Polyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet DOI Creative Commons
Guoliang Wang,

Qiqi Han,

Xinpeng Yan

et al.

Journal of Functional Foods, Journal Year: 2021, Volume and Issue: 87, P. 104853 - 104853

Published: Nov. 10, 2021

This study is aims to evaluate the beneficial effects of polyphenols-rich extracts from walnut green husk (WGHP) on prevention obesity, nonalcoholic fatty liver disease (NAFLD), vascular endothelial dysfunction and colon tissue damage in rats fed high fat diet for 8 weeks. HPLC analysis showed that epicatechin, rutin caffeic acid are main components WGHP. Administration WGHP HF-fed effectively prevented abnormal body weight gain, lipid metabolism disorder, oxidative stress inflammation. Biochemical histopathological observation consistently confirmed protective NAFLD, caused by HF. In addition, 16S RNA sequencing results reduced Firmicutes/Bacteroidetes ratio reversed relative abundance Ruminococcaceae-UCG-014 Fusicatenibacter. These suggest may serve as a nutritional agent protecting liver, cardiovascular rats.

Language: Английский

Amelioration of Obesity‐Related Disorders in High‐Fat Diet‐Fed C57BL/6 Mice Following Fecal Microbiota Transplantation From DL‐Norvaline‐Dosed Mice DOI Open Access
Xin Li,

Bohan Sun,

Yanting Qin

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

ABSTRACT Fecal microbiota transplantation (FMT) could significantly alter the recipient's gut bacteria composition and attenuate obesity obesity‐related metabolic syndromes. DL‐norvaline is a nonproteinogenic amino acid possesses anti‐obesity potential. However, specific mechanisms by which might mediate beneficial effects of have not been completely elucidated. In this study, DL‐norvaline‐mediated FMT upregulated ( Clostridia_UCG_014 , Christensenellales Bacilli Ileibacterium Dubosiella Lactobacillus Muribaculaceae Bacteroidaceae ) downregulated harmful Tuzzerella Marinifilaceae ), further intestinal inflammation, oxidative stress, barrier were alleviated as well short chain fatty acids levels increased, thus alleviating glucose insulin metabolism, improving biochemical indexes energy metabolism decreasing body weight gain tissue weight. heat‐inactivated did demonstrate any those improvements in obese mice. Notably, both increased being signature alterations to marker caused DL‐norvaline. Therefore, transmissible via FMT. This study highlighted pivotal involvement development provided novel insight into underlying FMT, thereby potentially enhancing efficacy refinement utilization.

Language: Английский

Citations

2
Antrodin A fromAntrodia camphoratamodulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake DOI

Zhen-Wei Yi,

Xiaofeng Liu, Lihong Liang

et al.

Food & Function, Journal Year: 2021, Volume and Issue: 12(7), P. 2925 - 2937

Published: Jan. 1, 2021

In this study, we investigated the hepatoprotective effects of AdA and underlying mechanism at liver metabolomics gut microbiota levels under alcohol-induced injury conditions.

Language: Английский

Citations

76
Administration of Lactobacillus reuteri Combined with Clostridium butyricum Attenuates Cisplatin-Induced Renal Damage by Gut Microbiota Reconstitution, Increasing Butyric Acid Production, and Suppressing Renal Inflammation DOI Open Access
Yu‐Ping Hsiao, Hsiao‐Ling Chen, Jen‐Ning Tsai

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2792 - 2792

Published: Aug. 15, 2021

Cisplatin-induced nephrotoxicity is associated with gut microbiota disturbance. The present study aimed to investigate whether supplementation of Lactobacillus reuteri and Clostridium butyricum (LCs) had a protective effect on cisplatin-induced through reconstruction microbiota. Wistar rats were given different treatments: control, cisplatin (Cis), + C. L. (Cis+LCs), (LCs). We observed that cisplatin-treated supplemented LCs exhibited significantly decreased renal inflammation (KIM-1, F4/80, MPO), oxidative stress, fibrosis (collagen IV, fibronectin, a-SMA), apoptosis, concentration blood endotoxin indoxyl sulfate, increased fecal butyric acid production compared those without supplementation. In addition, improved the microbiome dysbiosis by maintaining healthy structure diversity; depleting Escherichia-Shigella Enterobacteriaceae family; enriching probiotic Bifidobacterium, Ruminococcaceae, Ruminiclostridium_9, Oscillibacter. Moreover, intervention alleviated intestinal epithelial barrier impairment. This indicated serves as mediator gut–kidney axis in restore composition, thereby suppressing uremic toxin enhancing butyrate production. Furthermore, renoprotective partially mediated increasing anti-inflammatory effects integrity barrier.

Language: Английский

Citations

70
Effects of Exopolysaccharides from Lactiplantibacillus plantarum JLAU103 on Intestinal Immune Response, Oxidative Stress, and Microbial Communities in Cyclophosphamide-Induced Immunosuppressed Mice DOI
Ji Wang, Meihe Li, Yawen Gao

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(7), P. 2197 - 2210

Published: Feb. 4, 2022

This study investigated the effects of exopolysaccharide from Lactiplantibacillus plantarum JLAU103 (EPS103) on intestinal immune response, oxidative stress, mucosal barrier, and microbial community in cyclophosphamide-induced immune-suppressed mice. The results showed that EPS103 promoted secretion cytokines generation secretory immunoglobulin A mucin-2 small intestine mice, which might be related to activation MAPK pathway. Additionally, protected against stress by activating antioxidation enzymes Nrf2/Keap1 pathways. It also improved physical barrier functions via regulating ratio villous height crypt depth upregulating expression tight-junction proteins. Meanwhile, short-chain fatty acids (SCFAs) modulated constituents gut microbiota. These suggested may modulate immunoresponse relying regulation SCFA production microbiota immunosuppressed resulting systemic immunity.

Language: Английский

Citations

39
Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice DOI Creative Commons
Bingyong Mao,

Weiling Guo,

Shumao Cui

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 13(2), P. 709 - 720

Published: April 14, 2023

Blautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and inflammation. This study aims to investigate the influences producta D4 on colitis induced by dextran sulfate sodium (DSS) reveal underlying mechanisms. Results showed that B. producta intervention significantly relieved body weight loss, suppressed elevation pro-inflammatory cytokines [including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β)] excessive oxidative stress [myeloperoxidease (MPO) activity, superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) malondialdehyde (MDA) level] mice. Moreover, concentrations tight junction proteins (occludin, claudin-1, ZO-1) related intestinal barrier were obviously elevated, colitis-related TLR4/NF-κB pathway activation was remarkably inhibited after intervention. The microbial disorder evidently ameliorated increasing relative abundance Clostridium sensu stricto 1, Bifidobacterium, GCA-900066225, Enterorhabdus, reducing Lachnospiraceae NK4A136 group. In conclusion, oral administration could ameliorate DSS-induced suppressing inflammatory responses, maintaining barrier, inhibiting TLR4/ NF-κB pathway, regulating microbiota balance. These results are conducive accelerate development as a functional probiotic for colitis.

Language: Английский

Citations

31
Gut microbiota: A magical multifunctional target regulated by medicine food homology species DOI Creative Commons

Wei‐Fang Zuo,

Qiwen Pang,

Lai-Ping Yao

et al.

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 52, P. 151 - 170

Published: June 2, 2023

The relationship between gut microbiota and human health has gradually been recognized. Increasing studies show that the disorder of is related to occurrence development many diseases. Metabolites produced by are responsible for their extensive regulatory roles. In addition, naturally derived medicine food homology species with low toxicity high efficiency have clearly defined owing outstanding physiological pharmacological properties in disease prevention treatment.Based on supporting evidence, current review summarizes representative work targeting regulate host pathophysiology discusses challenges prospects this field. It aims facilitate understanding among species, microbiota, further stimulate advancement more relevant research.As reveals, from initial practical application mechanism studies, evolved into an irrefutable interaction. On one hand, through affecting population structure, metabolism, function maintain homeostasis intestinal microenvironment microbiota. other also involved bioconversion active ingredients thus influences properties.

Language: Английский

Citations

28
The microbiome as a major function of the gastrointestinal tract and its implication in micronutrient metabolism and chronic diseases DOI Open Access
Dingbo Lin, Denis M. Medeiros

Nutrition Research, Journal Year: 2023, Volume and Issue: 112, P. 30 - 45

Published: March 4, 2023

Language: Английский

Citations

27
Modulating Effects of Turmeric Polysaccharides on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice DOI

Zongping Zhu,

Yirong Luo,

Li-Ting Lin

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(7), P. 3469 - 3482

Published: Feb. 8, 2024

Turmeric, a traditional medicinal herb, is commonly used as dietary and functional ingredient. This study aimed to investigate the effect of turmeric polysaccharides (TPs) on intestinal immunity gut microbiota in cyclophosphamide (Cy)-induced immunosuppressed BALB/c mice. We verified that oral administration TPs-0 TPs-3 (200 400 mg/kg, bw) improved thymus spleen indexes, increased whole blood immune cells (WBC) lymph count index, stimulated secretion serum immunoglobulin IgG. More importantly, could repair damage reduce inflammation. The specific mechanism ameliorating pathological damage, promoting CD4+ T cell secretion, regulating expression related cytokines, reducing level critical proteins NF-κB/iNOS pathway. Interestingly, intake significantly content short-chain fatty acids (SCFAs). Moreover, relieved disorder via proliferation abundance Lactobacillus Bacteroides inhibition Staphylococcus. Cumulatively, our suggests can relieve by repairing barrier flora disorders. TPs have potential applications for enhancing food.

Language: Английский

Citations

14
Polysaccharides of Floccularia luteovirens regulate intestinal immune response, and oxidative stress activity through MAPK/Nrf2/Keap1 signaling pathway in immunosuppressive mice DOI
He Ma, Abdul Mueed,

Daiyao Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134140 - 134140

Published: July 27, 2024

Language: Английский

Citations

9
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice DOI Creative Commons
Xingwei Xiang, Huizhen Zheng, Rui Wang

et al.

Marine Drugs, Journal Year: 2021, Volume and Issue: 19(8), P. 456 - 456

Published: Aug. 11, 2021

The intestinal flora is recognized as a significant contributor to the immune system. In this research, protective effects of oyster peptides on regulation and microbiota were investigated in mice treated with cyclophosphamide. results showed that restored indexes thymus, spleen liver, stimulated cytokines secretion promoted relative mRNA levels Th1/Th2 (IL-2, IFN-γ, IL-4 IL-10). Occludin, Claudin-1, ZO-1, Mucin-2 up-regulated, NF-κB signaling pathway was also activated after administration. Furthermore, treatment reduced proportion Firmicutes/Bacteroidetes, increased abundance Alistipes, Lactobacillus, Rikenell content short-chain fatty acids, reversed composition microflora similar normal mice. conclusion, effectively ameliorated cyclophosphamide-induced damage modified gut structure mice, might be utilized beneficial ingredient functional foods for regulation.

Language: Английский

Citations

52