: 164, P. 266 - 279

Published: Dec. 7, 2023

Language: Английский

Citations

2
Chemical composition and antioxidant, enzyme inhibition and cytoprotective activity of two Antarctic lichens of the genus Psoroma (Pannariaceae) DOI
Alfredo Torres-Benítez,

José Erick Ortega-Valencia,

Mathias Hillmann-Eggers

et al.

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: May 30, 2024

Lichens contain different types of chemical compounds with multiple biological activities that demonstrate their potential pharmacological use. This research aims to report the metabolomic identification ethanolic extracts P. antarcticum and hypnorum, antioxidant, enzyme inhibitory, cytoprotection activity. Sixteen metabolites were identified in twelve hypnorum; reported variable antioxidant activity IC50 >350 µg/mL DPPH·, values >18 µmol Trolox/g ORAC >40 FRAP a phenolic compound content >10 mg GAE/g, as well significant results cholinesterases, α-glucosidase, pancreatic lipase, α-amylase, tyrosinase inhibition ranging from 18 510 µg/mL, which complemented by molecular docking experiments. Both showed improved at concentrations 0.5 1.0 μg/mL. study contributes knowledge diversity Antarctic lichen effectiveness evaluation related neurodegenerative diseases metabolic syndrome.

Language: Английский

Citations

0
Taxonomy of Lichen DOI
Darshita Sinha, Munmi Borkataky,

Bhaben Chowardhara

et al.

Published: June 7, 2024

Lichen taxonomy is a dynamic and ever-changing field that critical to understanding lichen variety, distribution, ecological relevance. This chapter presents comprehensive review of the current state taxonomy, highlighting challenges advancements in species identification, classification, nomenclature, molecular approaches. Various methodologies employed are discussed, including morphological examination, chemical analysis, techniques. Traditional approaches involving detailed examination thallus characteristics, reproductive structures, secondary metabolite production remain crucial for identification. Chemical analyses, such as thin-layer chromatography spot tests, provide valuable information on profiles aid delimitation. Furthermore, techniques, DNA barcoding, have revolutionized by providing insights into phylogenetic relationships genetic diversity lichens. The manuscript highlights recent integration multi-locus data application methods resolving complex taxonomic groups. These resulted discovery cryptic species, revisions, description new taxa. Additionally, discusses importance standardized nomenclature following International Code Nomenclature algae, fungi, plants (ICN). It emphasizes need collaboration among taxonomists open-access databases online resources disseminating information. In conclusion, this provides overview its importance, methodologies, advancements, challenges. serves resource researchers, taxonomists, conservationists working with lichens underscores role conserving diversity.

Language: Английский

Citations

0
Lichen as Pioneer of Natural Ecosystem DOI

Bhaskor Kolita,

Ridip Kumar Gogoi

Published: June 7, 2024

Language: Английский

Citations

0