Traditional Chinese medicine in lung cancer treatment

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 26, 2025

Lung cancer remains a major global health challenge and one of the leading causes cancer-related deaths worldwide. Despite significant advancements in treatment, challenges such as drug resistance, side effects, metastasis recurrence continue to impact patient outcomes quality life. In response, there is growing interest complementary integrative approaches care. Traditional Chinese medicine (TCM), with its long history, abundant clinical experience, holistic perspective individualized approach, has garnered increasing attention for role lung prevention management. This review provides comprehensive overview advances TCM covering theoretical foundation, treatment principles, experiences evidence supporting efficacy. We also provide systematic summary preclinical mechanisms, through which impacts cancer, including induction cell death, reversal inhibition modulation immune responses. Additionally, future prospects are discussed, offering insights into expanded application integration modern address this challenging disease.

Language: Английский

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MyD88 and Its Inhibitors in Cancer: Prospects and Challenges

Biomolecules, Journal Year: 2024, Volume and Issue: 14(5), P. 562 - 562

Published: May 7, 2024

The interplay between the immune system and cancer underscores central role of immunotherapy in treatment. In this context, innate plays a critical preventing tumor invasion. Myeloid differentiation factor 88 (MyD88) is crucial for immunity, activation MyD88 promotes production inflammatory cytokines induces infiltration, polarization, escape cells microenvironment. Additionally, abnormal signaling cell proliferation metastasis, which are closely associated with poor prognosis. Therefore, could serve as novel biomarker promising target therapy. Current strategies targeting including inhibition pathways protein multimerization, have made substantial progress, especially diseases chronic inflammation-induced cancers. However, specific regulating immunity tumorigenic mechanisms remains unclear. review describes involvement disease addition, classical non-classical inhibitors were collated to provide insights into potential treatment strategies. Despite several challenges complexities, avenue improving has revolutionize patient outcomes.

Language: Английский

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Herb pair of Huangqi‐Danggui exerts anti‐tumor immunity to breast cancer by upregulating PIK3R1

Animal Models and Experimental Medicine, Journal Year: 2024, Volume and Issue: 7(3), P. 234 - 258

Published: June 1, 2024

Abstract Background According to traditional Chinese medicine (TCM), drugs supplementing the vital energy, Qi, can eliminate tumors by restoring host immunity. The objective of this study is investigate underlying immune mechanisms anti‐tumor activity associated with Qi‐supplementing herbs, specifically paired use Huangqi and Danggui. Methods Analysis compatibility regularity was conducted screen combination TCMs. Using MTT assay a transplanted tumor mice model, effects TCMs were investigated in vitro vivo. High content analysis flow cytometry then used evaluate cellular immunity, followed network pharmacology molecular docking dissect significant active compounds potential mechanisms. Finally, mechanism ingredients verified experiments. Results There an optimal Danggui that, administered as aqueous extract, activate immunity suppress more effective than each drug on its own Based analysis, PIK3R1 core target for combined Molecular shows 6 components extract (quercetin, jaranol, isorhamnetin, kaempferol, calycosin, suchilactone) that bind PIK3R1. Jaranol most important component against breast cancer. suchilactone/jaranol and, especially, suchilactone/kaempferol are key enhancement extract. Conclusions cancer individual alone.

Language: Английский

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Study on the anti-skin aging effect and mechanism of Sijunzi Tang based on network pharmacology and experimental validation

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118421 - 118421

Published: June 15, 2024

Language: Английский

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Antiviral effects and mechanism of Qi pi pill against influenza viruses

Animal Models and Experimental Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Abstract Background Qi pi pill (QPP), which contains Renshen, Baizhu, Fuling, Gancao, Chenpi, Shanyao, Lianzi, Shanzha, Liushenqu, Maiya, and Zexie, was recommended for preventing treating COVID‐19 in Shandong Province (China). However, the mechanism by QPP treats infectious diseases remains unclear. This study aims to investigate therapeutic effect of vitro on acute influenza infection mice, exploring its action against A virus (IAV). Methods The activity assessed using dose–response curve analysis titer reduction assay, antiviral identified real‐time polymerase chain reaction (PCR), time‐of‐addition, enzymatic assays. efficacy further evaluated vivo BALB/c mice infected with IAV. At same time, each single Chinese herbal medicine preliminarily identify those effects. Results In results showed that exhibited a higher potency both B viruses, inhibiting viral RNA replication release targeting RNA‐dependent neuraminidase. Additionally, significantly decreased expression inflammatory cytokines A549 cells. revealed reduced lung index load tissue Lianzi were medicines from anti‐IAV activity. Conclusion targets IAV release, cytokine modulation host cells, provides protection infection.

Language: Английский

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Huqi formula suppresses hepatocellular carcinoma growth by modulating the PI3K/AKT/mTOR pathway and promoting T cell infiltration

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 19, 2025

Abstract Background Hepatocellular carcinoma (HCC) poses ongoing difficulties for public health systems due to its high incidence and poor prognosis. Huqi formula (HQF), a well-known prescription in traditional Chinese medicine, has demonstrated notable clinical effectiveness the treatment of HCC. However, mechanisms underlying therapeutic effects have yet be completely elucidated. Purpose This study aimed investigate anti-HCC HQF mechanisms. Methods Chemical profiling quantification were conducted by LC–MS HPLC. Orthotopic subcutaneous tumor models established through hydrodynamic injection Akt/Nras plasmids c-Met/sgPten cells, respectively, evaluate on Network pharmacology, RNA-Seq, molecular docking, Western blot, flow cytometry employed assess Results analysis identified 41 components, with HPLC showing salvianolic acid B as most abundant compound (0.303%). In c-Met/sgPten-induced HCC models, significantly reduced tissue damage, improved liver function, inhibited progression. Mechanistic studies revealed that induced apoptosis cells downregulating p-PI3K, p-AKT, p-mTOR expression, docking indicating strongest binding affinity between PI3K. further enhanced CD4 + CD8 T cell infiltration within microenvironment. When combined PD-1 therapy, efficacy against Finally, toxicity assays confirmed safety profile HQF. Conclusion significant synergistic effect PD-1, could used an alternative agent Graphical

Language: Английский

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Antitumor activity of gamma-irradiated Rosa canina L. against lung carcinoma in rat model: a proposed mechanism

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 28, 2025

Abstract Background Lung cancer is one of the most prevalent malignancies globally and leading cause cancer-related mortality. Although cisplatin a widely utilized chemotherapeutic agent, its clinical efficacy often hampered by significant toxicity undesirable side effects. Rosa canina, medicinal plant, has demonstrated range beneficial biological activities, including anti-inflammatory, anticancer, immunomodulatory, antioxidant, genoprotective Methods This study aimed to investigate potential canina enhance anticancer in dimethyl benz(a)anthracene-induced lung model using female rats. The animals were administered cisplatin, or combination both treatments. expression levels critical signaling molecules evaluated, phosphoinositide-3-kinase (PI3K), Akt, mammalian target rapamycin (mTOR), cleaved poly (ADP-ribose) polymerase (PARP-1), myeloid differentiation factor 88 (MyD88), tumor necrosis receptor-associated (TRAF), addition various autophagic markers. Furthermore, we assessed toll-like receptor 2 (TLR2), nuclear kappa B (NF-κB), apoptotic markers tissue, complemented histopathological examinations. Results combined treatment extract significantly inhibited cell proliferation downregulating PARP-1 TLR2/MyD88/TRAF6/NF-κB pathway, as well PI3K/Akt/mTOR pathway. Moreover, this therapy promoted autophagy apoptosis, evidenced elevated Conclusion Overall, findings suggest that enhances effects inhibiting while simultaneously inducing apoptosis. Thus, can be used adjuvant chemotherapy overcome limitations which may considered new approach during strategy. Graphical

Language: Английский

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Immunomodulatory effects of Lactobacillus salivarius on inflammatory pathways and cytokine expression in gastric adenocarcinoma cells

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102249 - 102249

Published: May 1, 2025

Language: Английский

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Traditional Chinese medicine combined with chemotherapy in the treatment of advanced non-small cell lung cancer: key drug screening and mechanism analysis

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 398(1), P. 843 - 854

Published: July 29, 2024

Language: Английский

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MiR-525-5p inhibits diffuse large B cell lymphoma progression via the Myd88/NF-κB signaling pathway

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e16388 - e16388

Published: Nov. 6, 2023

Diffuse large B-cell lymphoma (DLBCL) is a with high degree of aggressiveness. Recently, evidence has shown that miR-525-5p decreased in DLBCL, suggesting its possible involvement tumor progression. In this study, suppressed proliferation, invasion and clonogenicity, increased apoptosis U2932 cells, whereas silencing enhanced cell growth. Next, targets the 3'-UTR Myd88, Myd88 protein was tissues. Similar to mimic, siRNA invasion, cells. We observed reversed inhibitory effect on growth by transfecting cells mimics alone or together overexpression vector. addition, vivo studies have compared control group, upregulated expression reduced ability induce formation. conclusion, our results demonstrate inhibits progression DLBCL through Myd88/NF-κB pathway, which largely fills gap previous studies, may provide new reference for targeted treatment DLBCL.

Language: Английский

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