Analysis of Factors Affecting The Body Temperature of Postoperative Patients At RSUP Dr. M Djamil Padang DOI Creative Commons

Jefri Henky,

Enno Rhamadani Adma

Jurnal Health Sains, Journal Year: 2024, Volume and Issue: 5(2), P. 55 - 61

Published: Feb. 17, 2024

Introduction: Surgery is a medical procedure carried out using invasive methods by opening, cutting or slashing parts of the body to provide treatment patient. Changes in temperature can occur post-operative patients which are influenced age, gender, mass index (BMI), duration surgery, and type surgery. Objective: To analyze factors that influence at RSUP Dr. M. Djamil Padang. Methods: This study correlative analytical research cross sectional design. was conducted primary data samples were selected consecutive sampling technique with total 56 samples. Results: The results this show there relationship between age after surgery (p=0,021, r=-0,308), no gender (p=0,876, r=0,021), BMI (p=0,033, r=0,140), (p=0,027, r=-0,482), (p=0,762, r=0,041). Conclusion: There significant patient's

Language: Английский

Programmable Food-Derived Peptide Coassembly Strategies for Boosting Targeted Colitis Therapy by Enhancing Oral Bioavailability and Restoring Gut Microenvironment Homeostasis DOI
Meng Yang, Jingbo Liu, Chunmei Liu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Orally targeting nanostrategies of multiple nutraceuticals have attracted increasing attention in ulcerative colitis (UC) therapy for superior patient compliance, cost-effectiveness, and biocompatibility. However, the actual delivery bioefficacy are extremely restricted by their poor solubility, interior gastrointestinal retention, base permeability. Herein, we developed controllable colon-targeting nanoparticles (NPs) composed a quaternary ammonium chitosan (HTCC) shell succinic acid-modified γ-cyclodextrin (SACD) core precise UC treatment. Egg white-derived peptides (EWDP, typical food-derived peptides) could not only function as potential cross-linkers to induce differential coassembly with above biopolymers but also aid hydrophobic curcumin (Cur) solubility well nutrition enhancers oral synergism therapy. More specifically, NPs higher EWDP efficiency exhibited better pH-sensitive colloidal tunability (e.g., smaller size, rigidity, roughness) robust (EWDP/Cur) coloading capacity (24.0–33.2% ≫ 10%, pH 2.0–7.0). Compared pure nutraceuticals, excellent cellular absorption (almost 10 times) bioavailability (4.19–5.05 enhancement via faster mucus permeation macropinocytosis transport, indirectly regulating systemic inflammatory response. The sustainable sequential release targeted accumulation profiles directly facilitated interactions colonic microenvironment, verified intestinal barrier recovery gut microbiota restoration. Moreover, critical role amino acid metabolism reconfirmed importance maintaining homeostasis. Overall, this study would provide facile, quantitative, versatile perspective into programmable design peptide EWDP) coassembled nanoplatforms UC.

Language: Английский

Citations

5
Unveiling the Dark Side of Flavonoid: Rutin Provokes Hepatotoxicity in Low-Dose 2-Amino-3-methylimidazo [4,5-f] Quinoline-Exposed Mice via Regulating Gut Microbiota and Liver Metabolism DOI

Hongting Deng,

Yanan Zhao,

Yuanju He

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

2-Amino-3-methylimidazole [4,5-f] quinoline (IQ) is a kind of heterocyclic amine (HCAs) with high carcinogenicity in hot processed meat. Rutin (Ru) flavonoid compound anti-inflammatory and antioxidant properties. However, whether Ru scatheless under IQ-stimulated potential unhealthy conditions, especially liver function, vivo, unknown. In this study, we explored the effects underlying mechanism on injury induced by low dose IQ mice. Results showed that supplement led to upon low-dose alone administration, as shown histological analysis, inflammatory, serum biochemical indexes. Additionally, nontargeted metabolomics analysis revealed coexposure disrupted metabolic balance, leading significant changes metabolites pathways, hinting at possible relationship intestinal microbiota. Furthermore, 16S rRNA sequencing data indicated combination caused gut microbiota dysbiosis decreased level short-chain fatty acids (SCFAs). Correlation between microbiota, SCFAs, metabolites, damage markers highlighted crucial role gut-liver axis coexposure-induced vivo. general, study offers valuable perspective flavones HCA compounds realms food safety human health.

Language: Английский

Citations

1
Engeletin attenuates the inflammatory response via inhibiting TLR4-NFκB signaling pathway in Crohn's disease-like colitis DOI Creative Commons
Ziyun Wei, Xiao Ni,

He Cui

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118733 - 118733

Published: Aug. 23, 2024

Smilax glabra rhizome has a long history been used for clinical purposes in traditional Chinese medicinal treating various inflammatory conditions. Engeletin

Language: Английский

Citations

4
Enhanced precise therapy of ROS-sensitive dual-layer shell nanoparticles loading quercetin on DSS-induced ulcerative colitis mice DOI Creative Commons
Yang Bai, Danling Jiang, Boda Wu

et al.

APL Materials, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Ulcerative colitis (UC) is an intestinal condition, involving inflammatory response, apoptosis, and associated processes. As one of the traditional Chinese medicine treatments for UC, quercetin has received attention because it can attenuate inflammation. However, oral administration does not perform well in therapy. In this study, reactive oxygen species (ROS)-sensitive nanoparticles (Que@Gel-DA NPs) prepared by self-assembly polymerization were proposed treatment UC. Quercetin was encapsulated within a shell layer gelatin, followed dopamine on gelatin surface. Relative to free form quercetin, dual-layer encapsulation enhanced solubility bioavailability achieved intragastric protection, extended resident time gastrointestinal tract. Upon reaching colon lesion, underwent degradation response ROS, served enhance biocompatibility mitigate burst release. This resulted controlled release which enabled precise therapy exerted antibacterial anti-inflammatory effects. Furthermore, Que@Gel-DA NPs significantly alleviated UC symptoms dextran sodium sulfate (DSS)-induced mouse model. evidenced significant increase body weight, reduction occult blood feces, recovery crypt structure. The stained results indicated that inflammation promoting polarization M2 macrophages reduce apoptosis modulate immunity. Therefore, NPs, ROS-sensitive nano-drug delivery system, represent novel therapeutic approach clinical intervention

Language: Английский

Citations

0
Cucumaria frondosa intestines and ovum hydrolysates intervention ameliorates the symptoms of dextran sulfate sodium‐induced colitis by modulating gut microbiota and its metabolites DOI Open Access

Shunmin Gong,

Mingbo Li,

Jiarun Gao

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(3)

Published: March 1, 2025

Colitis, a troublesome inflammatory disease that significantly impacts daily life, has garnered considerable attention in recent times. Protolysates play crucial role the treatment of colitis, and intestines ovum Cucumaria frondosa represent readily available source these hydrolysates. However, effects C. hydrolysates (CFHs) on colitis have not been thoroughly investigated. We initially examined molecular weight distribution CFHs found fraction molecules with less than 1000 Da accounted for 86.98%, indicating hydrolysis primarily produced oligopeptides. Subsequently, we employed dextran sulfate sodium-induced experimental model to assess therapeutic potential CFHs. The findings indicated preventive administration dramatically attenuated pathological manifestations associated mice, including loss, colon shortening, tissue damage. Furthermore, suppressed secretion pro-inflammatory cytokines IL-6, TNF-α, IL-1β, as well MPO tissue. Metagenomic sequencing demonstrated could restore balance dysregulated gut microbiota by reinforcing Bacteroidota suppressing Verrucomicrobia populations, impacting various microbial functions. Metabolomic analyses further revealed exhibited more efficacious modulatory effect DSS-induced metabolic abnormalities, amino acid biosynthesis, linoleic metabolism, dopaminergic synapses. In conclusion, showed promise alleviating laying groundwork development application functional food relief.

Language: Английский

Citations

0
Baicalin-loaded peony seed polypeptide nanoparticles via a pH-driven method: Characterization, release kinetics, and in vitro anti-inflammatory effects DOI
Nan Chen, Hui Sun, Mu-xuan Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142958 - 142958

Published: April 1, 2025

Language: Английский

Citations

0
Brusatol ameliorates intestinal mucosal injury in ulcerative colitis via activating IL-22/STAT3 pathway DOI
Ying Xu, Li Chen, Xiaoxia Hu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114482 - 114482

Published: March 17, 2025

Language: Английский

Citations

0
Kiwifruit Polysaccharides Alleviate Ulcerative Colitis via Regulating Gut Microbiota-Dependent Tryptophan Metabolism and Promoting Colon Fucosylation DOI

Yixiao Li,

Yanhui Han, Xuejie Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(43), P. 23859 - 23874

Published: Oct. 21, 2024

A previous study showed that kiwifruit polysaccharide (KFP) has benefits in relieving intestinal inflammation, while the underlying mechanism remains unresolved. The objective of this was to investigate regulatory effect KFP on gut microbiota metabolism and barrier ulcerative colitis (UC) mice induced by dextran sulfate sodium (DSS). significantly improved UC symptoms including weight loss, shortened colon length, splenomegaly, diarrhea, hematochezia, inflammation mice. In addition, could alleviate DSS-caused dysbiosis increase levels short-chain fatty acids cecal contents Furthermore, results nontargeted targeted metabolomics analysis combined with antibiotic treatment revealed regulate microbiota-dependent tryptophan metabolism, activate aryl hydrocarbon receptor (AhR) cells, enhance interleukin-22 production tight junction proteins' (ZO-1, occludin, claudin3) expression repair Immunofluorescence upregulated conjunction lectin WGA UEA1 mouse colon, implying promoted fucosylation colon. These suggest alleviates primarily via targeting involved AhR pathway upregulating fucosylation.

Language: Английский

Citations

3
Shaoyao decoction alleviates DSS-induced colitis by inhibiting IL-17a-mediated polarization of M1 macrophages DOI Creative Commons
Shiying Wang,

Linkun Cai,

Yanyan Ma

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118941 - 118941

Published: Oct. 1, 2024

Language: Английский

Citations

1
Analysis of Factors Affecting The Body Temperature of Postoperative Patients At RSUP Dr. M Djamil Padang DOI Creative Commons

Jefri Henky,

Enno Rhamadani Adma

Jurnal Health Sains, Journal Year: 2024, Volume and Issue: 5(2), P. 55 - 61

Published: Feb. 17, 2024

Introduction: Surgery is a medical procedure carried out using invasive methods by opening, cutting or slashing parts of the body to provide treatment patient. Changes in temperature can occur post-operative patients which are influenced age, gender, mass index (BMI), duration surgery, and type surgery. Objective: To analyze factors that influence at RSUP Dr. M. Djamil Padang. Methods: This study correlative analytical research cross sectional design. was conducted primary data samples were selected consecutive sampling technique with total 56 samples. Results: The results this show there relationship between age after surgery (p=0,021, r=-0,308), no gender (p=0,876, r=0,021), BMI (p=0,033, r=0,140), (p=0,027, r=-0,482), (p=0,762, r=0,041). Conclusion: There significant patient's

Language: Английский

Citations

0