Molecules,
Journal Year:
2022,
Volume and Issue:
27(21), P. 7398 - 7398
Published: Oct. 31, 2022
The
root
of
Millettia
speciosa
Champ.
(MSCP)
is
used
in
folk
medicine
and
popular
as
a
soup
ingredient.
composed
the
rhizome
radix,
but
only
radix
has
been
food.
Thus,
it
very
important
to
compare
chemical
components
antioxidant
activities
between
radix.
extracts
were
analyzed
by
UHPLC-Q-Exactive
Orbitrap-MS
multivariate
analysis,
evaluated
2,20-azinobis
(3-ethylbenzothiazo-line-6-sulfonic
acid)
diammonium
salt
(ABTS)
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
radical
scavenging
assays.
Ninety-one
compounds
detected
simultaneously
temporarily
identified.
Ten
identified
markers
distinguish
from
higher
than
rhizome.
Correlation
analysis
showed
that
uvaol-3-caffeate,
3-O-caffeoyloleanolic
acid,
khrinone
E
main
active
for
activity,
which
allowed
rapid
differentiation
rhizomes
Therefore,
could
be
helpful
future
exploration
its
material
base
bioactive
mechanism.
In
addition,
would
considered
new
method
quality
control
M.
speciosa.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: May 19, 2022
The
effects
of
Laminaria
japonica
fucoidan
(LF)
on
immune
regulation
and
intestinal
microflora
in
cyclophosphamide
(CTX)-treated
mice
were
investigated
this
work.
Results
indicated
that
LF
significantly
enhanced
the
spleen
thymus
indices,
promoted
lymphocyte
peritoneal
macrophages
proliferation,
increased
immune-related
cytokines
production
serum.
Moreover,
could
regulate
flora
composition,
increasing
abundance
Lactobacillaceae
Alistipes
,
inhibiting
Erysipelotrichia
Turicibacter
Romboutsia
Peptostreptococcaceae
Faecalibaculum
.
These
results
positively
correlated
with
characteristics.
Overall,
be
useful
as
a
new
potential
strategy
to
mitigate
CTX
immunosuppression
microbiota
disorders.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(7), P. 3469 - 3482
Published: Feb. 8, 2024
Turmeric,
a
traditional
medicinal
herb,
is
commonly
used
as
dietary
and
functional
ingredient.
This
study
aimed
to
investigate
the
effect
of
turmeric
polysaccharides
(TPs)
on
intestinal
immunity
gut
microbiota
in
cyclophosphamide
(Cy)-induced
immunosuppressed
BALB/c
mice.
We
verified
that
oral
administration
TPs-0
TPs-3
(200
400
mg/kg,
bw)
improved
thymus
spleen
indexes,
increased
whole
blood
immune
cells
(WBC)
lymph
count
index,
stimulated
secretion
serum
immunoglobulin
IgG.
More
importantly,
could
repair
damage
reduce
inflammation.
The
specific
mechanism
ameliorating
pathological
damage,
promoting
CD4+
T
cell
secretion,
regulating
expression
related
cytokines,
reducing
level
critical
proteins
NF-κB/iNOS
pathway.
Interestingly,
intake
significantly
content
short-chain
fatty
acids
(SCFAs).
Moreover,
relieved
disorder
via
proliferation
abundance
Lactobacillus
Bacteroides
inhibition
Staphylococcus.
Cumulatively,
our
suggests
can
relieve
by
repairing
barrier
flora
disorders.
TPs
have
potential
applications
for
enhancing
food.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 21, 2024
Polysaccharides
are
generally
considered
to
have
immune
enhancing
functions,
and
mulberry
leaf
polysaccharide
is
the
main
active
substance
in
leaves,
while
there
few
studies
on
whether
(MLP)
has
an
effect
immunosuppression
intestinal
damage
caused
by
cyclophosphamide
(CTX),
we
investigated
MLP
ameliorative
CTX.
A
total
of
210
1-day-old
Mahuang
cocks
were
selected
for
this
experiment.
Were
equally
divided
into
six
groups
used
evaluate
MLP.
Our
results
showed
that
significantly
enhanced
growth
performance
chicks
elevated
secretion
cytokines
(IL-1β,
IL-10,
IL-6,
TNF-α,
IFN-γ),
immunoglobulins
antioxidant
enzymes
serum
immunosuppressed
chicks.
It
attenuated
jejunal
expression
tight
junction
proteins
Claudin1,
Zo-1
MUC2,
which
protected
health.
activated
TLR4-MyD88-NF-κB
pathway
TLR4,
MyD88
NF-κB,
served
protect
intestine.
16S
rDNA
gene
high-throughput
sequencing
increased
species
richness,
restored
CTX-induced
gut
microbiome
imbalance,
abundance
probiotic
bacteria
gut.
improves
cyclophosphamide-induced
inhibition
modulating
flora
regulation
capacity.
In
conclusion,
study
provides
a
scientific
basis
as
enhancer
regulate
chick
mucosal
damage.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Oct. 28, 2022
Tetrastigma
hemsleyanum
Diels
et
Gilg
is
a
traditional
Chinese
herbal
medicine
with
high
medicinal
value,
and
antitumor,
antioxidant
anti-inflammatory
biological
activities.
However,
while
several
studies
have
focused
on
flavonoids
in
tubers,
there
are
few
the
enhanced
immune
effect
of
polysaccharides
(THP).
In
this
study,
we
evaluated
antitumor
THP
lung
tumor
model
explored
mechanism
activity
through
intestinal
flora.
addition,
cyclophosphamide
(CTX)-induced
immunosuppression
was
used
to
declare
immunomodulatory
immunosuppressive
state
induced
by
drugs.
The
results
showed
that
increased
content
ileum
secreted
immunoglobulin
A
(SIgA)
cecum
short-chain
fatty
acids
(SCFAs)
improved
microbial
community
diversity,
regulating
relative
abundance
dominant
microbiota
flora
from
phylum
level
genus
level,
recovering
microflora
disorder
caused
tumors.
Additionally,
can
increase
organ
indices
improve
atrophy.
upregulate
routine
blood
counts
stimulate
production
serum
cytokines.
also
promoted
macrophage
phagocytic
index,
NK-cell
activation,
complement
(IgG,
IgA,
IgM)
levels.
detection
Splenic
lymphocyte
proliferation
T
subsets
sideways
reflects
restore
CTX-induced
inhibition
mice.
conclusion,
study
suggests
effectively
achieve
effects,
regulate
gut
Therefore,
enhance
capacity
provide
novel
antineoplastic
adjuvant
agents.
Carbohydrate Polymer Technologies and Applications,
Journal Year:
2024,
Volume and Issue:
7, P. 100526 - 100526
Published: June 1, 2024
Functional
polysaccharides
are
characterized
by
functional
and
structural
biomolecules,
which
play
a
dual
role,
both
as
nutrient
molecules
providing
energy
signalling
involved
in
intercellular
communications.
There
increasing
evidences
showing
that
possess
beneficial
effects
for
treating
chronic
diseases,
such
cancer,
cardiovascular
disease,
etc,
but
its
mechanism
of
action
remains
imprecision.
Additionally,
due
to
the
limitations
precision
detection
methods
complexity
their
structures,
metabolic
kinetics
behaviours
or
bioavailability
polysaccharides,
interaction
between
it
entering
systemic
circulation
target
cells
have
been
conundrum
faced
researcher.
This
review
summarized
latest
advances
efficacy
diseases
structure-activity
relationship,
absorption
behaviours,
specific
cellular
receptors
so
understand
mechanisms
bioactivities.
is
expected
provide
new
insights
paves
way
application.
Frontiers in Veterinary Science,
Journal Year:
2024,
Volume and Issue:
11
Published: May 27, 2024
The
aim
of
this
experiment
was
to
investigate
the
modulation
effect
Acanthopanax
senticosus
polysaccharide
(ASPS-PD)
extracted
with
deep
eutectic
solvent
on
cyclophosphamide-induced
immunosuppression
in
broilers
and
its
gut
microbiota
broilers.
108
one-day-old
were
divided
into
six
groups,
including
control
group,
Cyclophosphamide
(CY)
model
ASPS-PD
ASPA-PD
high
low
dose
groups
Astragalus
group.
Body
weight,
feed
intake,
conversion
ratio,
immune
organ
index
at
7,
14,
21
days
determined;
IL-2,
IFN-γ,
lgG1
levels
determined
by
enzyme-linked
immunosorbent
assay
(ELISA);
Broiler
caeca
feces
analyzed
amplification
16S
rRNA
sequencing.
results
showed
that
can
restore
growth
performance,
increase
improve
serum
cytokine
IL-2
IFN-γ
immunoglobulin
CY-treated
analysis
cecum
flora
promote
proliferation
beneficial
bacteria
reduce
number
harmful
bacteria,
regulating
intestinal
flora.
Therefore,
may
be
a
potential
novel
immunomodulator
ameliorate
CY-induced
dysregulation
broiler.
